产品说明书
Minocycline HCl
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同义名 : | 二甲胺四环素盐酸盐 ;Minocycline HCl;CL 59806 |
| CAS号 : | 13614-98-7 | |
| 货号 : | A259020 | |
| 分子式 : | C23H28ClN3O7 | |
| 纯度 : | 99% | |
| 分子量 : | 493.94 | |
| MDL号 : | MFCD00083669 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 18 mg/mL(36.44 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 9 mg/mL(18.22 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Minocycline hydrochloride is a broad-spectrum tetracycline antibiotic. Minocycline hydrochloride on the GO-modified (graphene oxide) titanium surface (M@GO-Ti) showed a slow release behavior and exhibited excellent antibacterial activity with the synergistic effect of contact-killing and release-killing by GO and minocycline hydrochloride, respectively[3]. Minocycline hydrochloride is an effective sclerotizing agent. Percutaneous sclerosis with Minocycline hydrochloride is a very effective and promising nonsurgical treatment for patients with symptomatic simple cysts, and it can be performed without major complications[4]. MH-loaded (Minocycline Hydrochloride) in situ cubic liquid crystal possessed of sustained release ability and periodontal clinical symptoms improvement[5]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02946788 | Acne Vulgaris | Phase 2 | Completed | - | United States, Florida ... 展开 >> Study Center Coral Gables, Florida, United States, 33146 United States, Nevada Study Center Las Vegas, Nevada, United States, 89128 收起 << |
| NCT01173692 | Oropharynx Cancer | Phase 2 | Active, not recruiting | July 2019 | United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Houston, Texas, United States, 77030 收起 << |
| NCT02355977 | Chronic Periodontitis | Phase 4 | Completed | - | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.02mL 0.40mL 0.20mL |
10.12mL 2.02mL 1.01mL |
20.25mL 4.05mL 2.02mL |
| 参考文献 |
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