Megestrol acetate

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Chemical Structure| 595-33-5 同义名 : 宜利治 ;Megestryl Acetate;BDH1298;Niagestin.;Megestil;Pallace. Maygace;Ovaban;Megace;NSC 71423;SC10363
CAS号 : 595-33-5
货号 : A561132
分子式 : C24H32O4
纯度 : 98%
分子量 : 384.509
MDL号 : MFCD00056470
存储条件：

Pure form Sealed in dry,Room Temperature

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(46.81 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Megestrol acetate was one of the first progestational agents to be evaluated for use in the hormonal therapy of advanced breast cancer. As single-agent therapy, the average overall response rate to megestrol acetate therapy is 30%[3]. Megestrol acetate doses equal to or lower than 240 mg/day lead to slight weight gain in patients with cancer-associated cachexia[4]. The mechanism of action of megestrol is believed to involve stimulation of appetite by both direct and indirect pathways and antagonism of the metabolic effects of the principal catabolic cytokines[5]. The risk of megestrol-induced Cushing syndrome, especially with high doses of the medication, should be considered as a possible adverse effect in patents with renal insufficiency[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.60mL

0.52mL

0.26mL

13.00mL

2.60mL

1.30mL

26.01mL

5.20mL

2.60mL
参考文献

[1]Sung JH, An HS, et al. Megestrol Acetate Increases the Proliferation, Migration, and Adipogenic Differentiation of Adipose-Derived Stem Cells via Glucocorticoid Receptor. Stem Cells Transl Med. 2015 Jul;4(7):789-99.

[2]Kelicen Ugur P, Lule S, et al. Megestrol acetate inhibits the expression of cytoplasmic aromatase through nuclear C/EBPβ in reperfusion injury-induced ischemic rat hippocampus. Eur J Pharmacol. 2011 Mar 11;654(3):217-25.

[3]Sedlacek SM. An overview of megestrol acetate for the treatment of advanced breast cancer. Semin Oncol. 1988 Apr;15(2 Suppl 1):3-13.

[4]Ruiz-García V, Juan O, Pérez Hoyos S, Peiró R, Ramón N, Rosero MA, García MA. Acetato de megestrol: una revisión sistemática de su utilidad clínica para la ganancia de peso en los enfermos con neoplasia y caquexia [Megestrol acetate: a systematic review usefulness about the weight gain in neoplastic patients with cachexia]. Med Clin (Barc). 2002 Jul 6;119(5):166-70. Spanish

[5]Femia RA, Goyette RE. The science of megestrol acetate delivery: potential to improve outcomes in cachexia. BioDrugs. 2005;19(3):179-87

[6]Caparrós GC, Zambrana JL, Delgado-Fernandez M, Díez F. Megestrol-induced Cushing syndrome. Ann Pharmacother. 2001 Oct;35(10):1208-10