MK-571 钠盐 /MK-571 sodium
{[allProObj[0].p_purity_real_show]}
货号：A407864
同义名：
L-660711 sodium;MK-571 Sodium salt
MK-571 sodium 是一种竞争性、强效且选择性的 LTD4 拮抗剂，Ki 值为 0.22 nM。
MK-571 sodium 化学结构
MK-571 sodium 3D分子结构
规格
价格
会员价
库存
数量
{[ item.pr_size ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]}
{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}
{[ suihuo_tips(item.pr_tag_price) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]}
{[ getRatePrice(item.pr_rmb,item.pr_rate,1) ]}
{[ suihuo_tips(item.pr_tag_price) ]}
{[ getRatePrice(item.pr_rmb, 1,1) ]}{[ suihuo_tips(item.pr_tag_price) ]}
{[ getRatePrice(item.pr_rmb_sale, 1,1) ]}
{[ getRatePrice(item.pr_rmb,item.pr_rate,item.mem_rate) ]}
{[ getRatePrice(item.pr_rmb,1,item.mem_rate) ]}
现货
咨询
-
+
MK-571 sodium 纯度/质量文件 产品仅供科研
货号：A407864
标准纯度：
{[allProObj[0].p_purity_real_show]}
产品说明书
全球学术期刊中引用的产品
• JMC , 2024. Ambeed. A918471 ,
A995972
]
• Anal. Chem. , 2024, 96(50): 19947-19954. Ambeed. A261947 ,
A1165388
]
• ACS Biomater. Sci. Eng. , 2024. Ambeed. A220462
]
• ACS Biomater. Sci. Eng. , 2024. Ambeed. A165235 ,
A110205
]
• Pharmaceutics , 2024, 16(12): 1546. Ambeed. A272538 ,
A187261 ,
A691302 ,
A506702
]
更多 >
MK-571 sodium 质控信息
MK-571 sodium 生物活性
描述
Leukotrienes (LT) C4, D4s and E4 are thought to play a fundamental role in lung pathophysislogy. MK-571 Sodium is a potent and selective LTD4 receptor antagonist with K i values of 0.22 nM and 2.1 nM in guinea pig and human lung membranes, respectively[6] [7] [8]
MK-571 sodium 动物研究
Dose
Guinea pig: 2 mg/kg[3] [4] [5]
Administration
i.v., i.p.
MK-571 sodium 参考文献
[1] Tivnan A, Zakaria Z, et al. Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 2015 Jun 16;9:218.
[2] Jones TR, Zamboni R, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28.
[3] Yang XX, Powell WS, et al. Hyperpnea-induced bronchoconstriction is dependent on tachykinin-induced cysteinyl leukotriene synthesis. J Appl Physiol (1985). 1997 Feb;82(2):538-44.
[4] Kanwar S, Johnston B, et al. Leukotriene C4/D4 induces P-selectin and sialyl Lewis(x)-dependent alterations in leukocyte kinetics in vivo. Circ Res. 1995 Nov;77(5):879-87.
[5] Kilic E, Spudich A, et al. ABCC1: a gateway for pharmacological compounds to the ischaemic brain. Brain. 2008 Oct;131(Pt 10):2679-89.
[6] Jones TR, Zamboni R, Belley M, Champion E, Charette L, Ford-Hutchinson AW, Frenette R, Gauthier JY, Leger S, Masson P, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28. doi: 10.1139/y89-004. PMID: 2540892.
[7] Tivnan A, Zakaria Z, O'Leary C, Kögel D, Pokorny JL, Sarkaria JN, Prehn JH. Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 2015 Jun 16;9:218. doi: 10.3389/fnins.2015.00218. PMID: 26136652; PMCID: PMC4468867.
[8] Barrington RD, Needs PW, Williamson G, Kroon PA. MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux. Biochem Pharmacol. 2015 Jun 1;95(3):193-200. doi: 10.1016/j.bcp.2015.03.005. Epub 2015 Mar 20. PMID: 25801004; PMCID: PMC4428793.
展开
MK-571 sodium 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
1.86mL
0.37mL
0.19mL
9.31mL
1.86mL
0.93mL
18.62mL
3.72mL
1.86mL
MK-571 sodium 技术信息
搜索
