生物活性 | |||
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描述 | Mitapivat (AG-348) functions as an orally active allosteric activator of pyruvate kinase. It enhances enzymatic activity, protein stability, and ATP levels across various PKLR genotypes, indicating its potential in restoring the function of PK (pyruvate kinase)-deficient glycolytic pathways. Mitapivat is applicable in the investigation of PK deficiency [1][2][3]. |
实验方案 | |||
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1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.22mL 0.44mL 0.22mL |
11.10mL 2.22mL 1.11mL |
22.19mL 4.44mL 2.22mL |
参考文献 |
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