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醋酸拉瑞唑来 /Larazotide acetate {[allProObj[0].p_purity_real_show]}

货号：A724380

Larazotide acetate是一种合成肽，作为紧密连接调节剂，可逆转渗漏的连接为正常闭合状态，具有抗病毒活性，并可用于乳糜泻和感染的研究。

Larazotide acetate 化学结构 CAS号：881851-50-9
Larazotide acetate 化学结构
CAS号：881851-50-9
Larazotide acetate 3D分子结构
CAS号：881851-50-9
Larazotide acetate 化学结构 CAS号：881851-50-9
Larazotide acetate 3D分子结构 CAS号：881851-50-9
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Larazotide acetate 纯度/质量文件 产品仅供科研

货号：A724380 标准纯度： {[allProObj[0].p_purity_real_show]}
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Larazotide acetate 生物活性

描述 Tight junctions (TJs) are located at the apico-lateral borders of adjoining epithelial cells, regulating the patency of the paracellular space and limiting the bidirectional diffusion of particles, water, and solutes across mucosal surfaces. Larazotide acetate, an 8-mer peptide, acts as a tight junction regulator and inhibits the cellular changes elicited by gliadin fragments, AT-1002, and cytokines. In Caco-2 cells, larazotide acetate at 15 and 12.5 mM significantly inhibited the AT-1002-induced increase in LY passage by 71 and 38%, respectively. PTG-induced ZO-1 redistribution was inhibited by larazotide acetate (12.5 mM; 1 h) and the junctional ZO-1 fluorescence intensity was maintained at near control levels. Furthermore, in IEC6 cells treated with PTG and larazotide acetate (12.5 mM), the actin network was protected from disassembly. In vivo, larazotide acetate inhibited gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice[2].

Larazotide acetate 参考文献

[1]Gopalakrishnan S, et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94.

[2]Gopalakrishnan S, Durai M, Kitchens K, Tamiz AP, Somerville R, Ginski M, Paterson BM, Murray JA, Verdu EF, Alkan SS, Pandey NB. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94.

Larazotide acetate 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.27mL

0.25mL

0.13mL

6.36mL

1.27mL

0.64mL

12.72mL

2.54mL

1.27mL

Larazotide acetate 技术信息

CAS号881851-50-9
分子式C34H59N9O12
分子量 785.885
别名
运输蓝冰
存储条件

In solvent -20°C:3-6个月-80°C:12个月

Pure form Inert atmosphere,Store in freezer, under -20°C
溶解方案

DMSO: 3 mg/mL(3.82 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 15 mg/mL(19.09 mM)，配合低频超声助溶

配制的工作液建议现用现配，短期内尽快用完。 以下溶剂前显示的百分比是指该溶剂在终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶。
方案一
动物实验配方

Tags: Larazotide | 881851-50-9 | Gap Junction Protein | peptide | Zonulin Antagonist | Cytoskeleton | Gap Junction Protein | 仅供科研使用 | AmBeed-信号通路专用抑制剂 | Larazotide acetate 纯度/质量文件 | Larazotide acetate 生物活性 | Larazotide acetate 参考文献 | Larazotide acetate 实验方案 | Larazotide acetate 技术信息

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