产品说明书

Iohexol

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Chemical Structure| 66108-95-0 同义名 : -
CAS号 : 66108-95-0
货号 : A514163
分子式 : C19H26I3N3O9
纯度 : 98%
分子量 : 821.138
MDL号 : MFCD00077732
存储条件:

粉末 Keep in dark place,Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 50 mg/mL(60.89 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(60.89 mM)

动物实验配方:
生物活性
描述 Iohexol is a non-ionic, water-soluble contrast agent used primarily as a reference marker to assess glomerular filtration rate (GFR) in renal function studies. It is also employed in various imaging procedures, such as myelography, computerized tomography (including cisternography and ventriculography), and MicroCT imaging[1].[2].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00658359 Kidney Transplantation Phase 2 Completed - -
NCT00554450 Diabetes Mellitus, Type 2 Phase 1 Completed - United States, California ... 展开 >> Advanced Clinical Research Institute Anaheim, California, United States, 92801 United States, Florida Elite Research Institute Miami, Florida, United States, 33169 United States, Minnesota Prism Research St. Paul, Minnesota, United States, 55114 United States, Texas Dgd Research, Inc. San Antonio, Texas, United States, 78229 收起 <<
NCT03453775 Low Back Pain ... 展开 >> Sciatica Disc, Herniated Foraminal Hernia Lumbar Foraminal Stenosis Chronic Low Back Pain Pain, Chronic Injection Site Infiltration 收起 << Not Applicable Recruiting May 30, 2018 Belgium ... 展开 >> Hopital Erasme Recruiting Anderlecht, Bruxelles, Belgium, 1070 Contact    +3225553111 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.22mL

0.24mL

0.12mL

6.09mL

1.22mL

0.61mL

12.18mL

2.44mL

1.22mL

参考文献

[1]Soman RS, et al. Development and validation of an HPLC-UV method for determination of iohexol in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci. 2005 Feb 25;816(1-2):339-43.

[2]Hainfeld JF, Ridwan SM, Stanishevskiy Y, Smilowitz NR, Davis J, Smilowitz HM. Small, Long Blood Half-Life Iodine Nanoparticle for Vascular and Tumor Imaging. Sci Rep. 2018 Sep 14;8(1):13803.

[3]Jensen H, et al. The effects of the iodinated X-ray contrast media iodixanol, iohexol, iopromide, and ioversol on the rat kidney epithelial cell line NRK 52-E. Ren Fail. 2011;33(4):426-33.

[4]Klenner S, et al. Estimation of intestinal permeability in healthy dogs using the contrast medium iohexol. Vet Clin Pathol. 2009 Sep;38(3):353-60.

[5]Baklouti S, et al. Population Pharmacokinetic Model of Iohexol in Dogs to Estimate Glomerular Filtration Rate and Optimize Sampling Time. Front Pharmacol. 2021 Apr 29;12:634404.