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碘海醇 /Iohexol {[allProObj[0].p_purity_real_show]}

货号:A514163

Iohexol is a non-ionic contrast agent used in myelography.

Iohexol 化学结构 CAS号:66108-95-0
Iohexol 化学结构
CAS号:66108-95-0
Iohexol 3D分子结构
CAS号:66108-95-0
Iohexol 化学结构 CAS号:66108-95-0
Iohexol 3D分子结构 CAS号:66108-95-0
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Iohexol 纯度/质量文件 产品仅供科研

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Iohexol 生物活性

描述 Iohexol is a non-ionic, water-soluble contrast agent used primarily as a reference marker to assess glomerular filtration rate (GFR) in renal function studies. It is also employed in various imaging procedures, such as myelography, computerized tomography (including cisternography and ventriculography), and MicroCT imaging[1].[2].
体内研究

When administered orally at 0.25-4 mL/kg on a weekly basis, iohexol enhances the differentiation of intestinal segments in dogs, particularly after doses ranging from 0.5 to 2.0 mL/kg[4].

Iohexol administered intravenously at a dose of 64.7 mg/kg is utilized to measure the glomerular filtration rate (GFR) in both healthy dogs and those with chronic kidney disease (CKD)[5].

体外研究

Iohexol at a concentration of 150 mg I/mL over a 0-24 hour period reduces cell viability in NRK 52-E cells[3].

Iohexol 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00658359 Kidney Transplantation Phase 2 Completed - -
NCT00554450 Diabetes Mellitus, Type 2 Phase 1 Completed - United States, California ... 展开 >> Advanced Clinical Research Institute Anaheim, California, United States, 92801 United States, Florida Elite Research Institute Miami, Florida, United States, 33169 United States, Minnesota Prism Research St. Paul, Minnesota, United States, 55114 United States, Texas Dgd Research, Inc. San Antonio, Texas, United States, 78229 收起 <<
NCT03453775 Low Back Pain ... 展开 >> Sciatica Disc, Herniated Foraminal Hernia Lumbar Foraminal Stenosis Chronic Low Back Pain Pain, Chronic Injection Site Infiltration 收起 << Not Applicable Recruiting May 30, 2018 Belgium ... 展开 >> Hopital Erasme Recruiting Anderlecht, Bruxelles, Belgium, 1070 Contact    +3225553111 收起 <<

Iohexol 参考文献

[1]Soman RS, et al. Development and validation of an HPLC-UV method for determination of iohexol in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):339-43.

[2]Hainfeld JF, Ridwan SM, Stanishevskiy Y, Smilowitz NR, Davis J, Smilowitz HM. Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging. Sci Rep. 2018 Sep 14;8(1):13803.

[3]Jensen H, et al. The effects of the iodinated X-ray contrast media iodixanol, iohexol, iopromide, and ioversol on the rat kidney epithelial cell line NRK 52-E. Ren Fail. 2011;33(4):426-33.

[4]Klenner S, et al. Estimation of intestinal permeability in healthy dogs using the contrast medium iohexol. Vet Clin Pathol. 2009 Sep;38(3):353-60.

[5]Baklouti S, et al. Population Pharmacokinetic Model of Iohexol in Dogs to Estimate Glomerular Filtration Rate and Optimize Sampling Time. Front Pharmacol. 2021 Apr 29;12:634404.

Iohexol 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

1.22mL

0.24mL

0.12mL

6.09mL

1.22mL

0.61mL

12.18mL

2.44mL

1.22mL

Iohexol 技术信息

CAS号66108-95-0
分子式C19H26I3N3O9
分子量 821.138
别名
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Keep in dark place,Sealed in dry,Room Temperature

溶解度

DMSO: 50 mg/mL(60.89 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(60.89 mM)

动物实验配方
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