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盐酸米诺环素 /Minocycline HCl {[allProObj[0].p_purity_real_show]}

货号:A259020 同义名: 二甲胺四环素盐酸盐 / Minocycline HCl;CL 59806

Minocycline HCl是一种口服有效、能透过血脑屏障的半合成四环素类抗生素,亦为缺氧诱导因子 (HIF-1α) 抑制剂。同时,Minocycline hydrochloride 具有抗癌、抗炎和谷氨酸拮抗作用。

Minocycline HCl 化学结构 CAS号:13614-98-7
Minocycline HCl 化学结构
CAS号:13614-98-7
Minocycline HCl 3D分子结构
CAS号:13614-98-7
Minocycline HCl 化学结构 CAS号:13614-98-7
Minocycline HCl 3D分子结构 CAS号:13614-98-7
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Minocycline HCl 纯度/质量文件 产品仅供科研

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Minocycline HCl 生物活性

描述 Minocycline hydrochloride is a broad-spectrum tetracycline antibiotic. Minocycline hydrochloride on the GO-modified (graphene oxide) titanium surface (M@GO-Ti) showed a slow release behavior and exhibited excellent antibacterial activity with the synergistic effect of contact-killing and release-killing by GO and minocycline hydrochloride, respectively[3]. Minocycline hydrochloride is an effective sclerotizing agent. Percutaneous sclerosis with Minocycline hydrochloride is a very effective and promising nonsurgical treatment for patients with symptomatic simple cysts, and it can be performed without major complications[4]. MH-loaded (Minocycline Hydrochloride) in situ cubic liquid crystal possessed of sustained release ability and periodontal clinical symptoms improvement[5].

Minocycline HCl 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02946788 Acne Vulgaris Phase 2 Completed - United States, Florida ... 展开 >> Study Center Coral Gables, Florida, United States, 33146 United States, Nevada Study Center Las Vegas, Nevada, United States, 89128 收起 <<
NCT01173692 Oropharynx Cancer Phase 2 Active, not recruiting July 2019 United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 <<
NCT02355977 Chronic Periodontitis Phase 4 Completed - -

Minocycline HCl 参考文献

[1]Hu X, Wu B, et al. Minocycline attenuates ischemia-induced ventricular arrhythmias in rats. Eur J Pharmacol. 2011 Mar 11;654(3):274-9.

[2]Padi SS, Kulkarni SK. Minocycline prevents the development of neuropathic pain, but not acute pain: possible anti-inflammatory and antioxidant mechanisms. Eur J Pharmacol. 2008 Dec 28;601(1-3):79-87.

[3]Qian W , Qiu J , Su J , Liu X . Minocycline hydrochloride loaded on titanium by graphene oxide: an excellent antibacterial platform with the synergistic effect of contact-killing and release-killing. Biomater Sci. 2018 Jan 30;6(2):304-313. doi: 10.1039/c7bm00931c. PMID: 29184938.

[4]Danza FM, Falcione M, Bordonaro V, Infante A, Paladini A, Bonomo L. Minocycline hydrochloride as a soft sclerotizing agent for symptomatic simple renal and hepatic cysts. Eur Rev Med Pharmacol Sci. 2017 Jan;21(2):408-415. PMID: 28165544.

[5]Yang Z, Liang X, Jiang X, Guo J, Tao Y, Wang S, Cao Y, Gui S. Development and Evaluation of Minocycline Hydrochloride-Loaded In Situ Cubic Liquid Crystal for Intra-Periodontal Pocket Administration. Molecules. 2018 Sep 6;23(9):2275. doi: 10.3390/molecules23092275. PMID: 30200615; PMCID: PMC6225298.

Minocycline HCl 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.02mL

0.40mL

0.20mL

10.12mL

2.02mL

1.01mL

20.25mL

4.05mL

2.02mL

Minocycline HCl 技术信息

CAS号13614-98-7
分子式C23H28ClN3O7
分子量 493.94
别名 二甲胺四环素盐酸盐 ;Minocycline HCl;CL 59806
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 18 mg/mL(36.44 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 9 mg/mL(18.22 mM),配合低频超声助溶

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