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甲巯咪唑 /Methimazole {[allProObj[0].p_purity_real_show]}

货号:A119279 同义名: 2-巯基-1-甲基咪唑 / Thiamazole;NSC 38608

Methimazole is an antithyroid medicine.

Methimazole 化学结构 CAS号:60-56-0
Methimazole 化学结构
CAS号:60-56-0
Methimazole 3D分子结构
CAS号:60-56-0
Methimazole 化学结构 CAS号:60-56-0
Methimazole 3D分子结构 CAS号:60-56-0
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Methimazole 纯度/质量文件 产品仅供科研

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Methimazole 生物活性

描述 Methimazole is a well-known antithyroid agent utilized primarily for the treatment and study of hyperthyroidism. Alongside its therapeutic use, methimazole is recognized for its significant hepatotoxicity, which is a major concern during its clinical application[1].[2].
体外研究

Furthermore, methimazole has been found to inhibit the secretion of CXC chemokine ligand 10 in human thyrocytes, highlighting its impact on immune modulation in thyroid cells[3].

Methimazole 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00677469 Graves Disease Not Applicable Completed - Iran, Islamic Republic of ... 展开 >> Endocrine and Metabolism Research Center Shiraz, Fars, Iran, Islamic Republic of 收起 <<
NCT01977963 - Recruiting - Taiwan ... 展开 >> National Taiwan University Hospital Recruiting Taipei, Taiwan Contact: Shyang-Rong Shih, PhD    886-972653337    srshih@ntu.edu.tw    Principal Investigator: Shyang-Rong Shih, PhD 收起 <<
NCT00725946 Breast Cancer ... 展开 >> Breast Cancer Early Stage Breast Cancer (Stage 1-3) Breast Cancer Metastatic Breast Cancer 收起 << Early Phase 1 Terminated - United States, California ... 展开 >> Stanford University School of Medicine Stanford, California, United States, 94305 收起 <<

Methimazole 参考文献

[1]Tatara MR, et al. Effects of long-term oral administration of methimazole on femur and tibia properties in male Wistar rats. Biomed Pharmacother. 2017 Oct;94:124-128.

[2]Reza Heidari, et al. Mechanisms of methimazole cytotoxicity in isolated rat hepatocytes. Drug Chem Toxicol. 2013 Oct;36(4):403-11.

[3]Crescioli C, et al. Methimazole inhibits CXC chemokine ligand 10 secretion in human thyrocytes. J Endocrinol. 2007 Oct;195(1):145-55.

Methimazole 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

8.76mL

1.75mL

0.88mL

43.79mL

8.76mL

4.38mL

87.59mL

17.52mL

8.76mL

Methimazole 技术信息

CAS号60-56-0
分子式C4H6N2S
分子量 114.169
别名 2-巯基-1-甲基咪唑 ;Thiamazole;NSC 38608;Northyx;Favistan
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Inert atmosphere,Room Temperature

溶解度

DMSO: 105 mg/mL(919.69 mM),注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(437.95 mM)

动物实验配方

PO 0.5% CMC-Na 40 mg/mL clear

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