产品说明书

Lomitapide

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Chemical Structure| 182431-12-5 同义名 : AEGR-733;BMS-201038;AEGR 773
CAS号 : 182431-12-5
货号 : A647518
分子式 : C39H37F6N3O2
纯度 : 98+%
分子量 : 693.72
MDL号 : MFCD16620494
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(151.36 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Lomitapide is an inhibitor of microsomal triglyceride-transfer protein (MTP) wtih in vitro IC50 of 8 nM.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00474240 Hypercholesterolemia Phase 2 Completed - United States, Alabama ... 展开 >> Medical Affiliated Research Center Huntsville, Alabama, United States, 35801 United States, Florida Jacksonville Center for Clinical research Jacksonville, Florida, United States, 32205 Jacksonville Center For Clinical Research Jacksonville, Florida, United States, 32216 Renstar Medical Research Ocala, Florida, United States, 34471 United States, Georgia North Georgia Clinical Research Woodstock, Georgia, United States, 30189 United States, Illinois Radiant Research Chicago, Illinois, United States, 60610 United States, Indiana Medsphere Medical Research Center Evansville, Indiana, United States, 47714 Midwest Institute for Clinical Research Indianapolis, Indiana, United States, 46260 United States, Maine Maine Research Associates Auburn, Maine, United States, 04210 United States, Maryland Health Trends Research Baltimore, Maryland, United States, 21209 United States, North Carolina Piedmont Medical Research Associates Winston-Salem, North Carolina, United States, 27103 United States, Ohio Sterling Research Group Cincinnati, Ohio, United States, 45246 United States, South Carolina Coastal Carolina Research Center Goose Creek, South Carolina, United States, 29445 United States, Texas Dallas Diabetes and Endocrine Center Dallas, Texas, United States, 75230 Diabetes and Glandular Disease Research Dallas, Texas, United States, 78229 United States, Virginia Hampton Roads Center for Clinical Research Norfolk, Virginia, United States, 23502 National Clinical Research Richmond, Virginia, United States, 23294 收起 <<
NCT00474240 - Completed - -
NCT00559962 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.44mL

0.29mL

0.14mL

7.21mL

1.44mL

0.72mL

14.42mL

2.88mL

1.44mL
参考文献

[1]Davis KA, Miyares MA. Lomitapide: A novel agent for the treatment of homozygous familial hypercholesterolemia. Am J Health Syst Pharm. 2014 Jun 15;71(12):1001-8.

[2]Sulsky R, Robl JA, et al. 5-Carboxamido-1,3,2-dioxaphosphorinanes, potent inhibitors of MTP. Bioorg Med Chem Lett. 2004 Oct 18;14(20):5067-70.