Lomitapide | AEGR-733 | MTP Inhibitor | AmBeed-信号通路专用抑制剂

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洛美他派 /Lomitapide {[allProObj[0].p_purity_real_show]}

货号：A647518 同义名： AEGR-733;BMS-201038

Lomitapide is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.

Lomitapide 化学结构
CAS号：182431-12-5

Lomitapide 3D分子结构
CAS号：182431-12-5

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Lomitapide 纯度/质量文件产品仅供科研

货号：A647518 标准纯度： {[allProObj[0].p_purity_real_show]} 产品说明书

批次查询：批次纯度: COA SDS NMR HPLC CNMR LC-MS

全球学术期刊中引用的产品: • JMC, 2024. Ambeed. [ A919389 , A918471 , A995972 ]; • Anal. Chem., 2024, 96(50): 19947-19954. Ambeed. [ A261947 , A1165388 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A220462 ]; • ACS Biomater. Sci. Eng., 2024. Ambeed. [ A165235 , A110205 ]; • Pharmaceutics, 2024, 16(12): 1546. Ambeed. [ A272538 , A187261 , A691302 , A506702 ]; 更多 >

Lomitapide 生物活性

描述	Lomitapide is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.

Lomitapide 临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点
NCT00474240	Hypercholesterolemia	Phase 2	Completed	-	United States, Alabama ... 展开 >> Medical Affiliated Research Center Huntsville, Alabama, United States, 35801 United States, Florida Jacksonville Center for Clinical research Jacksonville, Florida, United States, 32205 Jacksonville Center For Clinical Research Jacksonville, Florida, United States, 32216 Renstar Medical Research Ocala, Florida, United States, 34471 United States, Georgia North Georgia Clinical Research Woodstock, Georgia, United States, 30189 United States, Illinois Radiant Research Chicago, Illinois, United States, 60610 United States, Indiana Medsphere Medical Research Center Evansville, Indiana, United States, 47714 Midwest Institute for Clinical Research Indianapolis, Indiana, United States, 46260 United States, Maine Maine Research Associates Auburn, Maine, United States, 04210 United States, Maryland Health Trends Research Baltimore, Maryland, United States, 21209 United States, North Carolina Piedmont Medical Research Associates Winston-Salem, North Carolina, United States, 27103 United States, Ohio Sterling Research Group Cincinnati, Ohio, United States, 45246 United States, South Carolina Coastal Carolina Research Center Goose Creek, South Carolina, United States, 29445 United States, Texas Dallas Diabetes and Endocrine Center Dallas, Texas, United States, 75230 Diabetes and Glandular Disease Research Dallas, Texas, United States, 78229 United States, Virginia Hampton Roads Center for Clinical Research Norfolk, Virginia, United States, 23502 National Clinical Research Richmond, Virginia, United States, 23294 收起 <<
NCT00474240	-		Completed	-	-
NCT00559962	-		Completed	-	-

Lomitapide 参考文献

[1]Davis KA, Miyares MA. Lomitapide: A novel agent for the treatment of homozygous familial hypercholesterolemia. Am J Health Syst Pharm. 2014 Jun 15;71(12):1001-8.

[2]Sulsky R, Robl JA, et al. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5067-70.

Lomitapide 实验方案

计算器

存储液制备

1mg

5mg

10mg

1 mM

5 mM

10 mM

1.44mL

0.29mL

0.14mL

7.21mL

1.44mL

0.72mL

14.42mL

2.88mL

1.44mL

Lomitapide 技术信息

CAS号	182431-12-5
分子式	C₃₉H₃₇F₆N₃O₂
分子量	693.72

别名	AEGR-733;BMS-201038;AEGR 773
运输	蓝冰

存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Sealed in dry,2-8°C

溶解方案

细胞实验：

DMSO: 105 mg/mL(151.36 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

动物实验：请根据您的动物给药指南选择适当的溶解方案。
以下溶解方案都请先按照体外实验的方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议现用现配，当天使用；以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

