ML-792
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货号：A235283
ML-792是一种在酶活检测中对SAE/SUMO 1和SAE/SUMO 2具有强效和选择性抑制作用的抑制剂，IC50 分别为3 nM和11 nM。它对NAE /NEDD8和UAE/泛素的抑制效果要小得多，IC50 值分别超过32 μM和100 μM。
ML-792 化学结构
ML-792 3D分子结构
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ML-792 纯度/质量文件 产品仅供科研
货号：A235283
标准纯度：
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产品说明书
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ML-792 质控信息
ML-792 生物活性
描述
Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-translational modification in diverse biological signals in the cell, including DNA repair, nuclear transport, gene expression and so on. SUMO activating enzyme E (SAE) catalyzes the condensation between the SUMO C-terminal carboxylate and ATP to form a SUMO–AMP conjugate that subsequently reacts with the catalytic Cys residue of SAE to form a SUMO~SAE thioester conjugate[2] [3]
ML-792 参考文献
[1] He X, Riceberg J, et al. Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor. Nat Chem Biol. 2017 Sep 11.
[2] Zhao B, Villhauer EB, Bhuripanyo K, Kiyokawa H, Schindelin H, Yin J. SUMO-mimicking peptides inhibiting protein SUMOylation. Chembiochem. 2014 Dec 15;15(18):2662-6. doi: 10.1002/cbic.201402472. Epub 2014 Nov 20. PMID: 25412743; PMCID: PMC4643655.
[3] He X, Riceberg J, Soucy T, Koenig E, Minissale J, Gallery M, Bernard H, Yang X, Liao H, Rabino C, Shah P, Xega K, Yan ZH, Sintchak M, Bradley J, Xu H, Duffey M, England D, Mizutani H, Hu Z, Guo J, Chau R, Dick LR, Brownell JE, Newcomb J, Langston S, Lightcap ES, Bence N, Pulukuri SM. Probing the roles of SUMOylation in cancer cell biology by using a selective SAE inhibitor. Nat Chem Biol. 2017 Nov;13(11):1164-1171. doi: 10.1038/nchembio.2463. Epub 2017 Sep 11. PMID: 28892090.
ML-792 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.81mL
0.36mL
0.18mL
9.07mL
1.81mL
0.91mL
18.14mL
3.63mL
1.81mL
ML-792 技术信息
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