Mometasone furoate

产品说明书

Print
Chemical Structure| 83919-23-7 同义名 : 糠酸莫米松 ;Sch32088
CAS号 : 83919-23-7
货号 : A133834
分子式 : C27H30Cl2O6
纯度 : 98%
分子量 : 521.429
MDL号 : MFCD00866003
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(95.89 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Mometasone furoate is a glucocorticoid receptor agonist with anti-inflammatory and anti-allergic activity. Mometasone furoate acts as a corticosteroid agent and used for topical applications in chronic skin eczema and airway inflammation management of asthma in vivo. Mometasone furoate exhibits high potency with greater anti-inflammatory activity and a longer duration of action than betamethasone. The molecular biotransformation of mometasone furoate in the skin results in a lower affinity with dermal cells than epidermal cells, which contributes to its low atrophogenicity[3]. Breast cancer patients receiving MF (Mometasone Furoate) during PMRT (postmastectomy radiation) experienced significantly reduced rates of moist desquamation in comparison with a control cream[4].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.92mL

0.38mL

0.19mL

9.59mL

1.92mL

0.96mL

19.18mL

3.84mL

1.92mL
参考文献

[1]Magari M, Ikeda M, et al. Suppressive effects of mometasone furoate on an antigen-specific IgE antibody response and production of IL-4 in mice. Immunopharmacol Immunotoxicol. 2006;28(3):491-500.

[2]Tsumuro T, Ogawa M, et al. Effects of mometasone furoate on a rat allergic rhinitis model. Eur J Pharmacol. 2005 Nov 7;524(1-3):155-8.

[3]Spada F, Barnes TM, Greive KA. Comparative safety and efficacy of topical mometasone furoate with other topical corticosteroids. Australas J Dermatol. 2018 Aug;59(3):e168-e174

[4]Ho AY, Olm-Shipman M, Zhang Z, Siu CT, Wilgucki M, Phung A, Arnold BB, Porinchak M, Lacouture M, McCormick B, Powell SN, Gelblum DY. A Randomized Trial of Mometasone Furoate 0.1% to Reduce High-Grade Acute Radiation Dermatitis in Breast Cancer Patients Receiving Postmastectomy Radiation. Int J Radiat Oncol Biol Phys. 2018 Jun 1;101(2):325-333