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Larazotide acetate

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Chemical Structure| 881851-50-9 同义名 : -
CAS号 : 881851-50-9
货号 : A724380
分子式 : C34H59N9O12
纯度 : 99%+
分子量 : 785.885
MDL号 : MFCD31630844
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 3 mg/mL(3.82 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 15 mg/mL(19.09 mM)，配合低频超声助溶
动物实验配方：
生物活性
描述 Tight junctions (TJs) are located at the apico-lateral borders of adjoining epithelial cells, regulating the patency of the paracellular space and limiting the bidirectional diffusion of particles, water, and solutes across mucosal surfaces. Larazotide acetate, an 8-mer peptide, acts as a tight junction regulator and inhibits the cellular changes elicited by gliadin fragments, AT-1002, and cytokines. In Caco-2 cells, larazotide acetate at 15 and 12.5 mM significantly inhibited the AT-1002-induced increase in LY passage by 71 and 38%, respectively. PTG-induced ZO-1 redistribution was inhibited by larazotide acetate (12.5 mM; 1 h) and the junctional ZO-1 fluorescence intensity was maintained at near control levels. Furthermore, in IEC6 cells treated with PTG and larazotide acetate (12.5 mM), the actin network was protected from disassembly. In vivo, larazotide acetate inhibited gliadin-induced macrophage accumulation in the intestine and preserved normal tight junction structure in gliadin-sensitized HLA-HCD4/DQ8 double transgenic mice[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.27mL

0.25mL

0.13mL

6.36mL

1.27mL

0.64mL

12.72mL

2.54mL

1.27mL
参考文献

[1]Gopalakrishnan S, et al. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94.

[2]Gopalakrishnan S, Durai M, Kitchens K, Tamiz AP, Somerville R, Ginski M, Paterson BM, Murray JA, Verdu EF, Alkan SS, Pandey NB. Larazotide acetate regulates epithelial tight junctions in vitro and in vivo. Peptides. 2012 May;35(1):86-94.