Methoxsalen is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. Methoxsalen pretreatment prolonged the duration of nicotine-induced antinociception and hypothermia (15mg/kg, po) for periods up to 6- and 24-hr postnicotine administration, respectively[3]. Using the guinea pig as an experimental model, UV-A (long-wave UV) irradiation given immediately after the topical application of methoxsalen resulted in the notable suppression of tritiated thymidine incorporation into epidermal basal cells[4]. Oral methoxsalen when used in the higher dose followed by sun exposure is an effective treatment for psoriasis[5]. Administration of methoxsalen (50 mumol X kg-1 i.p.) increased 4-fold the hexobarbital sleeping time in rats. Methoxsalen (25-1000 microM) decreased cytochrome P-450 in vitro, in the presence of EDTA; this effect required NADPH and oxygen, was decreased by piperonyl butoxide and was increased by phenobarbital pretreatment. Similarly, administration of methoxsalen (125 mumol X kg-1 i.p.) decreased cytochrome P-450 and monooxygenase activities in vivo; the decrease in cytochrome P-450 was enhanced by phenobarbital pretreatment and was prevented by piperonyl butoxide[6].
Terminated(Closed early due to... 展开 >> poor accrual.) 收起 <<
-
United States, Illinois
... 展开 >>
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, United States, 60611-3013 收起 <<
United States, Arizona
... 展开 >>
Mayo Clinic Scottsdale
Scottsdale, Arizona, United States, 85259-5499
United States, Florida
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States, 32224
United States, Massachusetts
Tufts-NEMC Cancer Center
Boston, Massachusetts, United States, 02111
United States, Minnesota
Mayo Clinic Cancer Center
Rochester, Minnesota, United States, 55905
United States, Ohio
Jewish Hospital Cancer Center
Cincinnati, Ohio, United States, 45236
United States, Pennsylvania
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104-4283 收起 <<
Terminated(Closed early due to... 展开 >> poor accrual.) 收起 <<
-
United States, Illinois
... 展开 >>
Robert H. Lurie Comprehensive Cancer Center at Northwestern University
Chicago, Illinois, United States, 60611-3013 收起 <<
United States, Arizona
... 展开 >>
Mayo Clinic Scottsdale
Scottsdale, Arizona, United States, 85259-5499
United States, Florida
Mayo Clinic - Jacksonville
Jacksonville, Florida, United States, 32224
United States, Massachusetts
Tufts-NEMC Cancer Center
Boston, Massachusetts, United States, 02111
United States, Minnesota
Mayo Clinic Cancer Center
Rochester, Minnesota, United States, 55905
United States, Ohio
Jewish Hospital Cancer Center
Cincinnati, Ohio, United States, 45236
United States, Pennsylvania
Abramson Cancer Center of the University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104-4283 收起 <<
United States, Illinois
... 展开 >>
University of Illinois at Chicago
Chicago, Illinois, United States, 60612
United States, Missouri
Washington University Barnard Cancer Center
Saint Louis, Missouri, United States, 63110
United States, Texas
University of Texas - MD Anderson Cancer Center
Houston, Texas, United States, 77030-4009 收起 <<
United States, Connecticut
... 展开 >>
Yale Comprehensive Cancer Center at Yale University School of Medicine
New Haven, Connecticut, United States, 06520
United States, Massachusetts
Tufts-New England Medical Center
Boston, Massachusetts, United States, 02111
United States, Texas
Methodist Hospital - Texas Transplant Institute
San Antonio, Texas, United States, 78229 收起 <<
Prostate Cancer
... 展开 >> Rising Prostate Specific Antigen (PSA) 收起 <<
Phase 1
Phase 2
Recruiting
December 31, 2019
United States, New Jersey
... 展开 >>
AdvanceMed Research
Completed
Lawrence, New Jersey, United States, 08648
United States, New York
Montefiore Medical Center- Montefiore Medical Park
Not yet recruiting
Bronx, New York, United States, 10461
