There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
LY255283 is an antagonist to the LTB4 receptor (BLT2), demonstrating an IC50 of approximately 100 nM for blocking [3H]LTB4 binding in guinea pig lung membranes[1].[2].[3].[4].
体内研究
In pig models, LY255283 administered at doses of 3 and 30 mg/kg significantly alleviates lipopolysaccharide-induced acute respiratory distress syndrome (ARDS), likely through inhibiting the infiltration of activated polymorphonuclear neutrophils (PMNs) into the alveoli in a dose-responsive manner[3].
Furthermore, at a dosage of 2.5 mg/kg (intraperitoneally), it hinders the metastasis of transitional cell carcinoma in mouse models, indicating the critical involvement of a BLT2–Nox–ROS–NF–κB pathway in bladder cancer invasion and metastasis[4].
体外研究
LY255283 effectively competes with LTB4, diminishing contractile responses in lung parenchyma (pA2 = 7.2)[2].
Administered at a concentration of 10 μM for 7 days, LY255283 notably reduces the invasiveness of 253 J-BV bladder cancer cells, which are known for their high aggressiveness[4].
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