产品说明书
Methimazole
 |
同义名 : | 2-巯基-1-甲基咪唑 ;Thiamazole;NSC 38608;Northyx;Favistan |
| CAS号 : | 60-56-0 | |
| 货号 : | A119279 | |
| 分子式 : | C4H6N2S | |
| 纯度 : | 99% | |
| 分子量 : | 114.169 | |
| MDL号 : | MFCD00179321 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(919.69 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(437.95 mM) |
|
| 动物实验配方： |
PO 0.5% CMC-Na 40 mg/mL clear |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Methimazole is a well-known antithyroid agent utilized primarily for the treatment and study of hyperthyroidism. Alongside its therapeutic use, methimazole is recognized for its significant hepatotoxicity, which is a major concern during its clinical application[1].[2]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT00677469 | Graves Disease | Not Applicable | Completed | - | Iran, Islamic Republic of ... 展开 >> Endocrine and Metabolism Research Center Shiraz, Fars, Iran, Islamic Republic of 收起 << |
| NCT01977963 | - | Recruiting | - | Taiwan ... 展开 >> National Taiwan University Hospital Recruiting Taipei, Taiwan Contact: Shyang-Rong Shih, PhD 886-972653337 srshih@ntu.edu.tw Principal Investigator: Shyang-Rong Shih, PhD 收起 << | |
| NCT00725946 | Breast Cancer ... 展开 >> Breast Cancer Early Stage Breast Cancer (Stage 1-3) Breast Cancer Metastatic Breast Cancer 收起 << | Early Phase 1 | Terminated | - | United States, California ... 展开 >> Stanford University School of Medicine Stanford, California, United States, 94305 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
8.76mL 1.75mL 0.88mL |
43.79mL 8.76mL 4.38mL |
87.59mL 17.52mL 8.76mL |
| 参考文献 |
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