There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
MRS 2578 is a selective and potent antagonist of the P2Y6 receptor, demonstrating IC50 values of 37 nM in humans and 98 nM in rats. It shows negligible activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors[1][2].
体内研究
MRS 2578 (3 mg/kg; i.p.; for 3 days) significantly reduces collagen deposition induced by pressure overload without impacting cardiomyocyte hypertrophy following transverse aortic constriction (TAC)[4].
体外研究
MRS 2578 at 1 μM entirely inhibits the protective effect of UDP against TNFα-induced apoptosis in 1321N1 astrocytoma cells[1].
MRS 2578 at 10 μM completely eliminates TNF-α induced NF-κB reporter activity in HMEC-1 cells. Additionally, MRS 2578 significantly diminishes TNF-α–induced proinflammatory gene expression in these cells at the same concentration[2].
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