Hyaluronic acid (HA) is prominently utilized in aesthetic medicine for its capability to bind with a multitude of water molecules, thereby enhancing tissue hydration and resistance to mechanical damage. HA plays critical roles in various biological processes including wound healing, ovulation, fertilization, signal transduction, and tumor physiology. It has also been investigated in clinical trials for its potential applications in identifying tumor markers, treating liver diseases, and developing pharmaceuticals^[1].

Hyaluronan significantly influences cancer development and metastasis. The interaction between HA and HA fragments with tumor cells initiates downstream signaling pathways, fostering cell proliferation, adhesion, migration, and invasion. Additionally, this interaction induces angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like properties, and resistance to chemotherapy and radiotherapy, particularly in gastrointestinal cancers^[2].