Enzalutamide | MDV3100 | Androgen Receptor | AmBeed-信号通路专用抑制剂

规格	价格	会员价	库存	数量
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产品名称	Androgen Receptor ↓ ↑	纯度
Cyproterone acetate	++++ Androgen Receptor, IC50: 7.1 nM	98%
Apalutamide	+++ Androgen Receptor, IC50: 16 nM	98%
AZD3514	+ Androgen Receptor, Ki: 2.2 μM	98%
Darolutamide	++++ Androgen receptor, Ki: 11 nM	98%
Flutamide	+++ Androgen Receptor, Ki: 55 nM	98%
Galeterone	++ Androgen Receptor, IC50: 384 nM	98%
Enzalutamide	+++ Androgen Receptor, IC50: 36 nM	98%
Megestrol	✔	98%
Bicalutamide	++ Androgen Receptor, IC50: 0.16 μM	99%
EPI-001	+ Androgen Receptor, IC50: ~6 μM	98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

细胞系	浓度	检测类型	检测时间	活动说明	数据源
BCK4	10 μM	Function Assay	7 days	Inhibits estradiol-mediated proliferation	24451109
CWR22Rv1	15 μM	Function Assay	24 h	Does not affect the full length AR expression	23713567
human LNCAP		Cytotoxic Assay	7 days	IC50=5.12 μM	23713567
human LNCAP	1 μM	Function Assay		Inhibits prostate specific antigen secretion in human LNCAP cells expressing androgen receptor at 100-1000nM	20218717

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT01650194	Metastatic Castration-Resistan... 展开 >>t Prostate Cancer 收起 <<	Phase 2	Completed	-	United States, Texas ... 展开 >> Site US2492 MD Anderson Cancer Ctr Houston, Texas, United States, 77030 收起 <<
NCT03478904	Prostate Cancer	Phase 1	Recruiting	April 30, 2019	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office 888-624-1937 收起 <<
NCT03305224	Castration-resistant Prostate ... 展开 >>Cancer Bone Metastases 收起 <<	Phase 2	Recruiting	December 2019	Japan ... 展开 >> Osaka City University Graduate School of Medicine Recruiting Osaka, Japan, 545-8585 Contact: Taro Iguchi, MD, PhD 收起 <<
NCT02286921	Castration Resistant Metastati... 展开 >>c Prostate Cancer 收起 <<	Phase 2	Active, not recruiting	December 2019	United States, District of Col... 展开 >>umbia Sibley Memorial Hospital Washington, District of Columbia, United States, 20016 United States, Maryland SKCCC at Johns Hopkins Baltimore, Maryland, United States, 21205 收起 <<
NCT02300610	Bladder Cancer ... 展开 >> Carcinoma, Transitional Cell Renal Pelvis Cancer Ureter Cancer Urethra Cancer 收起 <<	Phase 1	Active, not recruiting	August 2019	United States, Florida ... 展开 >> H. Lee Moffitt Cancer Center and Research Institute Tampa, Florida, United States, 33612 United States, Minnesota University of Minnesota, Masonic Cancer Center Minneapolis, Minnesota, United States, 55455 收起 <<
NCT03531827	Metastatic Castration Resistan... 展开 >>t Prostate Cancer Prostate Neoplasms 收起 <<	Phase 2	Recruiting	June 30, 2020	United States, Maryland ... 展开 >> National Institutes of Health Clinical Center Recruiting Bethesda, Maryland, United States, 20892 Contact: For more information at the NIH Clinical Center contact National Cancer Institute Referral Office 888-624-1937 收起 <<
NCT01911715	Healthy Subjects ... 展开 >> Pharmacokinetics of MDV3100 收起 <<	Phase 1	Completed	-	Netherlands ... 展开 >> PRA International Zuidlaren, Netherlands, 9471GP 收起 <<
NCT01565928	Prostate Cancer	Phase 1	Completed	-	United States, New York ... 展开 >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Memorial Sloan-Kettering Cancer Center New York, New York, United States, 10065 United States, Virginia Virginia Oncology Associates Norfolk, Virginia, United States, 23502 收起 <<
NCT03246347	Prostate Cancer ... 展开 >> Prostate Adenocarcinoma 收起 <<	Phase 2	Recruiting	August 2020	United States, North Carolina ... 展开 >> Levine Cancer Institute Recruiting Charlotte, North Carolina, United States, 28204 Contact: Sandra Samu-Arce, RN 980-993-5484 sandra.samuarce@atriumhealth.org 收起 <<
NCT02254785	Metastatic Castration-Resistan... 展开 >>t Prostatic Cancer 收起 <<	Phase 2	Active, not recruiting	May 2020	Australia, Victoria ... 展开 >> Box Hill Hospital Box Hill, Victoria, Australia, 3128 Monash Health-Monash Medical Centre Clayton, Victoria, Australia, 3168 Peter MacCallum Cancer Centre Melbourne, Victoria, Australia, 3000 Canada, Alberta Tom Baker Cancer Cantre Calgary, Alberta, Canada, T2N 4N2 Cross Cancer Institute Edmonton, Alberta, Canada, T6G 1Z2 Canada, British Columbia BCCA - Kelowna Kelowna, British Columbia, Canada, V1Y 5J3 BCCA- Vancouver Center Vancouver, British Columbia, Canada, V5Z 4E6 Canada, Manitoba CancerCare Manitoba Winnipeg, Manitoba, Canada, R3E 0V9 Canada, Nova Scotia QEII Health Sciences Centre Halifax, Nova Scotia, Canada, B3H 1V7 Canada, Ontario Juravinski Cancer Centre Hamilton, Ontario, Canada, L8V 5C2 Durham Regional Cancer Centre (Lakeridge Health) Oshawa, Ontario, Canada, L1G 2B9 The Ottawa Hospital Cancer Centre Ottawa, Ontario, Canada, K1H 8L6 Princess Margaret Cancer Centre Toronto, Ontario, Canada, M5G 2M9 Canada, Quebec Jewish General Hospital Montreal, Quebec, Canada, H3T 1E2 Canada, Saskatchewan Saskatoon Cancer Center Saskatoon, Saskatchewan, Canada, 27N 4H4 收起 <<
NCT03314324	Metastatic Castrate-resistant ... 展开 >>Prostate (CRPC) Cancer 收起 <<	Phase 2	Recruiting	January 2022	France ... 展开 >> Gustave Roussy Recruiting Villejuif, Val De Marne, France, 94805 Contact: Karim FIZAZI, MD 0142114317 ext +33 karim.fizazi@gustaveroussy.fr Contact: Geraldine MARTINEAU, MD 0142115607 ext +33 geraldine.martineau@gustaveroussy.fr Principal Investigator: Karim FIZAZI, MD 收起 <<
NCT03344211	Castration-Resistant Prostate ... 展开 >>Carcinoma Prostate Carcinoma Metastatic in the Bone Stage IV Prostate Cancer 收起 <<	Phase 2	Recruiting	November 21, 2023	United States, California ... 展开 >> USC / Norris Comprehensive Cancer Center Recruiting Los Angeles, California, United States, 90033 Contact: Cheryl Kefauver, RN 323-865-0459 Cheryl.Kefauver@med.usc.edu Principal Investigator: David I Quinn, MD Cedars Sinai Medical Center Not yet recruiting Los Angeles, California, United States, 90048 Contact: Edwin M. Posadas 310-423-7600 Edwin.posadas@csmc.edu Principal Investigator: Edwin M. Posadas 收起 <<
NCT02215096	Cancer	Phase 1	Recruiting	December 2, 2019	United States, California ... 展开 >> GSK Investigational Site Completed Duarte, California, United States, 91010 GSK Investigational Site Completed Los Angeles, California, United States, 90089 GSK Investigational Site Recruiting Los Angeles, California, United States, 90095 Contact: US GSK Clinical Trials Call Center 877-379-3718 GSKClinicalSupportHD@gsk.com Contact: EU GSK Clinical Trials Call Center +44 (0) 20 8990 4466 GSKClinicalSupportHD@gsk.com United States, District of Columbia GSK Investigational Site Recruiting Washington, District of Columbia, United States, 20007 Contact: US GSK Clinical Trials Call Center 877-379-3718 GSKClinicalSupportHD@gsk.com Contact: EU GSK Clinical Trials Call Center +44 (0) 20 8990 4466 GSKClinicalSupportHD@gsk.com United States, Michigan GSK Investigational Site Recruiting Detroit, Michigan, United States, 48201 Contact: US GSK Clinical Trials Call Center 877-379-3718 GSKClinicalSupportHD@gsk.com Contact: EU GSK Clinical Trials Call Center +44 (0) 20 8990 4466 GSKClinicalSupportHD@gsk.com United States, New York GSK Investigational Site Completed New York, New York, United States, 10016 United States, Texas GSK Investigational Site Recruiting Houston, Texas, United States, 77030 Contact: US GSK Clinical Trials Call Center 877-379-3718 GSKClinicalSupportHD@gsk.com Contact: EU GSK Clinical Trials Call Center +44 (0) 20 8990 4466 GSKClinicalSupportHD@gsk.com United States, Utah GSK Investigational Site Terminated Salt Lake City, Utah, United States, 84112-5550 United Kingdom GSK Investigational Site Recruiting London, United Kingdom, SE1 9RT Contact: US GSK Clinical Trials Call Center 877-379-3718 GSKClinicalSupportHD@gsk.com Contact: EU GSK Clinical Trials Call Center +44 (0) 20 8990 4466 GSKClinicalSupportHD@gsk.com GSK Investigational Site Recruiting Sutton, United Kingdom, SM2 5PT Contact: US GSK Clinical Trials Call Center 877-379-3718 GSKClinicalSupportHD@gsk.com Contact: EU GSK Clinical Trials Call Center +44 (0) 20 8990 4466 GSKClinicalSupportHD@gsk.com 收起 <<
NCT02588001	Prostate Cancer	Not Applicable	Active, not recruiting	September 30, 2021	Japan ... 展开 >> Kagawa University Faculty of Medicine Kita-gun, Kagawa-prefecture, Japan, 761-0793 University of Miyazaki Faculty of Medicine Miyazaki-city, Miyazaki-prefecture, Japan, 889-1692 Tokyo Medical Center Meguro-ku, Tokyo, Japan, 152-8902 The Jikei university school of medicin Minato-ku, Tokyo, Japan, 105-8461 收起 <<
NCT03395197	mCRPC	Phase 3	Recruiting	November 2024	United States, Alaska ... 展开 >> Alaska Urological Institute dba Alaska Clinical Research Center Not yet recruiting Anchorage, Alaska, United States, 99503 United States, Arizona Urological Associates of Southern Arizona, PC Recruiting Tucson, Arizona, United States, 85715 Urological Associates of Southern Arizona, P.C. Recruiting Tucson, Arizona, United States, 85741 United States, California Marin Cancer Care, Inc. Not yet recruiting Greenbrae, California, United States, 94904 San Diego Clinical Trials Not yet recruiting San Diego, California, United States, 92120 United States, Colorado The Urology Center of Colorado Recruiting Denver, Colorado, United States, 80211 United States, Nebraska GU Research Network/Urology Cancer Center Recruiting Omaha, Nebraska, United States, 68130 United States, New Jersey New Jersey Urology, LLC Not yet recruiting Voorhees, New Jersey, United States, 08043 United States, New York Premier Medical Group of the Hudson Valley PC Not yet recruiting Poughkeepsie, New York, United States, 12601 Associated Medical Professionals of New York, PLLC Not yet recruiting Syracuse, New York, United States, 13210 United States, Ohio TriState urologic Services PSC Inc., dba The Urology Group Not yet recruiting Cincinnati, Ohio, United States, 45212 United States, South Carolina Carolina Urologic Research Center Recruiting Myrtle Beach, South Carolina, United States, 29572 United States, Tennessee Urology Associates P.C. Not yet recruiting Nashville, Tennessee, United States, 37209 United States, Utah University of Utah, Huntsman Cancer Hospital Recruiting Salt Lake City, Utah, United States, 84112 University of Utah, Huntsman Cancer Institute Recruiting Salt Lake City, Utah, United States, 84112 收起 <<
