MRS 2578

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Chemical Structure| 711019-86-2 同义名 : -
CAS号 : 711019-86-2
货号 : A807950
分子式 : C20H20N6S4
纯度 : 98%
分子量 : 472.673
MDL号 : MFCD07370141
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(105.78 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • P2Y receptor

    P2Y6, IC50:37 nM
描述 MRS 2578 is a selective and potent antagonist of the P2Y6 receptor, demonstrating IC50 values of 37 nM in humans and 98 nM in rats. It shows negligible activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.12mL

0.42mL

0.21mL

10.58mL

2.12mL

1.06mL

21.16mL

4.23mL

2.12mL
参考文献

[1]Mamedova LK, et al. Diisothiocyanate derivatives as potent, insurmountable antagonists of P2Y6 nucleotide receptors. Biochem Pharmacol, 2004, 67(9), 1763-1770.

[2]Nishida M, et al. P2Y6 receptor-Galpha12/13 signalling in cardiomyocytes triggers pressure overload-induced cardiacfibrosis. EMBO J. 2008 Dec 3;27(23):3104-15.

[3]Vieira RP, et al. Purinergic receptor type 6 contributes to airway inflammation and remodeling in experimental allergic airway inflammation. Am J Respir Crit Care Med, 2011, 184(2), 215-223.