Syrian hamsters exposed to aerosolized lysozyme (20 mg in 20 ml of water for 50 minutes) prior to elastase administration exhibit significantly increased airspace enlargement, indicating an impact on pulmonary structure^[3].

Lysozyme is a ubiquitous enzyme, with hen egg whites being its most abundant source, constituting about 3.4% of the albumen proteins. It functions as a natural antimicrobial agent by hydrolyzing the β(1-4) glycosidic linkage between N-acetylmuramic acid and N-acetylglucosamine, components of the peptidoglycan layer in bacterial cell walls, thus causing cell lysis. While lysozyme's bactericidal impact is predominantly against gram-positive bacteria, including pathogens like Listeria monocytogenes and some Clostridium species, as well as spoilage organisms like thermophilic spore-forming bacteria and certain yeasts, gram-negative bacteria exhibit greater resistance due to their more complex cell wall structures^[1].

Moreover, at a concentration of 1 mg/mL, lysozyme disrupts the protective capacity of hyaluronan (HA) against elastase damage to elastic fibers, indicating its potential impact on tissue integrity and inflammation processes^[3].