NCT01911728	Pharmacokinetics of MDV3100 ... 展开 >> Castration Resistant Prostate Cancer (CRPC) 收起 <<	Phase 1	Completed	-	South Africa ... 展开 >> Parexel George, South Africa Parexel/Qdot Pharma Port Elizabeth, South Africa 收起 <<
NCT01901133	Pharmacokinetics of MDV3100 ... 展开 >> Healthy Subjects Kidney Diseases 收起 <<	Phase 1	Completed	-	Moldova, Republic of ... 展开 >> Arensia Chisinau, Moldova, Republic of 收起 <<
NCT01995513	Prostate Cancer	Phase 4	Active, not recruiting	May 31, 2024	-
NCT02012296	Hormone-resistant Prostate Can... 展开 >>cer Recurrent Prostate Cancer Stage IV Prostate Cancer 收起 <<	Phase 1 Phase 2	Recruiting	December 1, 2021	United States, Illinois ... 展开 >> University of Chicago Comprehensive Cancer Center Recruiting Chicago, Illinois, United States, 60637-1470 Contact: Kelly O'Connor 773-702-4653 koconnor@medicine.bsd.uchicago.edu Principal Investigator: Russell Z. Szmulewitz Cancer Care Specialists of Central Illinois (Decatur) /Decatur Memorial Hospital Recruiting Decatur, Illinois, United States, 62526 Contact: James Wade, MD 217-876-6600 NorthShore University Health System Recruiting Evanston, Illinois, United States, 60201 Contact: Daniel Shevrin, MD 224-364-7100 dshevrin@northshore.org United States, Michigan Wayne State University Karmanos Cancer Institute Recruiting Detroit, Michigan, United States, 48201 Contact: Elisabeth Heath, MD 313-576-8624 heathe@karmanos.org 收起 <<
NCT02799745	Prostate Cancer	Phase 2	Active, not recruiting	August 2020	-
NCT01995513	-		Active, not recruiting	-	-
NCT02607228	Metastatic Castrate-Resistant ... 展开 >>Prostate Cancer 收起 <<	Phase 1 Phase 2	Active, not recruiting	December 2018	United States, California ... 展开 >> San Francisco, California, United States, 94158 United States, Maryland Baltimore, Maryland, United States, 21231 United States, Massachusetts Boston, Massachusetts, United States, 02114 United States, North Carolina Durham, North Carolina, United States, 27710 收起 <<
NCT02491411	Hormone-Resistant Prostate Can... 展开 >>cer Metastatic Prostate Carcinoma Prostate Adenocarcinoma Stage IV Prostate Cancer 收起 <<	Not Applicable	Terminated(The study is termin... 展开 >>ated due to lower enrollment) 收起 <<	-	United States, Maryland ... 展开 >> Johns Hopkins University/Sidney Kimmel Cancer Center Baltimore, Maryland, United States, 21287 收起 <<
NCT01885949	Prostate Cancer	Phase 2	Active, not recruiting	June 2019	United States, Massachusetts ... 展开 >> Massachusetts General Hospital Boston, Massachusetts, United States, 02114 收起 <<
NCT02125357	Metastatic Castration-Resistan... 展开 >>t Prostate Cancer 收起 <<	Phase 2	Active, not recruiting	July 2019	Canada, British Columbia ... 展开 >> BC Cancer Agency - Abbotsford Abbotsford, British Columbia, Canada, V2S 0C2 BC Cancer Agency - Southern Interior Kelowna, British Columbia, Canada, V1Y 5L3 BC Cancer Agency - Centre for the North Prince George, British Columbia, Canada, V2N 7E9 BC Cancer Agency - Fraser Valley Surrey, British Columbia, Canada, V3V 1Z2 Vancouver Prostate Centre Vancouver, British Columbia, Canada, V5Z 1M9 BC Cancer Agency - Vancouver Centre Vancouver, British Columbia, Canada, V5Z 4E6 BC Cancer Agency - Vancouver Island Victoria, British Columbia, Canada, V8R 6V5 收起 <<
NCT02833883	Prostate Cancer ... 展开 >> Castration Resistant Prostate Cancer 收起 <<	Phase 1	Recruiting	July 2019	United States, California ... 展开 >> University of California San Francisco Recruiting San Francisco, California, United States, 94143 Contact: Felix Feng, MD 415-502-7222 United States, Maryland John Hopkins Medical Center Recruiting Baltimore, Maryland, United States, 21287 Contact: Emmanuel Antonarakis, MBBCh 410-464-6641 Principal Investigator: Emmanuel Antonarakis, MBBCh United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Dana Rathkopf, MD 646-422-4379 Contact: Wassim Abida, MD, PhD 646-422-4633 Principal Investigator: Dana Rathkopf, MD United States, Washington University of Washington School of Medicine Recruiting Seattle, Washington, United States, 98109 Contact: Heather Cheng, MD, PhD 206-606-7486 Principal Investigator: Heather Cheng, MD, PhD 收起 <<
NCT02749903	Salivary Cancer	Phase 2	Active, not recruiting	-	-
NCT01091103	Metastatic Progressive Castrat... 展开 >>ion-resistant Prostate Cancer 收起 <<	Phase 2	Completed	-	United States, Texas ... 展开 >> MD Anderson Cancer Center Houston, Texas, United States, 77303 收起 <<
NCT02669771	-		Active, not recruiting	November 2018	Japan ... 展开 >> Aichi, Japan Akita, Japan Aomori, Japan Chiba, Japan Ehime, Japan Fukui, Japan Fukuoka, Japan Fukushima, Japan Gifu, Japan Gunma, Japan Hiroshima, Japan Hokkaido, Japan Hyogo, Japan Ibaraki, Japan Ishikawa, Japan Iwate, Japan Kagawa, Japan Kagoshima, Japan Kanagawa, Japan Kochi, Japan Kumamoto, Japan Kyoto, Japan Mie, Japan Miyagi, Japan Miyazaki, Japan Nagano, Japan Nagasaki, Japan Nara, Japan Niigata, Japan Oita, Japan Okayama, Japan Okinawa, Japan Osaka, Japan Saga, Japan Saitama, Japan Shiga, Japan Shimane, Japan Shizuoka, Japan Tochigi, Japan Tokushima, Japan Tokyo, Japan Tottori, Japan Toyama, Japan Wakayama, Japan Yamagata, Japan Yamaguchi, Japan Yamanashi, Japan 收起 <<
NCT02885649	Clear Cell Renal Cell Carcinom... 展开 >>a Stage I Renal Cell Cancer 收起 <<	Early Phase 1	Recruiting	January 2020	United States, New Jersey ... 展开 >> Rutgers Cancer Institute of New Jersey Recruiting New Brunswick, New Jersey, United States, 08903 Contact: Eric A. Singer 732-235-8675 singerea@cinj.rutgers.edu Principal Investigator: Eric A. Singer 收起 <<
NCT02491411	-		Terminated(The study is termin... 展开 >>ated due to lower enrollment) 收起 <<	-	-
NCT01091103	-		Completed	-	-
NCT02640534	Cancer of the Prostate ... 展开 >> Prostate Cancer 收起 <<	Phase 2	Recruiting	June 2026	Switzerland ... 展开 >> Kantonsspital Aarau Recruiting Aarau, Switzerland, 5001 Contact: Tobias Wehrhahn, Dr. med. +41 62 838 60 50 tobias.wehrhahn@ksa.ch Principal Investigator: Tobias Wehrhahn, Dr. med. Universitaetsspital Basel Recruiting Basel, Switzerland, 4031 Contact: Sacha Rothschild, MD +41 61 265 25 25 sacha.rothschild@usb.ch Principal Investigator: Sacha Rothschild, MD Istituto Oncologico della Svizzera Italiana (IOSI) Recruiting Bellinzona, Switzerland, 6500 Contact: Ricardo Pereira Mestre, MD +41 91 811 84 46 ricardo.pereiramestre@eoc.ch Principal Investigator: Ricardo Pereira Mestre, MD Kantonsspital Graubuenden Recruiting Chur, Switzerland, 7000 Contact: Richard Cathomas, MD +41 81 256 66 95 richard.cathomas@ksgr.ch Principal Investigator: Richard Cathomas, MD Spital Thurgau AG Recruiting Frauenfeld, Switzerland, CH-8500 Contact: Regina Woelkly, MD +41 52 723 76 91 regina.woelkly@stgag.ch Principal Investigator: Regina Woelkly, MD Hôpitaux Universitaires de Genève Recruiting Genève 14, Switzerland, 1211 Contact: Anna Patrikidou, MD +41 79 553 60 99 anna.patrikidou@hcuge.ch Principal Investigator: Anna Patrikidou, MD CCAC Lausanne Recruiting Lausanne, Switzerland, 1004 Contact: Pierre Bohanes, MD +41 (21) 646 79 94 pbohanes@bluewin.ch Principal Investigator: Pierre Bohanes, MD Luzerner Kantonsspital Recruiting Luzern 16, Switzerland, 6000 Contact: Beat Müller, MD +41 41 205 58 60 beat.mueller@luks.ch Principal Investigator: Beat Müller, MD Hôpital du Valais Recruiting Martigny, Switzerland, 1920 Contact: Sandro Anchisi, MD +41 27 603 90 00 sandro.anchisi@hopitalvs.ch Principal Investigator: Sandro Anchisi, MD Kantonsspital Olten Recruiting Olten, Switzerland, CH-4600 Contact: Walter Mingrone, MD 41-62-311-4241 wmingrone_ol@spital.ktso.ch Principal Investigator: Walter Mingrone, MD Hôpital du Valais Recruiting Sion, Switzerland, 1951 Contact: Sandro Anchisi, MD +41 27 603 45 00 sandro.anchisi@hopitalvs.ch Principal Investigator: Sandro Anchisi, MD Bürgerspital Solothurn Recruiting Solothurn, Switzerland, CH-4500 Contact: Philippe von Burg, MD +41 32 627 47 00 philippe.vonburg@spital.so.ch Principal Investigator: Philippe von Burg, MD Kantonsspital St. Gallen Recruiting St. Gallen, Switzerland, 9007 Contact: Christian Rothermundt, MD +41 71 494 11 63 christian.rothermundt@kssg.ch Principal Investigator: Christian Rothermundt, MD Kantonsspital Winterthur Recruiting Winterthur, Switzerland, 8401 Contact: Natalie Fischer, MD +41 052 266 40 87 natalie.fischer@ksw.ch Principal Investigator: Natalie Fischer, MD Stadtspital Triemli Recruiting Zürich, Switzerland, 8063 Contact: Aleksandra Marek, Dr. med. +41 (44) 466 11 11 aleksandra.marek@triemli.zuerich.ch Principal Investigator: Aleksandra Marek, Dr. med. UniversitätsSpital Zürich Recruiting Zürich, Switzerland, 8091 Contact: Thomas Hermanns, MD +41 44 255 11 11 thomas.hermanns@usz.ch Principal Investigator: Thomas Hermanns, MD 收起 <<
