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MK-571 钠盐 /MK-571 sodium {[allProObj[0].p_purity_real_show]}

货号:A407864 同义名: L-660711 sodium;MK-571 Sodium salt Ambeed 开学季,买赠积分,赢豪礼

MK-571 Sodium is a competitive, potent and selective LTD4 antagonist with Ki values of 0.22 nM.

MK-571 sodium 化学结构 CAS号:115103-85-0
MK-571 sodium 化学结构
CAS号:115103-85-0
MK-571 sodium 3D分子结构
CAS号:115103-85-0
MK-571 sodium 化学结构 CAS号:115103-85-0
MK-571 sodium 3D分子结构 CAS号:115103-85-0
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MK-571 sodium 纯度/质量文件 产品仅供科研

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产品名称 LTR 其他靶点 纯度
Montelukast Sodium {[allProObj[0].p_purity_real_show]}
MK571 {[allProObj[0].p_purity_real_show]}
Zafirlukast {[allProObj[0].p_purity_real_show]}
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。

MK-571 sodium 生物活性

描述 Leukotrienes (LT) C4, D4s and E4 are thought to play a fundamental role in lung pathophysislogy. MK-571 Sodium is a potent and selective LTD4 receptor antagonist with Ki values of 0.22 nM and 2.1 nM in guinea pig and human lung membranes, respectively[6]. MK571 is also a multidrug resistance protein-2 (ABCC2, Mrp2) inhibitor. MK571 treatment at 25 μM showed an enhanced effect of vincristine and etoposide in reducing cell viability over a 72 h period in GBM tumor biopsy derived cell lines MZ-256 and MZ-304[7]. MK571 (50 μM, 100 μM) dose-dependently inhibited the intracellular biosynthesis of all flavonol glucuronides and sulphates by Caco-2 cells. MK571 significantly inhibited phase-2 conjugation of kaempferol by cell-free extracts of Caco-2, and production of kaempferol-40-O-glucuronide, which indicated that MK571 is a potential inhibitor of enterocyte phase-2 conjugation[8].

MK-571 sodium 动物研究

Dose Guinea pig: 2 mg/kg[3] (i.v.) Rat: 30 mg/kg[4] (i.v.) Mice: 10 mg/kg[5] (i.p.)
Administration i.v., i.p.

MK-571 sodium 参考文献

[1]Tivnan A, Zakaria Z, et al. Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 2015 Jun 16;9:218.

[2]Jones TR, Zamboni R, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28.

[3]Yang XX, Powell WS, et al. Hyperpnea-induced bronchoconstriction is dependent on tachykinin-induced cysteinyl leukotriene synthesis. J Appl Physiol (1985). 1997 Feb;82(2):538-44.

[4]Kanwar S, Johnston B, et al. Leukotriene C4/D4 induces P-selectin and sialyl Lewis(x)-dependent alterations in leukocyte kinetics in vivo. Circ Res. 1995 Nov;77(5):879-87.

[5]Kilic E, Spudich A, et al. ABCC1: a gateway for pharmacological compounds to the ischaemic brain. Brain. 2008 Oct;131(Pt 10):2679-89.

[6]Jones TR, Zamboni R, Belley M, Champion E, Charette L, Ford-Hutchinson AW, Frenette R, Gauthier JY, Leger S, Masson P, et al. Pharmacology of L-660,711 (MK-571): a novel potent and selective leukotriene D4 receptor antagonist. Can J Physiol Pharmacol. 1989 Jan;67(1):17-28. doi: 10.1139/y89-004. PMID: 2540892.

[7]Tivnan A, Zakaria Z, O'Leary C, Kögel D, Pokorny JL, Sarkaria JN, Prehn JH. Inhibition of multidrug resistance protein 1 (MRP1) improves chemotherapy drug response in primary and recurrent glioblastoma multiforme. Front Neurosci. 2015 Jun 16;9:218. doi: 10.3389/fnins.2015.00218. PMID: 26136652; PMCID: PMC4468867.

[8]Barrington RD, Needs PW, Williamson G, Kroon PA. MK571 inhibits phase-2 conjugation of flavonols by Caco-2/TC7 cells, but does not specifically inhibit their apical efflux. Biochem Pharmacol. 2015 Jun 1;95(3):193-200. doi: 10.1016/j.bcp.2015.03.005. Epub 2015 Mar 20. PMID: 25801004; PMCID: PMC4428793.

MK-571 sodium 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.86mL

0.37mL

0.19mL

9.31mL

1.86mL

0.93mL

18.62mL

3.72mL

1.86mL

MK-571 sodium 技术信息

CAS号115103-85-0
分子式C26H26ClN2NaO3S2
分子量 537.069
别名 L-660711 sodium;MK-571 Sodium salt;MK-571 (sodium salt);L-660711 sodium salt;L-660711
运输蓝冰
存储条件

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

H2O: 30 mg/mL(55.86 mM),配合低频超声助溶

动物实验配方
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