产品说明书
Methoxsalen
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同义名 : | 甲氧沙林 ;8-Methoxypsoralen;Xanthotoxin;Oxsorale;Methoxypsoralen. US brand names: Ammoidin;NCI-C55903;8-MOP |
| CAS号 : | 298-81-7 | |
| 货号 : | A372661 | |
| 分子式 : | C12H8O4 | |
| 纯度 : | 98+% | |
| 分子量 : | 216.19 | |
| MDL号 : | MFCD00005009 | |
| 存储条件： |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(231.28 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Methoxsalen is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. Methoxsalen pretreatment prolonged the duration of nicotine-induced antinociception and hypothermia (15mg/kg, po) for periods up to 6- and 24-hr postnicotine administration, respectively[3]. Using the guinea pig as an experimental model, UV-A (long-wave UV) irradiation given immediately after the topical application of methoxsalen resulted in the notable suppression of tritiated thymidine incorporation into epidermal basal cells[4]. Oral methoxsalen when used in the higher dose followed by sun exposure is an effective treatment for psoriasis[5]. Administration of methoxsalen (50 mumol X kg-1 i.p.) increased 4-fold the hexobarbital sleeping time in rats. Methoxsalen (25-1000 microM) decreased cytochrome P-450 in vitro, in the presence of EDTA; this effect required NADPH and oxygen, was decreased by piperonyl butoxide and was increased by phenobarbital pretreatment. Similarly, administration of methoxsalen (125 mumol X kg-1 i.p.) decreased cytochrome P-450 and monooxygenase activities in vivo; the decrease in cytochrome P-450 was enhanced by phenobarbital pretreatment and was prevented by piperonyl butoxide[6]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00045305 | - | Completed | - | - | |
| NCT00724061 | Lymphoma | Not Applicable | Terminated(Closed early due to... 展开 >> poor accrual.) 收起 << | - | United States, Illinois ... 展开 >> Robert H. Lurie Comprehensive Cancer Center at Northwestern University Chicago, Illinois, United States, 60611-3013 收起 << |
| NCT00045305 | Leukemia Myel... 展开 >>odysplastic Syndromes Myelodysplastic/Myeloproliferative Neoplasms 收起 << | Phase 2 | Completed | - | United States, Arizona ... 展开 >> Mayo Clinic Scottsdale Scottsdale, Arizona, United States, 85259-5499 United States, Florida Mayo Clinic - Jacksonville Jacksonville, Florida, United States, 32224 United States, Massachusetts Tufts-NEMC Cancer Center Boston, Massachusetts, United States, 02111 United States, Minnesota Mayo Clinic Cancer Center Rochester, Minnesota, United States, 55905 United States, Ohio Jewish Hospital Cancer Center Cincinnati, Ohio, United States, 45236 United States, Pennsylvania Abramson Cancer Center of the University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104-4283 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
4.63mL 0.93mL 0.46mL |
23.13mL 4.63mL 2.31mL |
46.26mL 9.25mL 4.63mL |
| 参考文献 |
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