Liquiritin apioside (LA), a main flavonoid component of licorice. Intralaryngeal LA treatment significantly attenuated the apneic response to chemical but not mechanical stimulations. LA pretreatment significantly altered the electrophysiological kinetics of CAP-induced currents in laryngeal C neurons by reducing their amplitudes, increasing the rise times, and prolonging the decay times[3]. Treatment with LA concentration-dependently prevented CSE(cigarette smoke extract)-induced cytotoxicity, increase of TGF-β and TNF-α mRNA expression, depletion of GSH and apoptosis in A549 cells. LA at doses 3, 10 and 30 mg/kg dose-dependently inhibited pulmonary neutrophil and macrophage inflammation[4]. Liquiritin apioside moderately inhibited AChE (IC50 = 36.68 µM)[5]. In addition, liquiritin and liquiritin apioside contribute as active substances for the purgative action of DKT(Daiokanzoto), and some antibiotics reduce the purgative action of DKT and sennoside A[6].
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