Contact: Gartrell Benjamin, MD 718-405-8404 bgartrel@montefiore.org
Eastchester Center for Cancer Care
Recruiting
Bronx, New York, United States, 10469
Contact: Carmen Vicuna 718-732-4078 cvicuna@nycancer.com
AccuMed Research Associates
Recruiting
Garden City, New York, United States, 11530-1664
Contact: Tammi Allegra, RN 516-746-2190 tallegra.accumedresearch@gmail.com
United States, Pennsylvania
MidLantic Urology
Recruiting
Bala-Cynwyd, Pennsylvania, United States, 19004
Contact: Cheryl A Zinar, RN, BSN 610-667-0458
Principal Investigator: Laurence H Belkoff, DO 收起 <<
United States, Alabama
... 展开 >>
University of Alabama at Birmingham Comprehensive Cancer Center
Birmingham, Alabama, United States, 35294-3300
United States, Arkansas
University of Arkansas for Medical Sciences
Little Rock, Arkansas, United States, 72205
United States, California
Stanford University Medical Center
Stanford, California, United States, 94305
United States, Colorado
University of Colorado Health Science Center
Aurora, Colorado, United States, 80010-0510
United States, Florida
H. Lee Moffitt Cancer Center and Research Institute
Tampa, Florida, United States, 33612-9497
United States, Illinois
Northwestern University Medical Center
Chicago, Illinois, United States, 60611
Rush-Presbyterian-St. Luke's Medical Center
Chicago, Illinois, United States, 60612
United States, Louisiana
Tulane University School of Medicine
New Orleans, Louisiana, United States, 70112
Slidell, Louisiana, United States, 70459-0059
United States, Massachusetts
Boston Medical Center
Boston, Massachusetts, United States, 02118-2393
United States, Michigan
Barbara Ann Karmanos Cancer Institute
Detroit, Michigan, United States, 48201-1379
Henry Ford Hospital
Detroit, Michigan, United States, 48202
United States, New York
StonyBrook Dermatology Associates, P.C.
East Setauket, New York, United States, 11733
St. Luke's-Roosevelt Hospital Center - Roosevelt Division
New York, New York, United States, 10019
United States, Ohio
Ireland Cancer Center
Cleveland, Ohio, United States, 44106-5065
United States, Tennessee
Knoxville Dermatology Group, P.C.
Knoxville, Tennessee, United States, 37920
United States, Texas
Simmons Cancer Center - Dallas
Dallas, Texas, United States, 75235-9154
University of Texas - MD Anderson Cancer Center
Houston, Texas, United States, 77030-4009
Tyler, Texas, United States, 75703 收起 <<
United States, Alabama
... 展开 >>
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35226
United States, California
University of California San Diego
La Jolla, California, United States, 92093
United States, Indiana
Indiana University Health
Indianapolis, Indiana, United States, 46202
United States, Iowa
University of Iowa
Iowa City, Iowa, United States, 52242
United States, Michigan
University of Michigan Health System
Ann Arbor, Michigan, United States, 48109
United States, Minnesota
University of Minnesota Medical Center, Fairview
Minneapolis, Minnesota, United States, 55455
United States, Missouri
Washington University School of Medicine
Saint Louis, Missouri, United States, 63110
United States, New York
Columbia University
New York, New York, United States, 10032
United States, Ohio
The Cleveland Clinic
Cleveland, Ohio, United States, 44195
United States, Pennsylvania
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213 收起 <<
Austria
... 展开 >> Medical University of Vienna; University Clinic of Dermatology; Division of Special and Environmental Dermatology
Vienna, Austria, 1090 收起 <<
France
... 展开 >> Centre de Santé - Etablissement Français du Sang (EFS)
Active, not recruiting
Lyon, France, 69003
Hôpital Edouard Herriot, Service d'Hématologie
Recruiting
Lyon, France, 69003
Contact: Aline Praire +33472117396 aline.praire@chu-lyon.fr
Principal Investigator: Mauricette Michallet, Professor 收起 <<
Austria