NCT02935205	Metastatic Prostate Carcinoma ... 展开 >> Recurrent Prostate Carcinoma Stage IV Prostate Cancer 收起 <<	Phase 1 Phase 2	Recruiting	December 2020	United States, California ... 展开 >> University of California Davis Comprehensive Cancer Center Recruiting Sacramento, California, United States, 95817 Contact: Chong-Xian Pan 916-734-3771 cxpan@ucdavis.edu Principal Investigator: Chong-Xian Pan 收起 <<
NCT02555189	Hormone-Resistant Prostate Can... 展开 >>cer Metastatic Prostate Carcinoma Prostate Carcinoma Metastatic in the Bone Stage IV Prostate Cancer 收起 <<	Phase 1 Phase 2	Recruiting	May 2021	United States, Michigan ... 展开 >> University of Michigan Comprehensive Cancer Center Recruiting Ann Arbor, Michigan, United States, 48109 Contact: David Smith, MD 734-763-6537 United States, New York Roswell Park Cancer Institute Recruiting Buffalo, New York, United States, 14263 Contact: Gurkamal Chatta, MD Gurkamal.Chatta@RoswellPark.org Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Susan Slovin, MD, PhD 646-422-4470 United States, Pennsylvania Thomas Jefferson University Recruiting Philadelphia, Pennsylvania, United States, 19107 Contact: William Kevin Kelly, MD 215-955-8874 Contact: Clinical Trials Office 215-955-1661 Principal Investigator: William Kevin Kelly, MD Sub-Investigator: Robert Den, MD Sub-Investigator: Jean Hoffman-Censits, MD Sub-Investigator: Jianqing Lin, MD Sub-Investigator: Leonard Gomella, MD Sub-Investigator: Edouard Trabulsi, MD Sub-Investigator: Costas Lallas, MD 收起 <<
NCT03704519	Cerebrovascular Circulation	Phase 1	Recruiting	July 24, 2019	United Kingdom ... 展开 >> Academic Neuroscience Centre, Kings College Recruiting London, United Kingdom, SE5 8AF 收起 <<
NCT02091960	-		Active, not recruiting	-	-
NCT02091960	HER2 Amplified ... 展开 >> Advanced Breast Cancer Human Epidermal Growth Factor Receptor 2 (HER2) 收起 <<	Phase 2	Active, not recruiting	December 2019	-
NCT01547299	Prostate Cancer	Phase 2	Completed	-	United States, Massachusetts ... 展开 >> Boston, Massachusetts, United States, 02215 United States, Washington Seattle, Washington, United States, 98195 Canada, British Columbia Vancouver, British Columbia, Canada, V5Z 1M9 Canada, Ontario Toronto, Ontario, Canada, M5G 2M9 收起 <<
NCT01547299	-		Completed	-	-
NCT02339168	Prostate Cancer	Phase 1	Active, not recruiting	December 2019	United States, California ... 展开 >> University of California Davis Comprehensive Cancer Center Sacramento, California, United States, 95817 收起 <<
NCT02099864	Castration Levels of Testoster... 展开 >>one Castration-Resistant Prostate Carcinoma Metastatic Prostate Carcinoma in the Soft Tissue Metastatic Prostatic Adenocarcinoma Prostate Carcinoma Metastatic in the Bone PSA Progression Recurrent Prostate Carcinoma Stage III Prostate Adenocarcinoma Stage IV Prostate Adenocarcinoma 收起 <<	Not Applicable	Active, not recruiting	August 31, 2020	United States, California ... 展开 >> UCSF Medical Center-Mount Zion San Francisco, California, United States, 94115 United States, Oregon OHSU Knight Cancer Institute Portland, Oregon, United States, 97239 收起 <<
NCT01597193	Breast Cancer	Phase 1	Completed	-	United States, Colorado ... 展开 >> ATTN-Research Pharmacist Aurora, Colorado, United States, 80045 University of Colorado Cancer Center Aurora, Colorado, United States, 80045 University of Colorado Hospital, Anschutz Outpatient Pavilion Aurora, Colorado, United States, 80045 United States, Connecticut Connecticut Multispecialty Group Enfield, Connecticut, United States, 06082 United States, Florida Florida Cancer Specialists Sarasota, Florida, United States, 34232 United States, Michigan Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Mississippi The West Clinic, PC Corinth, Mississippi, United States, 38834 The West Clinic Southaven, Mississippi, United States, 38671 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10022 Memorial Sloan Kettering Cancer Center - IDS Pharmacy New York, New York, United States, 10065 Memorial Sloan Kettering Cancer Center - OPD Pharmacy New York, New York, United States, 10065 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 United States, Tennessee The West Clinic Germantown, Tennessee, United States, 38138 The West Clinic Memphis, Tennessee, United States, 38104 The West Clinic Memphis, Tennessee, United States, 38120 Tennessee Oncology, PLLC. Nashville, Tennessee, United States, 37203 The Sarah Cannon Research Institute Nashville, Tennessee, United States, 37203 收起 <<
NCT02007512	-		Active, not recruiting	-	-
NCT01663415	Metastatic Castration-Resistan... 展开 >>t Prostate Cancer 收起 <<	Phase 2	Withdrawn(A business decision ... 展开 >>was made to not initiate this study.) 收起 <<	October 2014	-
NCT02057939	Prostate Cancer	Phase 2	Active, not recruiting	March 2019	United States, New Jersey ... 展开 >> Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, North Carolina Duke University Medical Center Durham, North Carolina, United States, 27710 Wake Forest Baptist Health Winston-Salem, North Carolina, United States, 27157 收起 <<
NCT02489123	Ann Arbor Stage I Mantle Cell ... 展开 >>Lymphoma Ann Arbor Stage II Mantle Cell Lymphoma Ann Arbor Stage III Mantle Cell Lymphoma Ann Arbor Stage IV Mantle Cell Lymphoma Recurrent Mantle Cell Lymphoma Refractory Mantle Cell Lymphoma 收起 <<	Not Applicable	Recruiting	-	United States, Washington ... 展开 >> Fred Hutch/University of Washington Cancer Consortium Recruiting Seattle, Washington, United States, 98109 Contact: Ajay K. Gopal 206-606-2037 agopal@uw.edu Principal Investigator: Ajay K. Gopal 收起 <<
NCT02452008	Prostate Cancer	Phase 2	Recruiting	July 2021	United States, District of Col... 展开 >>umbia Sibley Memorial Hospital Recruiting Washington, District of Columbia, United States, 20016 Contact: Janice Powers, RN 202-660-5772 jpower22@JHMI.EDU Principal Investigator: Channing Paller, MD United States, Illinois Northwestern University Recruiting Chicago, Illinois, United States, 60611 Contact: Maha Hussain, MD 312-908-5487 maha.hussain@northwestern.edu Principal Investigator: Maha Hussain, MD University of Chicago Recruiting Chicago, Illinois, United States, 60637 Contact: Russel Szmulewitz, MD 773-702-7609 rszmulew@medicine.bsd.uchicago.edu Contact: Kelly O'Connor 773-702-4653 koconnor@medicine.bsd.uchicago.edu Principal Investigator: Russel Szmulewitz, MD United States, Maryland Johns Hopkins University Recruiting Baltimore, Maryland, United States, 21205 Contact: Channing Paller, MD 410-614-6321 cpaller@JHMI.EDU Contact: Irina Rifkind, RN 410-502-2043 irifkin1@JHMI.EDU Principal Investigator: Channing Paller, MD 收起 <<
NCT03709550	Castration Levels of Testoster... 展开 >>one Castration-Resistant Prostate Carcinoma Metastatic Prostate Carcinoma in the Soft Tissue Prostate Carcinoma Metastatic in the Bone PSA Level Greater Than or Equal to Two PSA Progression Stage IV Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8 Stage IVB Prostate Cancer AJCC v8 收起 <<	Phase 1 Phase 2	Not yet recruiting	August 31, 2020	United States, New York ... 展开 >> Roswell Park Cancer Institute Not yet recruiting Buffalo, New York, United States, 14263 Contact: Gurkamal S. Chatta 716-845-3117 Gurkamal.Chatta@roswellpark.org Principal Investigator: Gurkamal S. Chatta 收起 <<
NCT02689427	Breast Cancer	Phase 2	Recruiting	September 2021	United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 收起 <<
NCT01302041	-		Completed	-	-
NCT01889238	Advanced, Androgen Receptor Po... 展开 >>sitive Triple Negative Breast Cancer 收起 <<	Phase 2	Active, not recruiting	June 30, 2019	-
NCT02642913	Hepatocellular Carcinoma	Phase 1 Phase 2	Recruiting	December 2019	United States, California ... 展开 >> University of California San Francisco Recruiting San Francisco, California, United States, 94143 Contact: Robin K Kelley, MD 415-353-9888 United States, Missouri Washington University School of Medicine Recruiting Saint Louis, Missouri, United States, 63110 Contact: Benjamin Tan, MD 314-747-7222 Principal Investigator: Benjamin Tan, MD United States, New York Roswell Park Cancer Institute Recruiting Buffalo, New York, United States, 14263-0001 Contact: Iyer Renuka, MD 716-845-2300 Memorial Sloan Kettering Westchester Recruiting Harrison, New York, United States, 10604 Contact: James Harding, MD 646-888-4314 Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: James Harding, MD 646-888-4314 Contact: Ghassan Abou-Alfa, MD 646-888-4184 收起 <<
NCT01889238	-		Active, not recruiting	-	-
NCT01664923	Prostate Cancer	Phase 2	Completed	-	-
NCT02007512	Breast Cancer	Phase 2	Active, not recruiting	March 29, 2019	-
NCT01664923	-		Completed	-	-
NCT02294461	Progressive Metastatic Prostat... 展开 >>e Cancer 收起 <<	Phase 3	Active, not recruiting	March 2020	-
NCT03751436	Castration Levels of Testoster... 展开 >>one Castration-Resistant Prostate Carcinoma Metastatic Prostate Carcinoma Metastatic Prostate Carcinoma in the Soft Tissue Prostate Carcinoma Metastatic in the Bone PSA Progression Stage IV Prostate Cancer AJCC v8 Stage IVA Prostate Cancer AJCC v8 Stage IVB Prostate Cancer AJCC v8 收起 <<	Phase 1 Phase 2	Not yet recruiting	September 2022	United States, New York ... 展开 >> Roswell Park Cancer Institute Not yet recruiting Buffalo, New York, United States, 14263 Contact: Gurkamal S. Chatta 716-845-3117 Gurkamal.Chatta@roswellpark.org Principal Investigator: Gurkamal S. Chatta 收起 <<
