LY255283 is selective, competitive antagonist of BLT2 receptors (IC50 values are ~ 1 and > 10 μM at human recombinant BLT2 and BLT1 receptors respectively), and inhibits LTB4-induced contraction of lung parenchyma (pA2 = 7.2), and reduces LTB4-mediated airway obstruction in guinea pigs following i.v. and oral administration.
There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type | HazMat fee for 500 gram (Estimated) |
Excepted Quantity | USD 0.00 |
Limited Quantity | USD 15-60 |
Inaccessible (Haz class 6.1), Domestic | USD 80+ |
Inaccessible (Haz class 6.1), International | USD 150+ |
Accessible (Haz class 3, 4, 5 or 8), Domestic | USD 100+ |
Accessible (Haz class 3, 4, 5 or 8), International | USD 200+ |
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快速发货 顺丰冷链运输,1-2 天到达
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技术支持
免费溶解
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MK571 | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
Zafirlukast | ✔ | {[allProObj[0].p_purity_real_show]} | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | LY255283 is an antagonist to the LTB4 receptor (BLT2), demonstrating an IC50 of approximately 100 nM for blocking [3H]LTB4 binding in guinea pig lung membranes[1].[2].[3].[4]. |
体内研究 | In pig models, LY255283 administered at doses of 3 and 30 mg/kg significantly alleviates lipopolysaccharide-induced acute respiratory distress syndrome (ARDS), likely through inhibiting the infiltration of activated polymorphonuclear neutrophils (PMNs) into the alveoli in a dose-responsive manner[3]. Furthermore, at a dosage of 2.5 mg/kg (intraperitoneally), it hinders the metastasis of transitional cell carcinoma in mouse models, indicating the critical involvement of a BLT2–Nox–ROS–NF–κB pathway in bladder cancer invasion and metastasis[4]. |
体外研究 | LY255283 effectively competes with LTB4, diminishing contractile responses in lung parenchyma (pA2 = 7.2)[2]. Administered at a concentration of 10 μM for 7 days, LY255283 notably reduces the invasiveness of 253 J-BV bladder cancer cells, which are known for their high aggressiveness[4]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
2.77mL 0.55mL 0.28mL |
13.87mL 2.77mL 1.39mL |
27.74mL 5.55mL 2.77mL |
CAS号 | 117690-79-6 |
分子式 | C19H28N4O3 |
分子量 | 360.451 |
别名 | |
运输 | 蓝冰 |
存储条件 |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(291.3 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |