GAP-134, a small modified dipeptide, has been identified as a potent and selective second generation gap junction modifier with oral bioavailability.

Larazotide acetate is a synthetic peptide. Larazotide acetate acts as a tight junction regulator and reverses leaky junctions to their normally closed state.

Gap19 是一种选择性的间隙连接抑制剂，对 Connexin43 (Cx43) 具有高亲和力，IC50 值为 1 μM。Gap19 能抑制间隙连接通道的功能，主要用于心血管疾病和肿瘤研究。

Rotigaptide是一种特异性连接蛋白 43 (Cx43) 调节剂，能够防止 Cx43 介导的间隙连接通讯解偶联，并在急性代谢应激期间恢复细胞间的正常通讯。该肽类化合物具有潜力用于心律失常，特别是房颤的相关研究。

Meclofenamic acid is a balanced COX-1/COX-2 inhibitor and a non-selective gap junction blocker.

GAP-134 hydrochloride 是一种小型修饰二肽，已被确定为一种强效、选择性、第二代gap-junction 修饰剂，具有口服生物利用度。

Gap 26, a mimetic peptide of connexin, is the gap junction blocker that corresponds to the residues 63-75 of connexin 43.

Gap 27 is peptide derived from connexin 43 that is a selective gap junction blocker. 

Tonabersat is a gap-junction modulator.