方案一

方案二

动物实验配方

临床研究

NCT号	适应症或疾病	临床期	招募状态	预计完成时间	地点

NCT00474240	Hypercholesterolemia	Phase 2	Completed	-	United States, Alabama ... 展开 >> Medical Affiliated Research Center Huntsville, Alabama, United States, 35801 United States, Florida Jacksonville Center for Clinical research Jacksonville, Florida, United States, 32205 Jacksonville Center For Clinical Research Jacksonville, Florida, United States, 32216 Renstar Medical Research Ocala, Florida, United States, 34471 United States, Georgia North Georgia Clinical Research Woodstock, Georgia, United States, 30189 United States, Illinois Radiant Research Chicago, Illinois, United States, 60610 United States, Indiana Medsphere Medical Research Center Evansville, Indiana, United States, 47714 Midwest Institute for Clinical Research Indianapolis, Indiana, United States, 46260 United States, Maine Maine Research Associates Auburn, Maine, United States, 04210 United States, Maryland Health Trends Research Baltimore, Maryland, United States, 21209 United States, North Carolina Piedmont Medical Research Associates Winston-Salem, North Carolina, United States, 27103 United States, Ohio Sterling Research Group Cincinnati, Ohio, United States, 45246 United States, South Carolina Coastal Carolina Research Center Goose Creek, South Carolina, United States, 29445 United States, Texas Dallas Diabetes and Endocrine Center Dallas, Texas, United States, 75230 Diabetes and Glandular Disease Research Dallas, Texas, United States, 78229 United States, Virginia Hampton Roads Center for Clinical Research Norfolk, Virginia, United States, 23502 National Clinical Research Richmond, Virginia, United States, 23294 收起 <<
NCT00474240	-		Completed	-	-
NCT00559962	-		Completed	-	-
NCT00359281	Healthy	Phase 2	Completed	-	United States, Pennsylvania ... 展开 >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 收起 <<
NCT00559962	Hyperlipidemia	Phase 2	Completed	-	United States, California ... 展开 >> Scripps Clinic San Diego, California, United States, 92128 Radiant Research Santa Rosa, California, United States, 95405 United States, District of Columbia MedStar Research Institute Washington, District of Columbia, United States, 20003 United States, Illinois Radiant Research Chicago, Illinois, United States, 60610 United States, Iowa University of Iowa Iowa City, Iowa, United States, 52242 United States, Kentucky LMARC Louisville, Kentucky, United States, 40213 United States, Maine Maine Research Associates Auburn, Maine, United States, 04210 United States, Maryland Health Trends Research Baltimore, Maryland, United States, 21209 Johns Hopkins Baltimore, Maryland, United States, 21287 United States, Missouri Washington Univ. School of Medicine Saint Louis, Missouri, United States, 63110 United States, Ohio Sterling Research Group Cincinnati, Ohio, United States, 45219 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 United States, Texas Baylor College of Medicine Houston, Texas, United States, 77030 Clinical Trial Network Houston, Texas, United States, 77074 dgd Research San Antonio, Texas, United States, 78229 收起 <<
NCT00405067	Hypercholesterolemia	Phase 2	Completed	-	United States, New Jersey ... 展开 >> Pharmanet, Inc Princeton, New Jersey, United States, 08540-6242 收起 <<
NCT00405067	-		Completed	-	-
NCT00690443	-		Completed	-	-
NCT00690443	Hypercholesterolemia	Phase 2	Completed	-	United States, Florida ... 展开 >> Linda Murray, DO - Radiant Research Pinellas Park, Florida, United States, 33781 United States, Minnesota Sheila Rodstein, MD Edina, Minnesota, United States, 55435 United States, Ohio Dennis McCluskey, MD - Radiant Research Mogadore, Ohio, United States, 44260 United States, Texas Michele Reynolds, MD Dallas, Texas, United States, 75231 William Jennings, MD - Radiant Research San Antonio, Texas, United States, 78229 收起 <<