NCT02064582	Prostate Cancer	Phase 2	Active, not recruiting	April 2019	United States, Texas ... 展开 >> UT Southwestern Medical Center Dallas, Texas, United States, 75390 收起 <<
NCT02294461	-		Active, not recruiting	-	-
NCT02955394	Breast Cancer	Phase 2	Recruiting	November 2018	United States, Colorado ... 展开 >> University of Colorado Recruiting Aurora, Colorado, United States, 80045 Contact: Tiffany Colvin 720-848-0664 tiffany.colvin@ucdenver.edu Principal Investigator: Anthony D Elias, MD United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States, 10065 Contact: Monica Fornier, MD fornierm@mskcc.org Principal Investigator: Monica Fornier, MD United States, Tennessee West Cancer Center Recruiting Germantown, Tennessee, United States, 38138 Contact: Gregory Vidal, MD gvidal@westclinic.com Principal Investigator: Gregory Vidal, MD 收起 <<
NCT02750358	Breast Cancer ... 展开 >> Early Stage Triple Negative Breast Cancer 收起 <<	Phase 2	Active, not recruiting	May 2019	United States, Connecticut ... 展开 >> Hartford Healthcare Cancer Institute @ Hartford Hospital Hartford, Connecticut, United States, 06102 United States, New Jersey Memorial Sloan Kettering Cancer Center Basking Ridge, New Jersey, United States, 07920 Memorial Sloan Kettering Monmouth Middletown, New Jersey, United States, 07748 United States, New York Kings County Hopsital Center Brooklyn, New York, United States, 11203 Coney Island Hospital Brooklyn, New York, United States, 11235 Woodhull Hospital Brooklyn, New York, United States Memorial Sloan Kettering Cancer Center at Commack Commack, New York, United States, 11725 Memorial Sloan Kettering Westchester Harrison, New York, United States, 10604 Queens Hospital Center Jamaica, New York, United States, 11432 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Memorial Sloan-Kettering Cancer Center at Mercy Medical Center Rockville Centre, New York, United States, 11570 United States, Pennsylvania Lehigh Valley Health Network Allentown, Pennsylvania, United States, 18103 收起 <<
NCT01302041	Prostate Cancer	Phase 2	Completed	-	Belgium ... 展开 >> Site BE1003 Brussels, Belgium, 1090 Site BE1001 Brussels, Belgium, 1200 Site BE1002 Kortrijk, Belgium, 8500 Site BE1005 Leuven, Belgium, 3000 Czechia Site CZ3006 Olomouc, Czechia, 77520 Site CZ3002 Praha 6, Czechia, 16000 Denmark Site DK4001 Aarhus N, Denmark, 8200 Site DK4004 Copenhagen, Denmark, DK-2100 Site DK4002 Herlev, Denmark, 2730 Germany Site DE5005 Aachen, Germany, 51074 Site DE5007 Bonn, Germany, 53111 Site DE5003 Hannover, Germany, 30625 收起 <<
NCT01974765	Advanced Epithelial Ovarian ... 展开 >> Recurrent Epithelial Ovarian Fallopian Tube Primary Peritoneal Carcinoma 收起 <<	Phase 2	Active, not recruiting	October 2019	United States, New Jersey ... 展开 >> Memorial Sloan Kettering Cancer Center at Basking Ridge Basking Ridge, New Jersey, United States Memorial Sloan Kettering Monmouth Middletown, New Jersey, United States, 07748 United States, New York Memorial Sloan Kettering Cancer Center @ Suffolk Commack, New York, United States, 11725 Memorial Sloan Kettering Westchester Harrison, New York, United States, 10604 Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 Memorial Sloan Kettering Cancer Center at Mercy Medical Center Rockville Centre, New York, United States, 11570 收起 <<
NCT02918968	Prostate Cancer	Phase 4	Active, not recruiting	March 2020	Japan ... 展开 >> Site JP00024 Aichi, Japan Site JP00025 Aichi, Japan Site JP00010 Chiba, Japan Site JP00053 Chiba, Japan Site JP00038 Ehime, Japan Site JP00039 Fukuoka, Japan Site JP00040 Fukuoka, Japan Site JP00050 Fukuoka, Japan Site JP00051 Fukuoka, Japan Site JP00005 Gunma, Japan Site JP00043 Gunma, Japan Site JP00045 Gunma, Japan Site JP00035 Hiroshima, Japan Site JP00001 Hokkaido, Japan Site JP00002 Hokkaido, Japan Site JP00048 Hokkaido, Japan Site JP00054 Hokkaido, Japan Site JP00055 Ibaraki, Japan Site JP00019 Kanagawa, Japan Site JP00020 Kanagawa, Japan Site JP00021 Kanagawa, Japan Site JP00044 Kanagawa, Japan Site JP00026 Kyoto, Japan Site JP00006 Nagano, Japan Site JP00008 Nagano, Japan Site JP00041 Nagasaki, Japan Site JP00046 Nara, Japan Site JP00033 Okayama, Japan Site JP00027 Osaka, Japan Site JP00028 Osaka, Japan Site JP00029 Osaka, Japan Site JP00030 Osaka, Japan Site JP00031 Osaka, Japan Site JP00032 Osaka, Japan Site JP00042 Saga, Japan Site JP00009 Saitama, Japan Site JP00022 Shizuoka, Japan Site JP00049 Tochigi, Japan Site JP00037 Tokushima, Japan Site JP00011 Tokyo, Japan Site JP00013 Tokyo, Japan Site JP00014 Tokyo, Japan Site JP00016 Tokyo, Japan Site JP00017 Tokyo, Japan Site JP00018 Tokyo, Japan Site JP00052 Toyama, Japan Site JP00034 Yamaguchi, Japan 收起 <<
NCT01977651	Metastatic Castration-resistan... 展开 >>t Prostate Cancer (mCRPC) 收起 <<	Phase 4	Active, not recruiting	November 2018	-
NCT02203695	Adenocarcinoma of the Prostate	Phase 2	Recruiting	August 2025	United States, District of Col... 展开 >>umbia Sibley Memorial Hospital Recruiting Washington, District of Columbia, United States, 20016 Contact: Ashley Bruns 202-537-4000 abruns3@jhmi.edu United States, Illinois University of Chicago Medical Center Recruiting Chicago, Illinois, United States, 60637 Contact: Fauzia Arif farif@radonc.uchicago.edu United States, Indiana Indiana University Not yet recruiting Lafayette, Indiana, United States, 47904 Contact: Stephanie Middleton 765-838-6871 smiddle3@iuhealth.org United States, Maryland The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins Recruiting Baltimore, Maryland, United States, 21287 Sub-Investigator: Charles Drake, M.D. Sub-Investigator: Hans Hammers, M.D. Sub-Investigator: Emmanuel Antonarakis, M.D. Sub-Investigator: Samuel Denmeade, M.D. Sub-Investigator: Channing Pallar, M.D. Sub-Investigator: Hao Wang, Ph.D. Sub-Investigator: Danny Song, M.D. Sub-Investigator: Mario Eisenberger, M.D. Sub-Investigator: Michael Carducci, M.D. Sub-Investigator: Theodore DeWeese, M.D. Suburban Hospital Recruiting Bethesda, Maryland, United States, 20814 Contact: Barbara Squiller 301-896-2719 bsquill1@jhmi.edu United States, Michigan University of Michigan Health System Recruiting Ann Arbor, Michigan, United States, 48109 Contact: Carolina Fernandez-Castillo cefernan@med.umich.edu Contact: Charles Leister cleister@med.umich.edu Karmanos Cancer Center Recruiting Detroit, Michigan, United States, 48201 Contact: Ted Chaperon chaperon@karmanos.org Principal Investigator: Peter Paximadis Sub-Investigator: Elisabeth Heath United States, Oregon Oregon Health Sciences University Recruiting Portland, Oregon, United States, 97239 Contact: Ryan Stewart stewarry@ohsu.edu Principal Investigator: Arthur Hung United States, Utah University of Utah - Huntsman Cancer Center Not yet recruiting Salt Lake City, Utah, United States, 84112 收起 <<
NCT02003924	Nonmetastatic Castration-Resis... 展开 >>tant Prostate Cancer Prostate Cancer Cancer of the Prostate 收起 <<	Phase 3	Active, not recruiting	May 31, 2020	-
NCT02677896	Metastatic Hormone Sensitive P... 展开 >>rostate Cancer 收起 <<	Phase 3	Active, not recruiting	December 2023	-
NCT02605863	Bladder Cancer	Phase 2	Terminated(Low enrollment, spo... 展开 >>nsor withdrew support for study) 收起 <<	-	United States, New York ... 展开 >> University of Rochester Rochester, New York, United States, 14642 收起 <<
NCT02429193	Castration-resistant Prostate ... 展开 >>Cancer 收起 <<	Phase 2	Active, not recruiting	June 2018	Canada, British Columbia ... 展开 >> British Columbia Cancer Agency, Vancouver Cancer Centre Vancouver, British Columbia, Canada, V5Z 4E6 Canada, Ontario Princess Margaret Cancer Centre Toronto, Ontario, Canada, M5G 2M9 收起 <<
NCT03700099	Prostate Cancer ... 展开 >> Castration-resistant Prostate Cancer 收起 <<	Phase 2	Not yet recruiting	December 2021	Brazil ... 展开 >> Instituto do Câncer do Estado de São Paulo Not yet recruiting São Paulo, SP, Brazil Contact: Ingrid Barbosa +55 11 3893-3535 ingrid.barbosa@hc.fm.usp.br Principal Investigator: Diogo Assed Bastos, MD 收起 <<
NCT02605863	-		Terminated(Low enrollment, spo... 展开 >>nsor withdrew support for study) 收起 <<	-	-
NCT02711956	Metastatic Castration-Resistan... 展开 >>t Prostate Cancer 收起 <<	Phase 1 Phase 2	Recruiting	June 2019	United States, California ... 展开 >> University of California Los Angeles Medical Center Recruiting Los Angeles, California, United States University of California San Francisco Medical Center Recruiting San Francisco, California, United States United States, Michigan Karmanos Cancer Institute Recruiting Detroit, Michigan, United States Karmanos Cancer Institute Recruiting Farmington Hills, Michigan, United States United States, New York Memorial Sloan Kettering Cancer Center Recruiting New York, New York, United States Weill Cornell Medicine - New York Presbyterian Recruiting New York, New York, United States United States, Oregon Oregon Health & Science University Recruiting Portland, Oregon, United States United States, Washington Seattle Cancer Care Alliance Recruiting Seattle, Washington, United States 收起 <<
