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甲氧番荔枝碱 /JTE-607 {[allProObj[0].p_purity_real_show]}

货号:A1493432 同义名: JTE 607二盐酸盐 / JTE-607 Dihydrochloride Ambeed 开学季,买赠积分,赢豪礼

JTE-607 is a small molecule that was developed as an inflammatory cytokine inhibitor, which directly targets CPSF3 and inhibits pre-mRNA processing.

JTE-607 化学结构 CAS号:188791-09-5
JTE-607 化学结构
CAS号:188791-09-5
JTE-607 3D分子结构
CAS号:188791-09-5
JTE-607 化学结构 CAS号:188791-09-5
JTE-607 3D分子结构 CAS号:188791-09-5
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JTE-607 纯度/质量文件 产品仅供科研

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JTE-607 生物活性

描述 JTE-607 is a highly selective inhibitor of inflammatory cytokine synthesis that protects mice from endotoxic shock. JTE-607 inhibits LPS-stimulated inflammatory cytokines produced by human PBMC, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, with IC50 values of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively, and the mRNA expression of these cytokines was also inhibited by JTE-607[1].JTE607 inhibits LPS-stimulated IL-8 production by monkey and rabbit PBMC, and TNF-α production by mouse and rat PBMC with IC50 values ​​of 59, 780, 1600, and 19000 nM, respectively. JTE-607 can also inhibit other cytokines, granulocyte-macrophage colony-stimulating factor and IL-1RA, with IC50 of 2.4±0.8 and 5.4±0.4 nM respectively[1].

JTE-607 动物研究

Animal study Sensitisation by injection of Corynebacterium parvum and LPS challenge resulted in the death of male C57BL/6 mice. In contrast, JTE-607 dose-dependently suppresses mortality when administered intravenously at doses of 0.3-10 mg/kg[1].

JTE-607 参考文献

[1]M Kakutani, et al. JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm Res. 1999 Aug;48(8):461-8.

JTE-607 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.67mL

0.33mL

0.17mL

8.37mL

1.67mL

0.84mL

16.74mL

3.35mL

1.67mL

JTE-607 技术信息

CAS号188791-09-5
分子式C25H33Cl4N3O5
分子量 597.359
别名 JTE 607二盐酸盐 ;JTE-607 Dihydrochloride
运输蓝冰
存储条件

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月

溶解度

DMSO: 250 mg/mL(418.51 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 20 mg/mL(33.48 mM),配合低频超声,并水浴加热至45℃助溶

动物实验配方
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