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Liquiritin apioside

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Chemical Structure| 74639-14-8 同义名 : -
CAS号 : 74639-14-8
货号 : A217043
分子式 : C26H30O13
纯度 : 95%
分子量 : 550.509
MDL号 : MFCD09260034
存储条件:

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(190.73 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Liquiritin apioside (LA), a main flavonoid component of licorice. Intralaryngeal LA treatment significantly attenuated the apneic response to chemical but not mechanical stimulations. LA pretreatment significantly altered the electrophysiological kinetics of CAP-induced currents in laryngeal C neurons by reducing their amplitudes, increasing the rise times, and prolonging the decay times[3]. Treatment with LA concentration-dependently prevented CSE(cigarette smoke extract)-induced cytotoxicity, increase of TGF-β and TNF-α mRNA expression, depletion of GSH and apoptosis in A549 cells. LA at doses 3, 10 and 30 mg/kg dose-dependently inhibited pulmonary neutrophil and macrophage inflammation[4]. Liquiritin apioside moderately inhibited AChE (IC50 = 36.68 µM)[5]. In addition, liquiritin and liquiritin apioside contribute as active substances for the purgative action of DKT(Daiokanzoto), and some antibiotics reduce the purgative action of DKT and sennoside A[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.82mL

0.36mL

0.18mL

9.08mL

1.82mL

0.91mL

18.17mL

3.63mL

1.82mL

参考文献

[1]Hong C, Schuffler A, et al. Identification of NF-κB as Determinant of Posttraumatic Stress Disorder and Its Inhibition by the Chinese Herbal Remedy Free and Easy Wanderer. Front Pharmacol. 2017 Apr 6;8:181.

[2]Guan Y, Li FF, et al. Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury. Fundam Clin Pharmacol. 2012 Aug;26(4):473-83.

[3]Wei W, Gao X, Zhao L, Zhuang J, Jiao Y, Xu F. Liquiritin apioside attenuates laryngeal chemoreflex but not mechanoreflex in rat pups. Am J Physiol Lung Cell Mol Physiol. 2020 Jan 1;318(1):L89-L97

[4]Guan Y, Li FF, Hong L, Yan XF, Tan GL, He JS, Dong XW, Bao MJ, Xie QM. Protective effects of liquiritin apioside on cigarette smoke-induced lung epithelial cell injury. Fundam Clin Pharmacol. 2012 Aug;26(4):473-83

[5]Jeong GS, Kang MG, Lee JY, Lee SR, Park D, Cho M, Kim H. Inhibition of Butyrylcholinesterase and Human Monoamine Oxidase-B by the Coumarin Glycyrol and Liquiritigenin Isolated from Glycyrrhiza uralensis. Molecules. 2020 Aug 26;25(17):3896

[6]Matsui E, Takayama K, Sato E, Okamura N. The influence of glycyrrhiza and antibiotics on the purgative action of sennoside a from Daiokanzoto in mice. Biol Pharm Bull. 2011;34(9):1438-42