MOZ-IN-2 | Histone Acetyltransferase Inhibitor | AmBeed-信号通路专用抑制剂

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MOZ-IN-2 {[allProObj[0].p_purity_real_show]}

货号：A983022

MOZ-IN-2是一种 MOZ 抑制剂，IC50 为 125 μM。

MOZ-IN-2 化学结构
CAS号：2055397-88-9

MOZ-IN-2 3D分子结构
CAS号：2055397-88-9

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MOZ-IN-2 纯度/质量文件产品仅供科研

货号：A983022 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]; • Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]; • Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]; 更多 >

MOZ-IN-2 生物活性

描述

Histone acetyltransferase 1 (HAT1) is a type B histone acetyltransferase, regulating the acetylation of both histone and non-histone proteins. HAT1 modulates lysine succinylation on various proteins including histones and non-histones. HAT1 succinylates histone H3 on K122, contributing to epigenetic regulation and gene expression in cancer cells^[1].HAT1 is responsible for the cytosolic diacetylation of newly synthesized histone H4 on lysines 5 and 12, which accompanies replication-coupled chromatin assembly^[2]. MOZ (monocytic leukaemia zinc finger protein; also known as ZNF220 or MYST3) is a member of the MYST family of protein acetyltransferases^[3]. MOZ is one of the most important histone acetyltransferases (HATs) that has an effective role in gene expression. It is an important partner in chromosomal rearrangement that usually occurs in hematological malignancies such as leukemia^[4]. It functions as a quaternary complex with the bromodomain PHD finger protein 1 (BRPF1), the human Esa1-associated factor 6 homolog (hEAF6), and the inhibitor of growth 5 (ING5)^[5]. MOZ-TIF2 silences expression of the CDKN2A locus (p16(INK4a) and p19(ARF)), inhibits the triggering of senescence and enhances proliferation, providing conditions favorable to the development of leukemia^[6]. MOZ-IN-2 is an protein MOZ inhibitor(IC50 of 125 μM)^[7].

MOZ-IN-2 参考文献

[1]Guang Yang,et al. Histone acetyltransferase 1 is a succinyltransferase for histones and non-histones and promotes tumorigenesis. EMBO Rep. 2021 Feb 3;22(2):e50967.

[2]Paula A Agudelo Garcia,et al. Histone acetyltransferase 1 is required for DNA replication fork function and stability. J Biol Chem. 2020 Jun 19;295(25):8363-8373.

[3]Philip J F Troke,et al. MOZ fusion proteins in acute myeloid leukaemia. Biochem Soc Symp. 2006;(73):23-39.

[4]Kiyanoush Mohammadi,et al. Investigation of the changes in the expression levels of MOZ gene in colorectal cancer tissues. J Gastrointest Oncol. 2019 Feb;10(1):68-73.

[5] Samuel Carlson,et al. The MOZ histone acetyltransferase in epigenetic signaling and disease. J Cell Physiol. 2014 Nov;229(11):1571-4.

[6]Anne Largeot,et al. Expression of the MOZ-TIF2 oncoprotein in mice represses senescence. Exp Hematol. 2016 Apr;44(4):231-7.e4.

[7]RYL SULFONOHYDRAZIDES. WO2016198507 A1.

MOZ-IN-2 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.43mL

2.69mL

1.34mL

26.85mL

5.37mL

2.69mL

MOZ-IN-2 技术信息

CAS号	2055397-88-9
分子式	C₁₇H₁₃FN₄O₃S
分子量	372.373

别名
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Room Temperature

溶解度

DMSO: 105 mg/mL(281.97 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验配方

摩尔计算器

计算溶液所需的质量，体积或浓度。 Ambeed 摩尔浓度计算器基于以下方程式：

浓度 (mol/L) × 体积 (L) × 分子量 (g/mol)=质量 (g)

浓度

体积

分子量

质量

MOZ-IN-2 {[allProObj[0].p_purity_real_show]}

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MOZ-IN-2 生物活性

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MOZ-IN-2 实验方案

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MOZ-IN-2 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

MOZ-IN-2 质控信息

MOZ-IN-2 生物活性

MOZ-IN-2 参考文献

MOZ-IN-2 实验方案

MOZ-IN-2 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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MOZ-IN-2 纯度/质量文件产品仅供科研