... 展开 >> Medical University of Graz
Graz, Austria, 8010
Department of Dermatology, Medical University of Innsbruck
Innsbruck, Austria, A-6020
Department of Dermatology, General Hospital of the City of Linz
Linz, Austria, A-4021
Department of Dermatology, Hospital Salzburg - Paracelsus Private Medical University
Salzburg, Austria, A-5020
Department of Dermatology, County Hospital St. Pölten
St. Pölten, Austria, A-3100
Department of Dermatology, Medical University of Vienna
Vienna, Austria, A-1090
Department of Dermatology, Hospital Hietzing
Vienna, Austria, A-1130
Department of Dermatology, Klinikum Wels
Wels, Austria, A-4600
Department of Dermatology, County Hospital Wiener Neustadt
Wiener Neustadt, Austria, A-2700 收起 <<
Austria
... 展开 >> Medical University of Vienna; University Clinic of Dermatology; Division of Special and Environmental Dermatology
Vienna, Austria, 1180 收起 <<
United States, Florida
... 展开 >>
University of Florida
Gainesville, Florida, United States, 32611
United States, Illinois
University of Chicago
Chicago, Illinois, United States, 60637
United States, Massachusetts
Tufts New England Medical Center
Boston, Massachusetts, United States, 02111
United States, Missouri
Kansas City Cancer Center
Kansas City, Missouri, United States, 64111
United States, Ohio
Cleveland Clinic Foundation
Cleveland, Ohio, United States, 44195
United States, Texas
Texas Transplant
San Antonio, Texas, United States, 78229
Australia
Royal Brisbane Hospital
Brisbane, Australia, 4006
Peter MacCallum Cancer Institute
East Melbourne, Australia, 8006
Alfred Hospital
Melbourne, Australia
Royal Melbourne Hospital
Parkville, Australia, 3050
St. Vincent's Hospital
Sydney, Australia, 2010
Brazil
Hospital Azevedo Carvalho
Jau, Brazil
National Cancer Institute
Rio de Janeiro, Brazil
Hemocentro
Sao Paulo, Brazil
Germany
Ludwig-Maximiliano Universitaet Muenchen
Munchen, Germany, D-81377
Italy
Careggi Hospital
Florence, Italy, 1-50134
San Martino Hospital
Genova, Italy, 16132
Portugal
Instituto Portugues de Oncologia de Francisco Gentil
Lisbon, Portugal, 1099-023
Slovakia
National Cancer Institute
Bratislava, Slovakia
Turkey
Ankara University Medical School
Ankara, Turkey, 6100
United Kingdom
Hammersmith Hospital
London, United Kingdom, W12 0NN 收起 <<
United States, Maryland
... 展开 >>
NIH
Bethesda, Maryland, United States
Metropolitian Gastroenterology Group
Chevy Chase, Maryland, United States
United States, New Jersey
Morristown Memorial Hospital
Morristown, New Jersey, United States
United States, New York
Mount Sinai Medical Center
New York, New York, United States
Austria
General Hospital of Vienna
Vienna, Austria
Belgium
Hospital Erasme/ULB
Brussels, Belgium
UZ Leuven
Leuven, Belgium
Germany
Universitat St Josef
Bochum, Germany
Krankenhaus Duren gem.GmbH
Duren, Germany
Universitatsklinik Essen
Essen, Germany
Universitatsklinikum
Jena, Germany
Universitatsklinikum Mannheim
Mannheim, Germany
University Hospital Munich-Grosshadem
Munich, Germany
Klinikum Oldenberg
Oldenburg, Germany
Medizinische Universitatsklinik Ulm
Ulm, Germany 收起 <<
United States, Illinois
... 展开 >>
Rush-Presbyterian Hospital
Chicago, Illinois, United States, 60612
United States, Massachusetts
Boston Medical Center
Boston, Massachusetts, United States, 02118
United States, Minnesota
University of Minnesota
Minneapolis, Minnesota, United States, 55455
United States, Ohio
University Hospital of Cleveland/Case Western Reserve University
Cleveland, Ohio, United States, 44106
United States, Pennsylvania
University of Pittsburgh
Pittsburgh, Pennsylvania, United States, 15213
United States, Tennessee
Vanderbilt University Medical Center
Nashville, Tennessee, United States, 37232
United States, Texas
MD Anderson Cancer Center
Houston, Texas, United States, 77030 收起 <<
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