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JTE-607

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Chemical Structure| 188791-09-5 同义名 : JTE 607二盐酸盐 ;JTE-607 Dihydrochloride
CAS号 : 188791-09-5
货号 : A1493432
分子式 : C25H33Cl4N3O5
纯度 : 98%
分子量 : 597.359
MDL号 : MFCD07363998
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(418.51 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 20 mg/mL(33.48 mM)，配合低频超声，并水浴加热至45℃助溶
动物实验配方：
生物活性
描述 JTE-607 is a highly selective inhibitor of inflammatory cytokine synthesis that protects mice from endotoxic shock. JTE-607 inhibits LPS-stimulated inflammatory cytokines produced by human PBMC, including TNF-α, IL-1β, IL-6, IL-8 and IL-10, with IC50 values of 11, 5.9, 8.8, 7.3 and 9.1 nM, respectively, and the mRNA expression of these cytokines was also inhibited by JTE-607[1].JTE607 inhibits LPS-stimulated IL-8 production by monkey and rabbit PBMC, and TNF-α production by mouse and rat PBMC with IC50 values ​​of 59, 780, 1600, and 19000 nM, respectively. JTE-607 can also inhibit other cytokines, granulocyte-macrophage colony-stimulating factor and IL-1RA, with IC50 of 2.4±0.8 and 5.4±0.4 nM respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.67mL

0.33mL

0.17mL

8.37mL

1.67mL

0.84mL

16.74mL

3.35mL

1.67mL
参考文献

[1]M Kakutani, et al. JTE-607, a novel inflammatory cytokine synthesis inhibitor without immunosuppression, protects from endotoxin shock in mice. Inflamm Res. 1999 Aug;48(8):461-8.