Research involving intra-articular HA, particularly in animal studies, has demonstrated its efficacy. HA has been shown to boost the synthesis of the cartilage matrix, inhibit its degradation, reduce inflammation, stimulate the production of endogenous HA, and enhance the resilience and moisture retention of cartilage^[1].

Moreover, high molecular weight HA formulations, when applied topically, are effective in accelerating the healing of fresh skin wounds. They also play a significant role in treating venous leg ulcers and managing chronic wounds^[3].

Hyaluronic acid (HA) is extensively utilized in aesthetic medicine for its capacity to bind a significant number of water molecules, enhancing tissue hydration and mechanical resistance. HA is pivotal in processes such as wound healing, ovulation, fertilization, signal transduction, and tumor physiology. It is also explored in clinical research for its potential roles in tumor markers, liver diseases, and pharmaceutical applications^[1].

In the realm of oncology, hyaluronan significantly influences cancer progression and metastasis. The interaction between HA and HA fragments with tumor cells triggers downstream signaling pathways, which enhance cell proliferation, adhesion, migration, and invasion. This interaction also promotes angiogenesis, lymphangiogenesis, epithelial-mesenchymal transition, properties akin to stem cells, and resistance to chemotherapy and radiation, particularly in digestive cancers^[2].