NCT03464201	Ovarian Cancer	Phase 2	Recruiting	March 2020	Spain ... 展开 >> Hospital de Mar Recruiting Barcelona, Spain Hospital Reina Sofia Recruiting Córdoba, Spain Hospital Madrid Sanchinarro (CIOCC) Recruiting Madrid, Spain Contact: Garcia-Donas, MD +34 91 756 79 84 jgarciadonas@gmail.com Hospital Universitario La Paz Recruiting Madrid, Spain Hospital Son Llatzer Recruiting Palma De Mallorca, Spain Hospital de Navarra Recruiting Pamplona, Spain Complejo Hospitalario Universitario de Santiago Recruiting Santiago De Compostela, Spain Hospital La Fe Not yet recruiting Valencia, Spain 收起 <<
NCT02441517	-		Terminated(The study is closed... 展开 >> early due to lck of enrollment.) 收起 <<	-	-
NCT02929576	Breast Cancer	Phase 3	Withdrawn(Further understandin... 展开 >>g about the role of androgen signaling in TNBC was required) 收起 <<	-	United States, Kansas ... 展开 >> Topeka, Kansas, United States, 66606 United States, Louisiana Metairie, Louisiana, United States, 70006 United States, New York Bronx, New York, United States, 10469 United States, Texas Houston, Texas, United States, 77030 United States, Washington Tacoma, Washington, United States, 98405 Wenatchee, Washington, United States, 98801 收起 <<
NCT02960022	Prostate Cancer	Phase 2	Recruiting	July 2021	-
NCT02288936	Hormone-refractory Prostate Ca... 展开 >>ncer 收起 <<	Phase 2	Active, not recruiting	January 2019	Spain ... 展开 >> Hospital Universitari Germans Trias I Pujol de Badalona Badalona, Barcelona, Spain, 08916 Hospital Universitari Son Espases Palma de Mallorca, Islas Baleares, Spain, 07120 Hospital Clinic I Provincial de Barcelona Barcelona, Spain, 08036 Hospital Parc Taulí Barcelona, Spain Complejo Hospitalario Regional Reina Sofía Córdoba, Spain, 14004 Complejo Asistencial Universitario de Leon León, Spain, 24080 Hospital Universitario Lucus Augusti Lugo, Spain, 27003 Hospital Ramón Y Cajal Madrid, Spain, 28034 Hospital Clínico San Carlos Madrid, Spain, 28040 Hospital Universitario 12 de Octubre Madrid, Spain, 28041 Hospital General Universitario J.M. Morales Meseguer Murcia, Spain, 30008 Complejo Hospitalario de Especialidades Virgen de La Victoria Málaga, Spain, 29010 Complexo Hospitalario Universitario de Ourense Ourense, Spain, 32005 Complejo Hospitalario Regional Virgen Del Rocio Sevilla, Spain, 41013 Fundación Instituto Valenciano de Oncologia Valencia, Spain, 46009 Hospital Universitario Miguel Servet Zaragoza, Spain, 50009 收起 <<
NCT03016312	Prostatic Neoplasms, Castratio... 展开 >>n-Resistant 收起 <<	Phase 3	Active, not recruiting	July 9, 2022	-
NCT03297385	Prostate Cancer ... 展开 >> DNA Androgen Receptor Abnormal 收起 <<	Phase 2	Completed	-	-
NCT03123978	Metastatic Prostate Carcinoma ... 展开 >> Recurrent Prostate Carcinoma Stage IV Prostate Cancer 收起 <<	Phase 1	Recruiting	January 2021	United States, California ... 展开 >> University of California Davis Comprehensive Cancer Center Recruiting Sacramento, California, United States, 95817 Contact: Chong-Xian Pan 916-734-3771 cxpan@ucdavis.edu Principal Investigator: Chong-Xian Pan 收起 <<
NCT01911741	Healthy Subjects ... 展开 >> Castration Resistant Prostate Cancer (CRPC) Relative Bioavailability MDV3100 收起 <<	Phase 1	Completed	-	Germany ... 展开 >> Parexel International GmbH Berlin, Germany, 14050 收起 <<
NCT02441517	Metastatic Castration Resistan... 展开 >>t Prostate Cancer 收起 <<	Phase 4	Terminated(The study is closed... 展开 >> early due to lck of enrollment.) 收起 <<	-	United States, Illinois ... 展开 >> Site US10003 Evanston, Illinois, United States, 60201 United States, Massachusetts Site US10006 Worcester, Massachusetts, United States, 01605 United States, New York Site US10004 New York, New York, United States, 10029 United States, South Carolina Site US10001 Charleston, South Carolina, United States, 29425 Site US10002 Myrtle Beach, South Carolina, United States, 29572 收起 <<
NCT02922218	-		Recruiting	December 2020	Spain ... 展开 >> Hospital Arquitecto Marcide Recruiting Ferrol, A Coruña, Spain, 15405 Contact: Javier Afonso, MD +34981334000 Franciso.Javier.Afonso.Afonso@sergas.es Hospital Universitario de Santiago Recruiting Santiago de Compostela, A Coruña, Spain, 15706 Contact: Urbano Anido, MD +34981950000 urbanoanido@gmail.com ICO L'Hospitalet Recruiting L'Hospitalet de Llobregat, Barcelona, Spain, 08907 Contact: Josep M. Piulats, MD +34932607780 jmpiulats@iconcologia.net Hospital Althaia Manresa Recruiting Manresa, Barcelona, Spain, 08243 Contact: Montserrat Domenech, MD +34938759300 ext 3309 mdomenech@althaia.cat Hospital de Especialidades de Jerez de la Frontera Recruiting Jerez de la Frontera, Cádiz, Spain, 11407 Contact: Ruth Viciana, MD +34956032075 ruthvician@gmail.com Hospital Costa del Sol Recruiting Marbella, Málaga, Spain, 29603 Contact: Rosa Villatoro, MD +34951976470 villatororoldan@gmail.com Complejo Hospitalario de Navarra Recruiting Pamplona, Navarra, Spain, 31008 Contact: Nuria Lainez, MD +34948255400 ext 5870 nuria.lainez.milagro@cfnavarra.es Hospital Universitario de Canarias Recruiting La Laguna, Tenerife, Spain, 38320 Contact: Rosa Delia Garcia, MD +34922678204 rdgmarrero@gmail.com Fundacion Centro Oncologico de Galicia Recruiting A Coruna, Spain, 15009 Contact: Ana Medina, MD +34981287499 ext 174 ana.medina@cog.es Hospital Universitario Vall D'Hebron Recruiting Barcelona, Spain, 08035 Contact: Rafael Morales, MD +34932746000 ext 4695 rafael.morales.barrera@gmail.com Hospital de Burgos Recruiting Burgos, Spain, 09006 Contact: Guillermo Crespo, MD +34947281978 rescribano@seom.org Contact: Ricardo Sanchez, MD +34947281978 rescribano@seom.org Hospital de Ciudad Real Recruiting Ciudad Real, Spain, 13005 Contact: Jose Carlos Villa, MD +34926278000 ext 77137 jvillaguzman1@yahoo.es Hospital Universitario Reina Sofia Recruiting Cordoba, Spain, 14004 Contact: Maria Jose Mendez, MD +34957011147 mjosemv@yahoo.es Hospital Universitario Virgen de las Nieves Recruiting Granada, Spain, 18014 Contact: Raquel Luque, MD +34958020000 rluquecaro@gmail.com Hospital Universitario de Guadalajara Recruiting Guadalajara, Spain, 19002 Contact: Javier Casinello, MD +34949209200 jacaes@sescam.jccm.es Hospital Universitario Gregorio Maranon Recruiting Madrid, Spain, 28007 Contact: Jose Angel Arranz, MD +34914269070 jarranz@oncomed.gmail.com Coordination PROCURE-Centro Nacional de Investigaciones Oncologicas Recruiting Madrid, Spain, 28029 Contact: Nuria Romero, MD 347328000 ext 2951 nromerol@cnio.es Contact: Berta Nasarre, PhD bnasarre@cnio.es Sub-Investigator: Leticia Rivera, CRA senior Sub-Investigator: Gala Grau, PhD Sub-Investigator: Maria Isabel Pacheco, Technician Sub-Investigator: Teresa Garces, Technician Hospital Universitario Clinico San Carlos Recruiting Madrid, Spain, 28040 Contact: Javier Puente, MD +34913303000 ext 7332 docjavip@yahoo.es Hospital Universitario 12 de Octubre Recruiting Madrid, Spain, 28041 Contact: Daniel Castellanos, MD +34913908339 cdanicas@hotmail.com Centro Integral Oncologico Clara Campal Recruiting Madrid, Spain, 28050 Contact: Elena Castro, MD +34917328000 ext 2950 ecastro@hmhospitales.com Hospital Regional Universitario Virgen de la Victoria Recruiting Malaga, Spain, 29010 Contact: Maria Isabel Medina, MD +34951291425 msaez.med@gmail.com Hospital Morales Messeguer Recruiting Murcia, Spain, 30008 Contact: Enrique Gonzalez, MD +34968360900 ext 3807 engonbil@um.es Hospital Virgen de la Victoria Recruiting Málaga, Spain, 29010 Contact: David Olmos, MD 34 91 732 8000 ext 2950 dolmos@cnio.es Contact: Gala Grau, PhD 34697959726 gala.gala.grau.eecc@gmail.com Hospital Son Espases Recruiting Palma de Mallorca, Spain, 07120 Contact: Aranzazu Gonzalez, MD +34871206130 ext 76130 aranzazu.gonzalezdealba@ssib.es Complejo Hospitalario de Pontevedra Recruiting Pontevedra, Spain, 36002 Contact: Cristina Azpitarte, MD +34 986800004 crisazpi@hotmail.com Hospital Universitario La Fe Recruiting Valencia, Spain, 46026 Contact: David Lorente, MD +34961244000 davlorente@hotmail.com 收起 <<
NCT03177187	Metastatic Castration Resistan... 展开 >>t Prostate Cancer 收起 <<	Phase 1 Phase 2	Not yet recruiting	December 2020	-
NCT02384382	Prostate Carcinoma Metastatic ... 展开 >>to the Bone Castration Resistant Prostate Cancer 收起 <<	Phase 2	Active, not recruiting	March 15, 2019	United States, Michigan ... 展开 >> Karmanos Cancer Institute Detroit, Michigan, United States, 48201 Karmanos Cancer Institute Weisberg Cancer Treatment Center Farmington Hills, Michigan, United States, 48334 United States, New Jersey Rutgers Cancer Institute of New Jersey New Brunswick, New Jersey, United States, 08903 United States, Wisconsin Lang Lab Madison, Wisconsin, United States, 53705 Wimr Pet/Ct Madison, Wisconsin, United States, 53705 Wimr Pet/Ct Madison, Wisconsin, United States, 53763 UW Clinical Sciences Center Madison, Wisconsin, United States, 53792 收起 <<
NCT02125084	Prostate Cancer	Phase 1	Active, not recruiting	January 2019	United States, Florida ... 展开 >> Florida Cancer Specialists Fort Myers, Florida, United States, 33916 Florida Cancer Center Saint Petersburg, Florida, United States, 33705 United States, Ohio Oncology Hematology Care Inc. Cincinnati, Ohio, United States, 45242 United States, Tennessee Tennessee Oncology Chattanooga, Tennessee, United States, 37404 Tennessee Oncology PLLC Nashville, Tennessee, United States, 37203 收起 <<
NCT02319837	Hormone Sensitive Prostate Can... 展开 >>cer Prostate Cancer Cancer of the Prostate 收起 <<	Phase 3	Active, not recruiting	July 31, 2023	-
NCT02003924	-		Active, not recruiting	-	-
NCT03336983	Prostate Cancer ... 展开 >> Bone Metastases 收起 <<	Phase 2	Recruiting	December 1, 2023	Italy ... 展开 >> Azienda Ospedaliera Spedali Civili di Brescia Recruiting Brescia, Italy, 25123 收起 <<
