KY02111
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货号：A360800
KY02111 can inhibit Wnt signaling and promote differentiation of hPSCs to cardiomyocytes.
KY02111 化学结构
KY02111 3D分子结构
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KY02111 纯度/质量文件 产品仅供科研
货号：A360800
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KY02111 质控信息
KY02111 生物活性
描述
Wnt signaling is one of the key cascades regulating development and stemness, and has also been tightly associated with cancer[6] 50 of 25 nM[7] 2 or ~1.5 per input human embryonic stem cell (hESC)). In addition, IWP-4 induced expression of both atrial (MLC2a) and ventricular (MLC2v) forms[7] [8]
KY02111 参考文献
[1] Minami I, Yamada K, et al. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2012 Nov 29;2(5):1448-60.
[2] Zhan T, Rindtorff N, Boutros M. Wnt signaling in cancer. Oncogene. 2017 Mar;36(11):1461-1473.
[3] Minami I, Yamada K, Otsuji TG, Yamamoto T, Shen Y, Otsuka S, Kadota S, Morone N, Barve M, Asai Y, Tenkova-Heuser T, Heuser JE, Uesugi M, Aiba K, Nakatsuji N. A small molecule that promotes cardiac differentiation of human pluripotent stem cells under defined, cytokine- and xeno-free conditions. Cell Rep. 2012 Nov 29;2(5):1448-60.
[4] Morgan JT, Raghunathan VK, Chang YR, Murphy CJ, Russell P. Wnt inhibition induces persistent increases in intrinsic stiffness of human trabecular meshwork cells. Exp Eye Res. 2015 Mar;132:174-8.
[5] Surface LE, Fields PA, Subramanian V, Behmer R, Udeshi N, Peach SE, Carr SA, Jaffe JD, Boyer LA. H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs. Cell Rep. 2016 Feb 9;14(5):1142-1155.
[6] Zhan T, Rindtorff N, Boutros M. Wnt signaling in cancer. Oncogene. 2017 Mar;36(11):1461-1473. doi: 10.1038/onc.2016.304. Epub 2016 Sep 12. PMID: 27617575; PMCID: PMC5357762.
[7] Hudson J, Titmarsh D, Hidalgo A, Wolvetang E, Cooper-White J. Primitive cardiac cells from human embryonic stem cells. Stem Cells Dev. 2012 Jun 10;21(9):1513-23. doi: 10.1089/scd.2011.0254. Epub 2011 Nov 9. PMID: 21933026.
[8] Frith JE, Titmarsh DM, Padmanabhan H, Cooper-White JJ. Microbioreactor array screening of Wnt modulators and microenvironmental factors in osteogenic differentiation of mesenchymal progenitor cells. PLoS One. 2013 Dec 23;8(12):e82931. doi: 10.1371/journal.pone.0082931. PMID: 24376608; PMCID: PMC3871528.
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KY02111 实验方案
计算器
摩尔计算器
总药量计算器
工作液计算器
存储液制备
1mg
5mg
10mg
1 mM
5 mM
10 mM
2.65mL
0.53mL
0.27mL
13.27mL
2.65mL
1.33mL
26.54mL
5.31mL
2.65mL
KY02111 技术信息
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