产品说明书
Methylene Blue
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同义名 : | 亚甲基蓝 ;Basic Blue 9;CI-52015;Tetramethylthionine chloride;Methylthioninium chloride |
| CAS号 : | 61-73-4 | |
| 货号 : | A151225 | |
| 分子式 : | C16H18ClN3S | |
| 纯度 : | 98% | |
| 分子量 : | 319.85 | |
| MDL号 : | MFCD00012111 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Room temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
H2O: 50 mg/mL(156.32 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Methylene blue (Basic Blue 9) inhibits guanylyl cyclase (sGC), monoamine oxidase A (MAO-A), and NO synthase (NOS). It acts as a vasopressor and is commonly used as a medical dye. Methylene blue impacts the nitric oxide synthase/guanylate cyclase signaling pathway to modulate prepulse inhibition and is a REDOX cycling compound that can cross the blood-brain barrier. Additionally, it inhibits Tau aggregation and is known to reduce cerebral edema, attenuate microglial activation, and lessen neuroinflammation[1][2][3]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT02380573 | Mild Cognitive Impairment ... 展开 >> MCI Aging Alzheimer's Disease AD 收起 << | Phase 2 | Active, not recruiting | July 2019 | United States, Texas ... 展开 >> Research Imaging Institute, The University of Texas Health Science Center at San Antonio San Antonio, Texas, United States, 78229 收起 << |
| NCT02416531 | Vulvar Lichen Sclerosus | Not Applicable | Completed | - | Brazil ... 展开 >> Hospital Pérola Byington São Paulo, SP, Brazil, 01314000 收起 << |
| NCT02168452 | - | Completed | - | Korea, Republic of ... 展开 >> National Cancer Center Goyang-si, Gyeonggi-do, Korea, Republic of, 410-769 收起 << | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
3.13mL 0.63mL 0.31mL |
15.63mL 3.13mL 1.56mL |
31.26mL 6.25mL 3.13mL |
| 参考文献 |
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