There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.
Type
HazMat fee for 500 gram (Estimated)
Excepted Quantity
USD 0.00
Limited Quantity
USD 15-60
Inaccessible (Haz class 6.1), Domestic
USD 80+
Inaccessible (Haz class 6.1), International
USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic
USD 100+
Accessible (Haz class 3, 4, 5 or 8), International
Sodium glucose co-transporter 2 (SGLT2) is a high-capacity glucose transporter mediating the majority of the glucose resorption in kidney. Canagliflozin is a selective, potent SGLT2 inhibitor with IC50 values of 4.4, 3.7, and 2.0 nM for human SGLT2, rat SGLT2, and mouse SGLT2, respectively. In contrast, canagliflozin inhibited human, rat and mouse SGLT1 with IC50 values of 684, 571, and >1000 nM, respectively. In L6 myoblasts, canagliflozin at 10 μM blocked the non-Na+-linked GLUT-mediated 3H-2-DG uptake by < 50%. Canagliflozin at 10 μM inhibited DNJ-induced currents by 23.4% in SGLT3-injected oocytes, whereas the same treatment of canagliflozin had no effect on currents in water-injected oocytes. In Zucker diabetic fatty (ZDF) rats treated by 1 mg/kg canagliflozin hemihydrate, renal threshold for glucose excretion was reduced from 415 mg/dl to 94 mg/dl at 90 min post treatment. In db/db mice, single dose of canagliflozin (1 and 10 mg/kg) rapidly downregulated non-fasting blood glucose concentration in a dose-dependent manner at 1h post treatment. When ZDF rats were treated with canagliflozin at different doses (3, 10, or 30 mg/kg) for 4 weeks, the non-fasting blood glucose and the level of HbA1c were decreased in all canagliflozin hemihydrate-treated rats compared to control group. Decreased blood glucose level following an oral glucose tolerance test was also observed in canagliflozin hemihydrate-treated rats. Treatment of 30 mg/kg canagliflozin in DIO mice for 4 weeks decreased their blood glucose level, respiratory exchange ratio, and body weight gain compared to vehicle-treated mice[2].
Canagliflozin 细胞研究
细胞系
浓度
检测类型
检测时间
活性说明
数据源
CHO-K1 cells
Function assay
Inhibition of human SGLT2 expressed in CHO-K1 cells by [14C]AMG uptake assay, IC50=6.7 nM
Terminated(On 25April2014, stu... 展开 >>dy was terminated before any dosing due to an AE of safety concern that occurred in protocol B1731003 with the same drug.) 收起 <<
-
United States, Florida
... 展开 >>
Pfizer Investigational Site
DeLand, Florida, United States, 32720 收起 <<
Terminated(On 25April2014, stu... 展开 >>dy was terminated before any dosing due to an AE of safety concern that occurred in protocol B1731003 with the same drug.) 收起 <<
-
United States, Florida
... 展开 >>
Pfizer Investigational Site
DeLand, Florida, United States, 32720 收起 <<
Kuwait
... 展开 >>
Kuwait City, Kuwait
Lebanon
Amioun, Lebanon
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... 展开 >> Research site
Chubu, Japan
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Research site
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Research site
Tohoku, Japan 收起 <<
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... 展开 >>
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Japan
... 展开 >> Reserch site
Chubu, Japan
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United States, Maryland
... 展开 >>
National Institutes of Health Clinical Center, 9000 Rockville Pike
Recruiting
Bethesda, Maryland, United States, 20892
Contact: For more information at the NIH Clinical Center contact Office of Patient Recruitment (OPR) 800-411-1222 ext TTY8664111010 prpl@cc.nih.gov 收起 <<
Japan
... 展开 >> Reserch site
Chubu, Japan
Reserch site
Chugoku, Japan
Reserch site
Hokkaido, Japan
Reserch site
Kanto, Japan
Reserch site
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Kyushu, Japan
Reserch site
Tohoku, Japan 收起 <<
United States, Arizona
... 展开 >>
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Norfolk, Virginia, United States
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Wauwatosa, Wisconsin, United States 收起 <<
United States, District of Col... 展开 >>umbia
The George Washington University Medical Faculty Associates
Recruiting
Washington, District of Columbia, United States, 20037
Contact: Fiona Dore, BS 202-741-2342 fdore@mfa.gwu.edu 收起 <<
Japan
... 展开 >> Research site
Recruiting
Aichi, Japan
Research site
Recruiting
Chiba, Japan
Research site
Recruiting
Fukuoka, Japan
Research site
Recruiting
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Research site
Recruiting
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Research site
Recruiting
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Research site
Recruiting
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Research site
Recruiting
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Recruiting
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Research site
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Research site
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Research site
Recruiting
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Research site
Recruiting
Yamaguchi, Japan 收起 <<
United States, Texas
... 展开 >>
University of Texas Health Science Center at San Antonio
Recruiting
San Antonio, Texas, United States, 78229
Contact: Ralph A DeFronzo, MD 210-567-6691 defronzo@uthscsa.edu
Contact: Monica Palomo, BS 210-567-6710 palomom@uthscsa.edu
Principal Investigator: Ralph A DeFronzo, MD 收起 <<
India
... 展开 >> Diacon Hospital
Recruiting
Bangalore, India, 560010
Dr. A. Ramachandran's Diabetes Hospitals
Not yet recruiting
Chennai, India, 600032
CARE Hospitals
Not yet recruiting
Hydrabad, India, 500001 收起 <<
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... 展开 >>
Little Rock, Arkansas, United States
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Brazil
Campinas, Brazil
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Sao Paulo, Brazil 收起 <<
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