NCT00730236	Homozygous Familial Hyperchole... 展开 >>sterolemia 收起 <<	Phase 3	Completed	-	United States, California ... 展开 >> Cedars-Sinai Medical Center Los Angeles, California, United States, 90048 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Canada, Ontario Robarts Research Institute London, Ontario, Canada, N6A 5K8 Canada, Quebec Lipid Clinic and University of Montreal Community Genomic Medicine Center Chicoutimi, Quebec, Canada, G7H 5H6 Italy Dipartimento di Medicina Clinica e Della Patalogie Emergenti Palermo, Sicily, Italy Medicina Interna Universitaria Ferrara, Italy Centro Universitario Dislipidemie Milano, Italy Dipartimento di Clinica e Terapia Medica Roma, Italy South Africa Cardiology Research Bloemfontein, South Africa, 9300 University of Capetown Cape town, South Africa, 7925 收起 <<
NCT00730236	-		Completed	-	-
NCT01760187	Healthy Volunteer	Phase 1	Completed	-	United Kingdom ... 展开 >> Richmond Pharmacology Ltd Croydon, Surrey, United Kingdom, CR7 7YE 收起 <<
NCT01556906	Homozygous Familial Hyperchole... 展开 >>sterolemia 收起 <<	Phase 2	Completed	-	United States, Pennsylvania ... 展开 >> University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 收起 <<
NCT01556906	-		Completed	-	-
NCT01915771	Intra-subject Variability of P... 展开 >>harmacokinetics 收起 <<	Phase 1	Completed	-	United Kingdom ... 展开 >> Richmond Pharmacology Croydon, Surrey, United Kingdom, CR7 7YE 收起 <<
NCT02399839	-		Enrolling by invitation	March 2028	-
NCT00359281	-		Completed	-	-
NCT02080468	Healthy	Phase 1	Completed	-	United States, Texas ... 展开 >> Covance Clinical Research Unit, Inc Dallas, Texas, United States, 75247 收起 <<
NCT00943306	Familial Hypercholesterolemia	Phase 3	Completed	-	United States, California ... 展开 >> Cedars-Sinai Medical Center Los Angeles, California, United States, 90048 United States, Pennsylvania University of Pennsylvania Philadelphia, Pennsylvania, United States, 19104 Canada, Ontario Robarts Research Institute London, Ontario, Canada, N6A 5K8 Canada, Quebec Lipid Clinic and University of Montreal Community Genomic Medicine Center Chicoutimi, Quebec, Canada, G7H 5H6 Italy Medicina Interna Universitaria Ferrara, Sicily, Italy Dipartimento di Medicina Clinica e Delle Patologie Emergenti Palermo, Sicily, Italy Centro Universitario Dislipidemie Milano, Italy DAI Ematologia, Oncologia, Anatomia Patologica e Medicina Roma, Italy South Africa Cardiology Research Bloemfontein, South Africa, 9300 University of Capetown Cape town, South Africa, 7925 收起 <<
NCT00943306	-		Completed	-	-
NCT02135705	-		Enrolling by invitation	September 2028	United States, Michigan ... 展开 >> Complete Family Care Sterling Heights, Michigan, United States, 48314 收起 <<
NCT02765841	Homozygous Familial Hyperchole... 展开 >>sterolemia 收起 <<	Phase 3	Withdrawn	December 2019	-
NCT02044419	Healthy	Phase 1	Completed	-	United Kingdom ... 展开 >> Richmond Pharmacology Ltd Croydon, Surrey, United Kingdom, CR7 7YE 收起 <<
NCT02044419	-		Completed	-	-
NCT02399852	-		Withdrawn	December 2021	-
NCT01760187	-		Completed	-	-
NCT02080455	Effect of Atorvastatin on the ... 展开 >>Pharmacokinetics of Lomitapide 收起 <<	Phase 1	Completed	-	United States, Texas ... 展开 >> Covance Clinical Research Unit, Inc Dallas, Texas, United States, 75247 收起 <<
NCT02173158	-		Completed	-	-
NCT02173158	Familial Hypercholesterolemia ... 展开 >>- Homozygous 收起 <<	Phase 3	Completed	-	Japan ... 展开 >> Kurume-shi, Fukuoka, Japan, 830-8522 Kanazawa, Ishikawa, Japan, 920-8641 Osakashi, Osaka, Japan, 530-00001 Suita-shi, Osaka, Japan, 565-8565 Tokorozawa, Saitama, Japan, 359-1142 Bunkyo-ku, Tokyo, Japan, 113-8519 收起 <<

洛美他派 /Lomitapide {[allProObj[0].p_purity_real_show]}

Lomitapide 纯度/质量文件产品仅供科研

全球学术期刊中引用的产品

Lomitapide 质控信息

Lomitapide 生物活性

Lomitapide 临床研究

Lomitapide 参考文献

Lomitapide 实验方案

Lomitapide 技术信息

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洛美他派 /Lomitapide {[allProObj[0].p_purity_real_show]}

Lomitapide 纯度/质量文件 产品仅供科研

全球学术期刊中引用的产品

Lomitapide 质控信息

Lomitapide 生物活性

Lomitapide 临床研究

Lomitapide 参考文献

Lomitapide 实验方案

Lomitapide 技术信息

最近浏览的产品

大规格询价

摩尔计算器

靶点

总药量计算器

工作液计算器

细胞研究

临床研究

确认信息

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