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Mitapivat {[allProObj[0].p_purity_real_show]}

货号:A537823 同义名: AG-348 Ambeed 开学季,买赠积分,赢豪礼

PKR-IN-1 is a potent human R-type pyruvate kinase (PKR) inhibitor and also shows potency for mutant PKR including R510Q PKR, R532W PKR, T384W PKR etc.

Mitapivat 化学结构 CAS号:1260075-17-9
Mitapivat 化学结构
CAS号:1260075-17-9
Mitapivat 3D分子结构
CAS号:1260075-17-9
Mitapivat 化学结构 CAS号:1260075-17-9
Mitapivat 3D分子结构 CAS号:1260075-17-9
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Mitapivat 纯度/质量文件 产品仅供科研

货号:A537823 标准纯度: {[allProObj[0].p_purity_real_show]}
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Mitapivat 生物活性

描述 Mitapivat (AG-348) functions as an orally active allosteric activator of pyruvate kinase. It enhances enzymatic activity, protein stability, and ATP levels across various PKLR genotypes, indicating its potential in restoring the function of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat is applicable in the investigation of PK deficiency [1][2][3].
体内研究

Mitapivat (50 mg/kg; p.o.; twice daily for 21 days) ameliorates anemia in a mouse model of β-thalassemia [2].

体外研究

Mitapivat (0.1 nM-100 μM; 16 h) stimulates WT PK-R in red blood cells from healthy donors [1].

Mitapivat (0.01 nM-10 μM; 16 h) enhances ATP production in RBCs in a dose-dependent manner [1].

Mitapivat 参考文献

[1]Kung C, et al. AG-348 enhances pyruvate kinase activity in red blood cells from patients with pyruvate kinase deficiency. Blood. 2017 Sep 14;130(11):1347-1356.

[2]Matte A, et al. The pyruvate kinase activator mitapivat reduces hemolysis and improves anemia in a β-thalassemia mouse model. J Clin Invest. 2021 May 17;131(10):e144206.

[3]Rab MAE, et al. AG-348 (Mitapivat), an allosteric activator of red blood cell pyruvate kinase, increases enzymatic activity, protein stability, and ATP levels over a broad range of PKLR genotypes. Haematologica. 2021 Jan 1;106(1):238-249.

Mitapivat 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.22mL

0.44mL

0.22mL

11.10mL

2.22mL

1.11mL

22.19mL

4.44mL

2.22mL

Mitapivat 技术信息

CAS号1260075-17-9
分子式C24H26N4O3S
分子量 450.553
别名 AG-348
运输蓝冰
存储条件

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 20 mg/mL(44.39 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

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