There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
KG-548 is an ARNT/TACC3 binding blocker and HIF-1α inhibitor. KG-548 directly interferes with the formation of the ARNT/TACC3 complex by competing with TACC3 for binding to the PAS-B structural domain of ARNT. ARNT is an aryl hydrocarbon receptor nuclear transporter, also known as HIF-β[1][2].At concentrations of 0-250 μM for 16 hours to overnight, KG-548 significantly reduces the formation of the ARNT/CCC complex of both co-activators and also disrupts the ARNT2 PAS-B/TACC3 interaction. And at concentrations of 0-2 mM, KG-548 dose-dependently disassembled (320 μM) ARNT PAS-B/TACC3 complexes in vitro and in cell lysates with an IC50 value of 25 μM[1].KG-548 significantly inhibited lactate production from glycolysis in FaDu cells[2] .
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HazMat Fee +
