产品说明书
Mirin
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同义名 : | - |
| CAS号 : | 1198097-97-0 | |
| 货号 : | A248394 | |
| 分子式 : | C10H8N2O2S | |
| 纯度 : | 98+% | |
| 分子量 : | 220.248 | |
| MDL号 : | MFCD05885480 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 30 mg/mL(136.21 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | (Z)-Mirin functions as an inhibitor targeting the MRN complex, comprising Mre11, Rad50, and Nbs1, thereby obstructing the MRN-mediated initiation of ATM activation without influencing the kinase activity of ATM itself. It effectively suppresses the exonuclease activity associated with Mre11. The compound enhances apoptosis, induces a G2/M cell cycle arrest, and significantly diminishes the efficiency of homology-directed repair (HDR)[1].[2]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.54mL 0.91mL 0.45mL |
22.70mL 4.54mL 2.27mL |
45.40mL 9.08mL 4.54mL |
| 参考文献 |
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