产品说明书

Hyaluronic acid

Print
Chemical Structure| 9004-61-9 同义名 : 玻尿酸 ;Hyaluronan;Hyaluronate
CAS号 : 9004-61-9
货号 : A998531
分子式 : -
纯度 : 5000 to 150000Da
分子量 : 0
MDL号 : MFCD00131348
存储条件:

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

H2O: 12 mg/mL,配合低频超声助溶

动物实验配方:
生物活性
描述 Hyaluronic acid (HA) is prominently utilized in aesthetic medicine for its capability to bind with a multitude of water molecules, thereby enhancing tissue hydration and resistance to mechanical damage. HA plays critical roles in various biological processes including wound healing, ovulation, fertilization, signal transduction, and tumor physiology. It has also been investigated in clinical trials for its potential applications in identifying tumor markers, treating liver diseases, and developing pharmaceuticals[1]. Hyaluronan significantly influences cancer development and metastasis. The interaction between HA and HA fragments with tumor cells initiates downstream signaling pathways, fostering cell proliferation, adhesion, migration, and invasion. Additionally, this interaction induces angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, stem cell-like properties, and resistance to chemotherapy and radiotherapy, particularly in gastrointestinal cancers[2].
参考文献

[1]Salwowska NM, et al. Physiochemical properties and application of hyaluronic acid: a systematic review. J Cosmet Dermatol. 2016 Dec;15(4):520-526.

[2]Wu RL, et al. Hyaluronic acid in digestive cancers. J Cancer Res Clin Oncol. 2017 Jan;143(1):1-16.