规格 | 价格 | 会员价 | 库存 | 数量 | |||
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{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]} |
{[ getRatePrice(item.pr_rmb, 1,1) ]} | {[ getRatePrice(item.pr_rmb_sale, 1,1) ]} {[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]} {[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]} | 现货 | 咨询 | - + |
快速发货 顺丰冷链运输,1-2 天到达
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免费溶解
产品名称 | Adenosine Receptor ↓ ↑ | 其他靶点 | 纯度 | ||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
ZM241385 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Istradefylline |
+++
Adenosine A2A receptor, Ki: 2.2 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Reversine |
+
human A3 adenosine receptor, Ki: 0.66 μM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
SCH58261 |
++++
bovine A2a, Ki: 2.0 nM rat A2a, Ki: 2.3 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
A2A receptor antagonist 1 |
++
A1R, Ki: 264 nM A2AR, Ki: 4 nM |
{[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | The A2B adenosine receptor (AR) is a member of the P1 family of seven-transmembrane ARs, and it couples to Gs to increase cAMP and Gq11 to increase (1,4,5)inositol triphosphate (IP3)/diacylglycerol (DAG). MRS 1754 is a selective antagonist ligand of A2BAR with Ki value of 1.97 nM[1]. 3H-MRS 1754 was shown to bind with high affinity to a single class of binding sites in membranes of HEK-293 cells expressing the human A2B receptor[2]. Finally, MRS 1754 inhibited the NECA-induced Ca2+ responses and cAMP production in a concentration-dependent manner. Treatment of the T24 cell line for 4h with NECA resulted in an increase in interleukin-8 production which was sensitive to the adenosine A2B antagonist MRS 1754[3]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.06mL 0.41mL 0.21mL |
10.28mL 2.06mL 1.03mL |
20.55mL 4.11mL 2.06mL |
CAS号 | 264622-58-4 |
分子式 | C26H26N6O4 |
分子量 | 486.522 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 14 mg/mL(28.78 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |