亚甲蓝 /Methylene Blue {[allProObj[0].p_purity_real_show]}
货号：A151225同义名：
亚甲基蓝
/ Basic Blue 9;CI-52015
Methylene blue is a synthetic basic dye used in chromoendoscopy to identify dysplasia, or pre-cancerous lesions. It also can stain cells and tissues in research.It also works as a soluble guanylyl cyclase inhibitor.
Methylene blue (Basic Blue 9) inhibits guanylyl cyclase (sGC), monoamine oxidase A (MAO-A), and NO synthase (NOS). It acts as a vasopressor and is commonly used as a medical dye. Methylene blue impacts the nitric oxide synthase/guanylate cyclase signaling pathway to modulate prepulse inhibition and is a REDOX cycling compound that can cross the blood-brain barrier. Additionally, it inhibits Tau aggregation and is known to reduce cerebral edema, attenuate microglial activation, and lessen neuroinflammation[1][2][3].
体内研究
Methylene blue (Basic Blue 9), administered at 50 and 100 mg/kg intraperitoneally once for 25 minutes in male NMRI mice, reduces the absence of prepulse inhibition[1].
Methylene blue (Basic Blue 9) administered at doses of 20 and 40 mg/kg orally each day for six months to CaMKIIα-tTA transactivator mice helps preserve cognitive function in mice that express full-length pro-aggregant human Tau[2].
Methylene blue (Basic Blue 9), administered intravenously at a dose of 2 mg/kg for one day to TBI-treated male BALB/c mice, decreases the levels of inflammatory factors[3].
体外研究
Methylene blue (Basic Blue 9) at a concentration of 4.5 μM in BV2 microglia alters the immune profile of LPS-activated BV2 microglia, reducing levels of CD14, IL-1β, TNF-α, and CCL2 mRNA[3].
United States, Texas
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Research Imaging Institute, The University of Texas Health Science Center at San Antonio
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亚甲基蓝
;Basic Blue 9;CI-52015;Tetramethylthionine chloride;Methylthioninium chloride
运输
蓝冰
存储条件
液体-20°C:3-6个月-80°C:12个月
粉末Keep in dark place,Inert atmosphere,Room temperature
溶解度
H2O: 50 mg/mL(156.32 mM)，配合低频超声助溶
动物实验配方
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Methylene Blue | Basic Blue 9;CI-52015;Tetramethylthionine chloride;Methylthioninium chloride | 亚甲基蓝 | AmBeed-信号通路专用抑制剂
| Methylene Blue 纯度/质量文件
| Methylene Blue 生物活性
| Methylene Blue 临床数据
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| Methylene Blue 技术信息
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