NCT02495974	-		Active, not recruiting	March 2019	-
NCT02138799	Drug-Drug Interaction (DDI) ... 展开 >> Healthy Subjects Pharmacokinetics of Enzalutamide 收起 <<	Phase 1	Completed	-	Germany ... 展开 >> Parexel International GmbH Berlin, Germany, 14050 收起 <<
NCT02116582	Metastatic Castration-Resistan... 展开 >>t Prostate Cancer 收起 <<	Phase 4	Completed	-	-
NCT02116582	-		Completed	-	-
NCT02028988	Intermediate Risk Prostate Can... 展开 >>cer 收起 <<	Phase 2	Active, not recruiting	June 2021	United States, Massachusetts ... 展开 >> Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02115 Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 收起 <<
NCT02528643	-		Active, not recruiting	-	-
NCT02528643	Advanced Hepatocellular Carcin... 展开 >>oma 收起 <<	Phase 2	Active, not recruiting	May 2019	-
NCT02207504	Castration-resistant Prostate ... 展开 >>Cancer 收起 <<	Phase 1	Active, not recruiting	December 2018	United States, Massachusetts ... 展开 >> Dana Farber Cancer Institute Boston, Massachusetts, United States, 02115 收起 <<
NCT02124668	Castration-Resistant Prostate ... 展开 >>Cancer Prostate Cancer 收起 <<	Phase 2	Completed	-	Georgia ... 展开 >> Site GE99503 Tbilisi, Georgia, 0144 Site GE99502 Tbilisi, Georgia, 0159 Russian Federation Site RU70002 Moscow, Russian Federation, 115478 Site RU70003 Moscow, Russian Federation, 125284 收起 <<
NCT02684227	Endometrial Cancer	Phase 2	Recruiting	August 2019	United States, Texas ... 展开 >> MD Anderson Cancer Center - Memorial City Regional Care Center Recruiting Houston, Texas, United States, 77024 Contact: Appointments 713-358-5300 Principal Investigator: Nicole Fleming, MD University of Texas MD Anderson Cancer Center Recruiting Houston, Texas, United States, 77030 Contact: MD Anderson Health Information Specialist 877-632-6789 The Woman's Hospital of Houston Recruiting Houston, Texas, United States, 77054 MD Anderson Cancer Center - Katy Regional Care Center Recruiting Houston, Texas, United States, 77094 Contact: Appointments 713-745-9940 Principal Investigator: Nicole Fleming, MD MD Anderson Cancer Center - Bay Area Regional Care Center Recruiting Nassau Bay, Texas, United States, 77058 Contact: Appointments 713-745-9940 Principal Investigator: Nicole Fleming, MD MD Anderson Cancer Center - Sugar Land Regional Care Center Recruiting Sugar Land, Texas, United States, 77478 Contact: Appointments 713-745-9940 Principal Investigator: Nicole Fleming, MD MD Anderson Cancer Center - The Woodlands Recruiting The Woodlands, Texas, United States, 77384 Contact: Appointments 713-745-9940 Principal Investigator: Nicole Fleming, MD 收起 <<
NCT01942837	Prostate Cancer	Phase 2	Active, not recruiting	August 2020	United States, Massachusetts ... 展开 >> Brigham and Women's Hospital Boston, Massachusetts, United States, 02115 Dana-Farber Cancer Institute Boston, Massachusetts, United States, 02115 Beth Israel Deaconess Medical Center Boston, Massachusetts, United States, 02215 South Shore Hospital Weymouth, Massachusetts, United States, 02190 United States, Washington University of Washington Medical Center/Seattle Cancer Care Alliance Seattle, Washington, United States, 98195 收起 <<
NCT03641560	Metastatic Castration Resistan... 展开 >>t Prostate Cancer 收起 <<	Phase 4	Recruiting	May 2020	India ... 展开 >> Site IN00002 Recruiting Ahmedabad, India Site IN00004 Recruiting Hubli, India Site IN00008 Recruiting Kolkata, India Site IN00003 Recruiting Nashik, India Site IN00007 Recruiting Nashik, India Site IN00001 Recruiting Pune, India 收起 <<
NCT02138162	Severe Hepatic Impairment ... 展开 >> Normal Hepatic Function 收起 <<	Phase 1	Completed	-	Bulgaria ... 展开 >> Comac Medical Ltd. Sofia, Bulgaria, 1612 收起 <<
NCT03103724	Carcinoma Prostate	Phase 2	Recruiting	March 16, 2019	Italy ... 展开 >> Elena Verzoni Recruiting Milan, Italy, 20133 Contact: Elena Verzoni, MD +390223904449 Elena.verzoni@istitutotumori.mi.it Contact: Rosanna Montone, Dr.ssa +390223903817 Rosanna.montone@istitutotumori.mi.it 收起 <<
NCT03196388	Prostate Carcinoma	Phase 2	Recruiting	December 2018	Spain ... 展开 >> Hospital Ramón y Cajal Recruiting Madrid, Spain Contact: Asuncion Hervas, MD 收起 <<
NCT03674814	Prostate Cancer	Phase 1	Recruiting	March 10, 2020	United States, Illinois ... 展开 >> University Of Chicago Medicine Comprehensive Cancer Center Recruiting Chicago, Illinois, United States, 60637 Contact: Julie Gruszczynski 773-834-9961 Jgruszczynski@medicine.bsd.uchicago.edu Principal Investigator: Russell Szmulewitz, MD 收起 <<
NCT01902251	Prostate Cancer ... 展开 >> Pharmacokinetics of Enzalutamide 收起 <<	Phase 1	Completed	-	United States, Colorado ... 展开 >> University of Colorado - Anschutz Medical Campus Denver, Colorado, United States, 80045 United States, Illinois University of Chicago Medical Center Chicago, Illinois, United States, 60637 United States, Pennsylvania University of Pittsburgh Medical Center Pittsburgh, Pennsylvania, United States, 15232 United States, Texas South Texas Accelerated Research Therapeutics San Antonio, Texas, United States, 78229 收起 <<
NCT02500901	Metastatic Prostate Cancer	Phase 1	Terminated(Suspended by funder... 展开 >>) 收起 <<	-	United States, Massachusetts ... 展开 >> Tufts Medical Center Boston, Massachusetts, United States, 02111 收起 <<
NCT03207529	Malignant Neoplasm of Breast	Phase 1	Not yet recruiting	January 2021	United States, Texas ... 展开 >> University of Texas MD Anderson Cancer Center Not yet recruiting Houston, Texas, United States, 77030 Contact: Clinical Research Operations mskaruturi@mdanderson.org 收起 <<
NCT03328364	-		Completed	-	Sweden ... 展开 >> Site SE46001 Malmo, Sweden 收起 <<
NCT03124615	Prostate Cancer	Phase 2	Recruiting	June 2021	Australia, New South Wales ... 展开 >> Macquarie University Recruiting North Ryde, New South Wales, Australia, 2109 Contact: Hung Tran +61 2 9812 3526 clinicaltrials@mq.edu.au Principal Investigator: Howard Gurney, MBBS 收起 <<
NCT02953860	Breast Cancer	Phase 2	Recruiting	November 2021	United States, Colorado ... 展开 >> University of Colorado Recruiting Aurora, Colorado, United States, 80045 Contact: Tiffany Colvin 303-848-0664 TIFFANY.COLVIN@UCDENVER.EDU Principal Investigator: Anthony D Elias, MD Lone Tree Medical Center Recruiting Lone Tree, Colorado, United States, 80124 Contact: Lisa Lopez lisa.lopez@ucdenver.edu Principal Investigator: Regina Brown, MD United States, Tennessee West Cancer Center Recruiting Germantown, Tennessee, United States, 38138 Contact: Julie Ryder 901-683-0055 jryder@westclinic.com Principal Investigator: Gregory Vidal, MD 收起 <<
NCT01927627	Adenocarcinoma of the Prostate	Phase 2	Active, not recruiting	March 2019	United States, Ohio ... 展开 >> Cleveland Clinic Taussig Cancer Institute, Case Comprehensive Cancer Center Cleveland, Ohio, United States, 44195 收起 <<
NCT02911467	Prostate Cancer	Phase 1	Recruiting	December 30, 2020	United States, California ... 展开 >> University of California, San Francisco Recruiting San Francisco, California, United States, 94158 Contact: Rahul Aggarwal, MD 415-353-9278 Rahul.Aggarwal@ucsf.edu Contact: Paula Dutton, BS 415-885-7871 Paula.Dutton@ucsf.edu 收起 <<
NCT02920229	68Ga-PSMA HBED-PET/CT ... 展开 >> Prostate Cancer 收起 <<	Not Applicable	Recruiting	November 2018	Italy ... 展开 >> Irst Irccs Recruiting Meldola, FC, Italy, 47014 Contact: Federica Matteucci, MD +390543739100 federica.matteucci@irst.emr.it Principal Investigator: Federica Matteucci, MD Sub-Investigator: Ugo De Giorgi, MD 收起 <<
NCT03170960	Urothelial Carcinoma ... 展开 >> Renal Cell Carcinoma Non-Small Cell Lung Cancer Castration-resistant Prostate Cancer Triple Negative Breast Cancer Ovarian Cancer Endometrial Cancer Hepatocellular Carcinoma Gastric Cancer Gastroesophageal Junction Adenocarcinoma Colorectal Cancer Head and Neck Cancer Differentiated Thyroid Cancer 收起 <<	Phase 1 Phase 2	Recruiting	December 2020	-
NCT02813226	Prostate Cancer	Not Applicable	Active, not recruiting	December 2020	Canada, Ontario ... 展开 >> Juravinski Hospital and Cancer Centre Hamilton, Ontario, Canada London Health Sciences Centre London, Ontario, Canada Sunnybrook-Odette Cancer Centre Toronto, Ontario, Canada 收起 <<
NCT03075735	-		Active, not recruiting	December 15, 2018	-
NCT02456571	-		Recruiting	June 2019	United States, North Carolina ... 展开 >> Duke University Medical Center Recruiting Durham, North Carolina, United States, 27710 Contact: Monika Anand, PhD 919-681-8838 monika.anand@duke.edu 收起 <<
NCT02008058	-		Active, not recruiting	December 2021	United States, Maryland ... 展开 >> Johns Hopkins University Baltimore, Maryland, United States, 21231 United States, North Carolina Lineberger Comprehensive Cancer Center Chapel Hill, North Carolina, United States, 27599 United States, Oregon Oregon Health and Science University Portland, Oregon, United States, 97239 United States, Washington University of Washington Seattle, Washington, United States, 98109 收起 <<
NCT02398526	-		Active, not recruiting	September 30, 2023	Germany ... 展开 >> Multiple Locations, Germany 收起 <<
NCT02729103	-		Completed	-	United States, New Jersey ... 展开 >> Whippany, New Jersey, United States 收起 <<
NCT02012920	Castration-resistant Prostate ... 展开 >>Cancer CRPC 收起 <<	Phase 2	Active, not recruiting	December 2018	-
