货号:A245799 同义名: Ipragliflozin L-Proline
Ipragliflozin (L-Proline) selectively inhibits SGLT2 with IC50 of 2.8 nM.
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产品名称 | SGLT1 ↓ ↑ | SGLT2 ↓ ↑ | 其他靶点 | 纯度 | |||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Phloretin | ✔ | 98% | |||||||||||||||||
Canagliflozin |
+++
hSGLT2, IC50: 3.7 nM mSGLT2, IC50: 2 nM |
95% | |||||||||||||||||
Empagliflozin |
++
SGLT2, IC50: 3.1 nM |
98% | |||||||||||||||||
Dapagliflozin |
++++
hSGLT2, EC50: 1.1 nM |
97% | |||||||||||||||||
Tofogliflozin (hydrate) |
+++
hSGLT2, IC50: 2.9 nM |
99%+ | |||||||||||||||||
Sotagliflozin |
+
SGLT1, IC50: 36 nM |
++++
SGLT2, IC50: 1.8 nM |
98% | ||||||||||||||||
Ipragliflozin |
++
hSGLT2, IC50: 7.4 nM |
98% | |||||||||||||||||
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多,抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用,但抑制强度暂时没有相关数据。 |
描述 | Ipragliflozin (L-Proline) potently and selectively inhibits human, rat, and mouse SGLT2 at nanomolar concentrations and exhibits stability against intestinal glucosidases[3]. |
体内研究 | Ipragliflozin (L-Proline) displays favorable pharmacokinetic properties and dose-dependently increases urinary glucose excretion, lasting for over 12 hours in normal mice[3]. Oral administration of Ipragliflozin increases urinary glucose excretion in a dose-dependent manner, with significant effects observed at doses of 0.3 mg/kg or higher, and this effect persists for over 12 hours[4]. Single administration of Ipragliflozin dose-dependently increases urinary glucose excretion, reduces blood glucose and plasma insulin levels, and improves glucose intolerance[1]. |
体外研究 | Ipragliflozin (L-Proline) potently and selectively inhibits human, rat, and mouse SGLT2 at nanomolar concentrations and exhibits stability against intestinal glucosidases[3]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
1.92mL 0.38mL 0.19mL |
9.62mL 1.92mL 0.96mL |
19.25mL 3.85mL 1.92mL |
CAS号 | 951382-34-6 |
分子式 | C26H30FNO7S |
分子量 | 519.582 |
别名 | Ipragliflozin L-Proline |
运输 | 蓝冰 |
存储条件 |
液体 -20°C:3-6个月-80°C:12个月 粉末 Inert atmosphere,2-8°C |
溶解度 |
DMSO: 18 mg/mL(34.64 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |