醋酸甲地孕酮 /Megestrol acetate
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货号：A561132
同义名：
宜利治
/ Megestryl Acetate;BDH1298
Megestryl Acetate is a synthetic progesterone analog.
Megestrol acetate 化学结构
Megestrol acetate 3D分子结构
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Megestrol acetate 纯度/质量文件 产品仅供科研
货号：A561132
标准纯度：
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Megestrol acetate 质控信息
Cyproterone acetate
++++
Androgen Receptor, IC50: 7.1 nM
98%
Apalutamide
+++
Androgen Receptor, IC50: 16 nM
98%
AZD3514
+
Androgen Receptor, Ki: 2.2 μM
98%
Darolutamide
++++
Androgen receptor, Ki: 11 nM
98%
Flutamide
+++
Androgen Receptor, Ki: 55 nM
98%
Galeterone
++
Androgen Receptor, IC50: 384 nM
98%
Enzalutamide
+++
Androgen Receptor, IC50: 36 nM
98%
Megestrol
✔
98%
Bicalutamide
++
Androgen Receptor, IC50: 0.16 μM
99%
EPI-001
+
Androgen Receptor, IC50: ~6 μM
98%
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
Megestrol acetate 生物活性
描述
Megestrol acetate was one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer. As single-agent therapy, the average overall response rate to megestrol acetate therapy is 30%[3] [4] [5] [6]
Megestrol acetate 参考文献
[1] Sung JH, An HS, et al. Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor. Stem Cells Transl Med. 2015 Jul;4(7):789-99.
[2] Kelicen Ugur P, Lule S, et al. Megestrol acetate inhibits the expression of cytoplasmic aromatase through nuclear C/EBPβ in reperfusion injury-induced ischemic rat hippocampus. Eur J Pharmacol. 2011 Mar 11;654(3):217-25.
[3] Sedlacek SM. An overview of megestrol acetate for the treatment of advanced breast cancer. Semin Oncol. 1988 Apr;15(2 Suppl 1):3-13.
[4] Ruiz-García V, Juan O, Pérez Hoyos S, Peiró R, Ramón N, Rosero MA, García MA. Acetato de megestrol: una revisión sistemática de su utilidad clínica para la ganancia de peso en los enfermos con neoplasia y caquexia [Megestrol acetate: a systematic review usefulness about the weight gain in neoplastic patients with cachexia]. Med Clin (Barc). 2002 Jul 6;119(5):166-70. Spanish
[5] Femia RA, Goyette RE. The science of megestrol acetate delivery: potential to improve outcomes in cachexia. BioDrugs. 2005;19(3):179-87
[6] Caparrós GC, Zambrana JL, Delgado-Fernandez M, Díez F. Megestrol-induced Cushing syndrome. Ann Pharmacother. 2001 Oct;35(10):1208-10
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Megestrol acetate 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.60mL
0.52mL
0.26mL
13.00mL
2.60mL
1.30mL
26.01mL
5.20mL
2.60mL
Megestrol acetate 技术信息
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