NCT02202447	Prostate Cancer	Phase 1	Active, not recruiting	October 2018	United States, Arizona ... 展开 >> Scottsdale Healthcare Clinical Trials at the Virginia G. Piper Cancer Center Scottsdale, Arizona, United States, 85258 United States, Connecticut Yale Cancer Center New Haven, Connecticut, United States, 06520 United States, Louisiana Tulane Cancer Center New Orleans, Louisiana, United States, 70112 United States, Nevada Comprehensive Cancer Centers of Nevada Las Vegas, Nevada, United States, 89169 United States, New York Memorial Sloan Kettering Cancer Center New York, New York, United States, 10017 United States, Texas South Texas Accelerated Research Therapeutics San Antonio, Texas, United States, 78229 收起 <<
NCT02091531	Metastatic Castration-Resistan... 展开 >>t Prostate Cancer 收起 <<	Phase 2	Completed	-	United States, New York ... 展开 >> Memorial Sloan Kettering Cancer Center New York, New York, United States, 10065 收起 <<
NCT00268476	Prostate Cancer	Phase 2 Phase 3	Recruiting	September 2024	-
NCT03690141	Castrate-resistant Prostate Ca... 展开 >>ncer (CRPC) 收起 <<	Phase 2	Recruiting	April 2022	United States, Connecticut ... 展开 >> Yale Cancer Center Not yet recruiting New Haven, Connecticut, United States, 06510 Principal Investigator: Daniel Petrylak, M.D. United States, Illinois Northwestern University Not yet recruiting Chicago, Illinois, United States, 60611 Contact: Lela Lartey 312-695-1377 emanuela.lartey@northwestern.edu Principal Investigator: Maha Hussain, M.D. United States, Maryland Kimmel Center at Johns Hopkins Recruiting Baltimore, Maryland, United States, 21205 Contact: Rehab Abdallah 443-253-7021 rabdall1@jhmi.edu Principal Investigator: Michael Carducci, M.D. United States, Michigan Karmanos Cancer Institute Not yet recruiting Detroit, Michigan, United States, 48201 Principal Investigator: Elisabeth Heath, M.D. United States, Missouri Washington University Recruiting Saint Louis, Missouri, United States, 63110 Contact: Andrew Atkocius 314-747-1343 a.atkocius@wustl.edu Principal Investigator: Joel Picus, M.D. United States, Nevada Comprehensive Cancer Centers of Nevada Recruiting Las Vegas, Nevada, United States, 89169 Principal Investigator: Nicholas Vogelzang, M.D. United States, Ohio The Urology Group Recruiting Cincinnati, Ohio, United States, 45212 Contact: Bill Corbett 513-841-7555 wcorbett@urologygroup.com Principal Investigator: Marc Pliskin, M.D. United States, Pennsylvania Lancaster Urology Recruiting Lancaster, Pennsylvania, United States, 17604 Contact: Dawn Stern 717-431-2285 Dawns@lancuro.com Principal Investigator: Paul Sieber, M.D. United States, South Carolina Carolina Urologic Research Center Recruiting Myrtle Beach, South Carolina, United States, 29572 Contact: Laura Prince 843-839-1679 lprince@curcmb.com Principal Investigator: Neal Shore, M.D. United States, Washington University of Washington Not yet recruiting Seattle, Washington, United States, 89109 Principal Investigator: Celestia Higano, M.D. 收起 <<
NCT02494921	Prostate Cancer	Phase 1 Phase 2	Recruiting	December 2019	United States, California ... 展开 >> UCSF Helen Diller Family Comprehensive Cancer Center Active, not recruiting San Francisco, California, United States, 94115 United States, Illinois Northwestern University Recruiting Chicago, Illinois, United States, 60611 Contact: Benedito A. Carneiro, MD 312-472-1234 Principal Investigator: Benedito A. Carneiro, MD United States, Michigan University of Michigan Comprehensive Cancer Center Recruiting Ann Arbor, Michigan, United States, 48109 Contact: David Smith, MD 800-865-1125 Principal Investigator: David Smith, MD 收起 <<
NCT03763253	Prostate Cancer ... 展开 >> Metastatic Prostate Cancer 收起 <<	Phase 2	Not yet recruiting	March 1, 2024	United Kingdom ... 展开 >> Wirral University Teaching Hospital Not yet recruiting Birkenhead, United Kingdom, CH49 5PE Contact: Manal Kumar, MBBS MS MSh FRCS ED Principal Investigator: Manal Kumar, MBBS MS MSh FRCS ED Broomfield Hospital Not yet recruiting Chelmsford, United Kingdom, CM1 7ET Contact: Casey Rowan, FRCS (Urol) Principal Investigator: Casey Rowan, FRCS (Urol) Ashford and St Peters Not yet recruiting Chertsey, United Kingdom, KT16 0PZ Contact: Nimalan Arumainayagam, FRCS (Urol) Principal Investigator: Nimalan Arumainayagam, FRCS (Urol) Royal Devon and Exeter NHS Trust Not yet recruiting Exeter, United Kingdom, EX2 5DW Contact: John McGrath, BMedSci BMBS FRCS Principal Investigator: John McGrath, BMedSci BMBS FRCS Wycombe General Hospital Not yet recruiting High Wycombe, United Kingdom, HP11 2TT Contact: Neil Haldel, MBBS MB FRCS (Urol) Principal Investigator: Neil Haldel, MBBS MB FRCS (Urol) West Middlesex University Hospital Not yet recruiting Isleworth, United Kingdom, TW7 6AF Contact: Mathias Winkler, MBBS BSc MD FRCS (Urol) Principal Investigator: Mathias Winkler, MBBS BSc MD FRCS (Urol Cambridge Queen Elizabeth hospital, Kings Lynn Not yet recruiting King's Lynn, United Kingdom, PE30 4ET Contact: Gail Horan, MRCPI, FRCR Principal Investigator: Gail Horan, MRCPI, FRCR Guys and St Thomas Hospital Not yet recruiting London, United Kingdom, SE1 7EH Contact: Paul Cathcart, FRCS (Urol) Principal Investigator: Paul Cathcart, FRCS (Urol) St George's Hospital, St. George's University Hospitals NHS Foundation Trust Not yet recruiting London, United Kingdom, SW17 0QT Contact: Hasan Qazi, FRCS (Urol) Principal Investigator: Hasan Qazi, FRCS (Urol) Imperial College Healthcare NHS Trust Not yet recruiting London, United Kingdom, W6 8RF Contact: Hashim U Ahmed, BM, BCh (Oxon), BA, PhD, FRCS Principal Investigator: Hashim U Ahmed, BM, BCh (Oxon), BA, PhD, FRCS Sub-Investigator: Taimur T Shah, MBBS, BSc (Hons), MRCS Sub-Investigator: Martin J Connor, MBBS, BSc (Hons), MSc, MRCS Sub-Investigator: Mathias Winkler, MD, FRCS (Urol) Sub-Investigator: John Staffurth, MD, FRCP, FRCR Sub-Investigator: Alison Falconer, MA, MRCP, FRCR Sub-Investigator: Suraiya Dubash, MBBS, BSc, MRCP, FRCR London North West University Healthcare (Northwick Park) Not yet recruiting London, United Kingdom Contact: Giles Hellawell, MA BM BCH FRCS Principal Investigator: Giles Hellawell, MA BM BCH FRCS Newcastle Hospitals NHS trust (Freeman Hospital) Not yet recruiting Newcastle, United Kingdom, NE7 7DM Contact: Rakesh Heer, PhD FRCS(Urol) Principal Investigator: Rakesh Heer, PhD FRCS(Urol) Glan Clwyd Hospital (Betsi Cadwaladr University Health Board) Not yet recruiting Rhyl, United Kingdom, LL18 5UJ Contact: Kingsley Ekwueme, FRCS (Urol) Principal Investigator: Kingsley Ekwueme, FRCS (Urol) Southampton General Hospital Not yet recruiting Southampton, United Kingdom, SO16 6YD Contact: Tim Dudderidge, FRCS (Urol) Principal Investigator: Tim Dudderidge, FRCS (Urol) Lister Hospital Not yet recruiting Stevenage, United Kingdom, SG1 4AB Contact: Nikhil Vasdev, FRCS (Urol) Principal Investigator: Nikhil Vasdev, FRCS (Urol) Sunderland Royal hospital Not yet recruiting Sunderland, United Kingdom, SR4 7TP Contact: Stuart McCracken, FRCS (Urol) Principal Investigator: Stuart McCraken, FRCS (Urol) Wrexham Maelor Hospital (Betsi Cadwaladr University Health Board) Not yet recruiting Wrexham, United Kingdom, LL13 7TD Contact: Iqbal Shergill, FRCS (Urol) Principal Investigator: Iqbal Shergill, FRCS (Urol) 收起 <<
NCT02432001	-		Recruiting	December 2018	United States, California ... 展开 >> University of California, Davis Recruiting Davis, California, United States, 95616 Contact: Primo Lara, MD University of California, Los Angeles Recruiting Los Angeles, California, United States, 90095 Contact: Matthew Rettig, MD UCSF Helen Diller Family Comprehensive Cancer Center Recruiting San Francisco, California, United States, 94115 Contact: Paula Dutton 415-885-7871 Paula.Dutton@ucsf.edu United States, Oregon Oregon Health & Science University Recruiting Portland, Oregon, United States, 97239 Contact: Tomasz Beer, MD Canada University of British Columbia Recruiting Vancouver, Canada Contact: Kim Chi, MD 收起 <<
NCT03551782	Castration-Resistant Prostatic... 展开 >> Neoplasms 收起 <<	Phase 1	Recruiting	January 29, 2021	-
NCT02606123	Prostatic Neoplasms ... 展开 >> Genital Neoplasms, Male Genital Diseases, Male Prostatic Diseases 收起 <<	Phase 1 Phase 2	Terminated(At end of Phase 1 e... 展开 >>xcessive high pill burden (18 capsules/day)) 收起 <<	-	United States, Arizona ... 展开 >> Scottsdale Healthcare Hospitals DBA HonorHealth Scottsdale, Arizona, United States, 85258 United States, Michigan University of Michigan Health System Ann Arbor, Michigan, United States, 48109 Karmanos Cancer Institute Detroit, Michigan, United States, 48201 United States, Washington Seattle Cancer Care Alliance Seattle, Washington, United States, 98109 Canada, British Columbia British Columbia Cancer Agency - Vancouver Centre Vancouver, British Columbia, Canada, V5Z 4E6 收起 <<
NCT03685591	Hormone Receptor Positive Adva... 展开 >>nced Breast Cancer Metastatic Breast Cancer Human Epidermal Receptor 2 Negative Advanced Breast Cancer Castration Resistant Prostate Cancer 收起 <<	Phase 1	Recruiting	August 24, 2023	United States, Texas ... 展开 >> The University of Texas MD Anderson Cancer Center Not yet recruiting Houston, Texas, United States, 77030-4009 The University of Texas - MD Anderson Cancer Center Not yet recruiting Houston, Texas, United States, 77030 NEXT Oncology Recruiting San Antonio, Texas, United States, 78240 收起 <<
