产品说明书
ML-792
 |
同义名 : | - |
| CAS号 : | 1644342-14-2 | |
| 货号 : | A235283 | |
| 分子式 : | C21H23BrN6O5S | |
| 纯度 : | 99%+ | |
| 分子量 : | 551.413 | |
| MDL号 : | MFCD32174257 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(190.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Small ubiquitin-like modifier (SUMO) family proteins regulate target-protein functions by post-translational modification in diverse biological signals in the cell, including DNA repair, nuclear transport, gene expression and so on. SUMO activating enzyme E (SAE) catalyzes the condensation between the SUMO C-terminal carboxylate and ATP to form a SUMO–AMP conjugate that subsequently reacts with the catalytic Cys residue of SAE to form a SUMO~SAE thioester conjugate[2]. ML-792 is a SAE inhibitor that potently and selectively blocks SAE enzyme activity and total SUMOylation, thus decreasing cancer cell proliferation[3]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.81mL 0.36mL 0.18mL |
9.07mL 1.81mL 0.91mL |
18.14mL 3.63mL 1.81mL |
| 参考文献 |
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