MK-571 钠盐 /MK-571 sodium
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货号：A407864
同义名：
L-660711 sodium;MK-571 Sodium salt
MK-571 Sodium is a competitive, potent and selective LTD4 antagonist with Ki values of 0.22 nM.
MK-571 sodium 化学结构
MK-571 sodium 3D分子结构
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MK-571 sodium 质控信息
Montelukast Sodium
✔
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MK571
✔
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Zafirlukast
✔
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1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。
MK-571 sodium 生物活性
描述
Leukotrienes (LT) C4, D4s and E4 are thought to play a fundamental role in lung pathophysislogy. MK-571 Sodium is a potent and selective LTD4 receptor antagonist with K i values of 0.22 nM and 2.1 nM in guinea pig and human lung membranes, respectively[6] [7] [8]
MK-571 sodium 动物研究
Dose
Guinea pig: 2 mg/kg[3] [4] [5]
Administration
i.v., i.p.
MK-571 sodium 参考文献
[1] Tivnan A, Zakaria Z, et al. Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 2015 Jun 16;9:218.
[2] Jones TR, Zamboni R, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28.
[3] Yang XX, Powell WS, et al. Hyperpnea-induced bronchoconstriction is dependent on tachykinin-induced cysteinyl leukotriene synthesis. J Appl Physiol (1985). 1997 Feb;82(2):538-44.
[4] Kanwar S, Johnston B, et al. Leukotriene C4/D4 induces P-selectin and sialyl Lewis(x)-dependent alterations in leukocyte kinetics in vivo. Circ Res. 1995 Nov;77(5):879-87.
[5] Kilic E, Spudich A, et al. ABCC1: a gateway for pharmacological compounds to the ischaemic brain. Brain. 2008 Oct;131(Pt 10):2679-89.
[6] Jones TR, Zamboni R, Belley M, Champion E, Charette L, Ford-Hutchinson AW, Frenette R, Gauthier JY, Leger S, Masson P, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28. doi: 10.1139/y89-004. PMID: 2540892.
[7] Tivnan A, Zakaria Z, O'Leary C, Kögel D, Pokorny JL, Sarkaria JN, Prehn JH. Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 2015 Jun 16;9:218. doi: 10.3389/fnins.2015.00218. PMID: 26136652; PMCID: PMC4468867.
[8] Barrington RD, Needs PW, Williamson G, Kroon PA. MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux. Biochem Pharmacol. 2015 Jun 1;95(3):193-200. doi: 10.1016/j.bcp.2015.03.005. Epub 2015 Mar 20. PMID: 25801004; PMCID: PMC4428793.
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MK-571 sodium 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
1.86mL
0.37mL
0.19mL
9.31mL
1.86mL
0.93mL
18.62mL
3.72mL
1.86mL
MK-571 sodium 技术信息
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