NCT02826772	Metastatic Castrate Resistant ... 展开 >>Prostate Cancer (mCRPC) 收起 <<	Phase 1 Phase 2	Recruiting	December 2018	United States, Maryland ... 展开 >> Chesapeake Urology Research Associates Recruiting Towson, Maryland, United States, 21204 Contact: Heather Thomas, CCRC 443-471-5742 hthomas@cua.md Contact: Heidi Miller, BScN 514.463.8837 hmiller@accelovance.com Principal Investigator: Richard Levin, MD United States, Nebraska G U Research Network Recruiting Omaha, Nebraska, United States, 68130 Contact: Tony Romero, MS, CCRC 402-697-2229 tromero@gucancer.com Contact: Heidi Miller, BScN 514.463.8837 hmiller@accelovance.com Principal Investigator: Luke T Nordquist, MD United States, Nevada Comprehensive Cancer Centers of Nevada Recruiting Las Vegas, Nevada, United States, 89169 Contact: Khin Win, MBA, MBBS 702-952-3834 khin.win@usoncology.com Contact: Heidi Miller, BScN 514.463.8837 hmiller@accelovance.com Principal Investigator: Nicholas Vogelzang, MD United States, New Jersey Rutgers University Recruiting New Brunswick, New Jersey, United States, 08901 Contact: Tracie Saunders, RN, MS, OCN, CCRC 732-235-8861 tracie.saunders@cinj.rutgers.edu Contact: Heidi Miller, BScN 514.463.8837 hmiller@accelovance.com Principal Investigator: Mark N Stein, MD United States, New York North Shore Hematology Oncology Associates Recruiting East Setauket, New York, United States, 11733 Contact: Don Marx, MBA, MS, RT 631-675-5143 dmarx@nycancer.com Contact: Heidi Miller, BScN 514.463.8837 hmiller@accelovance.com Principal Investigator: Jeffrey L Vacirca, MD, FACP United States, Ohio Gabrail Cancer Center Research Recruiting Canton, Ohio, United States, 44718 Contact: Carrie Smith, RN 484-998-8315 csmith@gabrailcancercenter.com Contact: Heidi Miller, BScN 514.463.8837 hmiller@accelovance.com Principal Investigator: Nashat Gabrail, MD 收起 <<
NCT03526562	Prostatic Neoplasms ... 展开 >> Exercise Castration-resistant Prostate Cancer Physical Activity 收起 <<	Not Applicable	Recruiting	October 2018	Belgium ... 展开 >> University Hospital ghent Recruiting Ghent, Oost-Vlaanderen, Belgium, 9000 Contact: Renée Bultijnck, Msc 932 3320342 renee.bultijnck@ugent.be Contact: Piet Ost, MD, PhD 收起 <<
NCT02856100	-		Unknown	December 2018	United States, Maryland ... 展开 >> Johns Hopkins University Recruiting Baltimore, Maryland, United States, 21287 Contact: Ghedem Solomon, MS 410-614-2789 gsolomo6@jhmi.edu Contact: Akimosa Jeffrey-Kwanisai, MBA 410-502-1040 ajeffre2@jhmi.edu 收起 <<
NCT03356912	Prostate Cancer ... 展开 >> Castration-resistant Prostate Cancer 收起 <<	Phase 2	Enrolling by invitation	May 4, 2021	Italy ... 展开 >> University Federico II of Naples Naples, Italy 收起 <<
NCT03514836	Castration-resistant Prostate ... 展开 >>Cancer 收起 <<	Phase 1 Phase 2	Recruiting	April 2021	Czechia ... 展开 >> Fakultní nemocnice v Motole Recruiting Praha, Czechia, 150 06 收起 <<
NCT03050866	Circulating Tumor Cell ... 展开 >> Metastatic Prostate Cancer 收起 <<	Phase 2	Recruiting	February 2020	Netherlands ... 展开 >> Reinier de Graaf Groep Recruiting Delft, Netherlands Contact: A.C.M. Van de Luijtgaarden, MD Principal Investigator: A.C.M. Van de Luijtgaarden, MD Medisch Centrum Haaglanden Recruiting Den Haag, Netherlands Contact: H. Helgason, MD Principal Investigator: H Helgason, MD Groene Hart Ziekenhuis Recruiting Gouda, Netherlands Contact: W. Van der Deure, MD Principal Investigator: W Van der Deure, MD Canisius Wilhelmina Ziekenhuis Recruiting Nijmegen, Netherlands Contact: R. Somford, MD Principal Investigator: R. Somford, MD Erasmus MC Recruiting Rotterdam, Netherlands Contact: Bodine Belderbos caba.v7@erasmusmc.nl Franciscus Gasthuis en Vlietland Recruiting Rotterdam, Netherlands Contact: Paul Hamberg Maasstad Ziekenhuis Recruiting Rotterdam, Netherlands Contact: B. Haberkorn, MD Principal Investigator: B. Haberkorn, MD Tweesteden Ziekenhuid Recruiting Tilburg, Netherlands Contact: A. Coumou, MD Principal Investigator: A Coumou, MD Admiraal de Ruyter Ziekenhuis Recruiting Vlissingen, Netherlands Contact: H.K. Van Halteren, MD Principal Investigator: H.K. Van Halteren, MD 收起 <<
NCT01695044	Prostate Cancer	Phase 2	Completed	-	-
NCT01695044	-		Completed	-	-
NCT03725761	Prostate Cancer	Phase 2	Recruiting	June 1, 2021	United States, California ... 展开 >> UCSD Moores Cancer Center Not yet recruiting La Jolla, California, United States, 92093 Contact: Candance Winkler 858-822-5398 cmwinkler@ucsd.edu Principal Investigator: Rana McKay, MD United States, Michigan Wayne State University Barbara Ann Karmanos Cancer Institute Not yet recruiting Detroit, Michigan, United States, 48201 Contact: Brenda Dickow 313-576-9372 dickowb@karmanos.org Principal Investigator: Elisabeth Heath, MD United States, Minnesota University of Minnesota Masonic Cancer Center Not yet recruiting Minneapolis, Minnesota, United States, 55455 Contact: Shilpa Gupta 612-625-0571 guptash@umn.edu Principal Investigator: Arpit Rao, MD United States, New York Memorial Sloan-Kettering Cancer Center Not yet recruiting New York, New York, United States, 10065 Contact: Rebecca Green 646-888-1313 borsukr@mskcc.org Principal Investigator: Susan Slovin, MD Weill Cornell Medical College Not yet recruiting New York, New York, United States, 10065 Contact: Jyoti Sreekumar 646-962-9340 jys2004@med.cornell.edu Principal Investigator: Himisha Beltran, MD United States, Wisconsin University of Wisconsin Carbone Cancer Center Recruiting Madison, Wisconsin, United States, 53792 Contact: Mary Jane Staab 608-263-7107 mjs@medicine.wisc.edu Principal Investigator: Christos Kyriakopoulos 收起 <<
NCT02621190	Prostatic Neoplasms	Phase 2	Withdrawn(no approval)	June 2019	Netherlands ... 展开 >> Erasmus MC Cancer Institute Rotterdam, Netherlands, 3075 EA 收起 <<
NCT02512185	-		Recruiting	February 2019	Canada, Ontario ... 展开 >> Juravinski Cancer Centre Recruiting Hamilton, Ontario, Canada, L8V 5C2 Contact: Sebastien Hotte, MD 905-387- 9711 ext 64605 sebastien.hotte@jcc.hhsc.ca Kingston Health Sciences Centre -KGH Recruiting Kingston, Ontario, Canada, K7L 2V7 Contact: Carrie Lindsay : 613-549-6666 ext 7231 Carrie.Lindsay@kingstonhsc.ca Principal Investigator: Richard Gregg, MD., FRCPC Odette Cancer Centre Recruiting Toronto, Ontario, Canada, M4N 3M5 Contact: Urban Emmenegger, MD 416-480-4928 urban.emmenegger@sunnybrook.ca Sub-Investigator: Scott Berry, MD Princess Margaret Cancer Centre Recruiting Toronto, Ontario, Canada, M5G 2M9 Contact: Henriette Breunis +1-416-946-4501 ext 3926 hbreunis@uhnresearch.ca Principal Investigator: Shabbir Alibhai, MD Sub-Investigator: Anthony Joshua, MD Sub-Investigator: Aaron Hansen, MD 收起 <<
NCT02907372	Metastatic Castration-resistan... 展开 >>t Prostate Cancer (CRPCa) 收起 <<	Not Applicable	Recruiting	November 2020	France ... 展开 >> CHU Recruiting Amiens, France Contact: Mathieu BOONE, MD Principal Investigator: Mathieu BOONE centre François Baclesse Recruiting Caen, France Contact: Florence JOLY, PhD Principal Investigator: Florence JOLY, PhD Institut régional du Cancer de Montpellier (ICM) Recruiting Montpellier, France Contact: Amélie DARLIX, MD Principal Investigator: Amélie DARLIX, MD Chu Rouen Recruiting Rouen, France Contact: Sophie GOUERANT, MD Principal Investigator: Sophie GOUERANT, MD CHU Not yet recruiting Strasbourg, France Contact: Philippe BARTHELEMY, MD Principal Investigator: Philippe BARTHELEMY, MD IGR Not yet recruiting Villejuif, France Contact: Giulia BACIARELLO, PhD Principal Investigator: Karim FIZAZI, PhD 收起 <<
NCT02903160	Prostate Cancer	Phase 2	Recruiting	October 2019	United States, New York ... 展开 >> Mount Sinai Beth Israel Recruiting New York, New York, United States, 10011 Contact: Bobby Liaw, MD 212-604-6010 bobby.liaw@mountsinai.org Principal Investigator: Bobby Liaw, MD Mount Sinai West Withdrawn New York, New York, United States, 10019 Icahn School of Medicine at Mount Sinai Recruiting New York, New York, United States, 10028 Contact: William Oh, MD 212-659-5549 william.oh@mssm.edu Principal Investigator: William Oh, MD 收起 <<
NCT03236688	-		Recruiting	September 2018	United States, Connecticut ... 展开 >> Yale University School of Medicine Recruiting New Haven, Connecticut, United States, 06520 Contact: Ken F Blount, Ph.D. 203-785-5927 ken.blount@yale.edu Principal Investigator: Daniel Petrylak, MD 收起 <<

靶点	Androgen Receptor Androgen Receptor, IC50:36 nM
描述	The androgen receptor (AR), also known as NR3C4, is one kind of nuclear receptor. When binding either of androgenic hormones, testosterone or dihydrotestosterone, androgen receptor can be activated and translocate into the nucleus. Increased androgen receptor gene expression may critically influence cancer progression such as, prostate cancer^[1]. Enzalutamide, also called as MDV3100, is an androgen-receptor (AR) antagonist with IC50 of 36 nM (measured by relative AR binding affinity)^[1]. Enzalutamide can prevent nuclear translocation and impair DNA binding of AR induced by R1881 (a synthetic androgen)^[1], which facilitated mediating reduced PSA levels in AR-positive prostate cancer cell line (LNCaP) and inhibiting the growth of LNCaP cells^[3]. Enzalutamide is the first approved second-generation androgen receptor (AR) antagonist in the treatment of metastatic castration-resistant prostate cancer (mCRPC) and shows good pharmacokinetic profiles in human^[4] as well as animal^[5].
作用机制	Enzalutamide is a competitive inhibitor of AR ligand binding.^[6]

Dose	Mice: min = 10 mg/kg^[7], max = 60 mg/kg^[8]
Administration	p.o.

CAS号	915087-33-1
分子式	C₂₁H₁₆F₄N₄O₂S
分子量	464.436

别名	MDV3100
运输	蓝冰

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