A single intraperitoneal injection of MS48107 at a dose of 25 mg/kg results in substantial exposure levels (exceeding 10 μM) in both plasma and brain within 0.5 hours in Swiss Albino mice. These elevated levels persist in both plasma and brain for a duration of 2 hours ^[1].

5-HT2B exhibits moderate binding affinity for MS48107, characterized by a Ki value of 219 nM. While MS48107 demonstrates no agonist activity at 5-HT2B receptors, it manifests weak antagonist activity with a Ki value of 310 nM^[1].

MS48107 exhibits agonist activity exclusively at the MT1 and MT2 receptors. Specifically, it functions as a weak full agonist at the MT1 receptor (EC50 = 320 nM) and as a weak partial agonist at the MT2 receptor (EC50 = 540 nM). Furthermore, MS48107 demonstrates low binding affinities for both MT1 (5900 nM) and MT2 (1100 nM) receptors ^[1].