己烷雌酚 /Hexestrol
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货号：A228315
同义名：
meso-Hexestrol;Bibenzyl
Hexestrol can bind to ERα and ERβ selectively with EC50 of 0.07 nM and 0.175 nM respectively.
Hexestrol 化学结构
Hexestrol 3D分子结构
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Hexestrol 质控信息
Hexestrol 生物活性
描述
Hexestrol is a estrogen receptor (ER) subtype-selective ligands. Hexestrol binds to ER α and ER β with EC50 of 0.07 nm and 0.175 nm, respectively[3] [4] [5] [6] [7] [8]
Hexestrol 参考文献
[1] Waibel M, De Angelis M, et al. Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta. Eur J Med Chem. 2009 Sep;44(9):3412-24.
[2] Endo S, Matsunaga T, et al. Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress. Chem Biol Interact. 2009 Mar 16;178(1-3):151-7.
[3] Waibel M, De Angelis M, Stossi F, Kieser KJ, Carlson KE, Katzenellenbogen BS, Katzenellenbogen JA. Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta. Eur J Med Chem. 2009 Sep;44(9):3412-24
[4] Endo S, Matsunaga T, Mamiya H, Hara A, Kitade Y, Tajima K, El-Kabbani O. Characterization of a rat NADPH-dependent aldo-keto reductase (AKR1B13) induced by oxidative stress. Chem Biol Interact. 2009 Mar 16;178(1-3):151-7
[5] Asada Y, Endo S, Inoue Y, Mamiya H, Hara A, Kunishima N, Matsunaga T. Biochemical and structural characterization of a short-chain dehydrogenase/reductase of Thermus thermophilus HB8: a hyperthermostable aldose-1-dehydrogenase with broad substrate specificity. Chem Biol Interact. 2009 Mar 16;178(1-3):117-26
[6] Matsumoto K, Endo S, Ishikura S, Matsunaga T, Tajima K, El-Kabbani O, Hara A. Enzymatic properties of a member (AKR1C20) of the aldo-keto reductase family. Biol Pharm Bull. 2006 Mar;29(3):539-42
[7] Ishikura S, Matsumoto K, Sanai M, Horie K, Matsunaga T, Tajima K, El-Kabbani O, Hara A. Molecular cloning of a novel type of rat cytoplasmic 17beta-hydroxysteroid dehydrogenase distinct from the type 5 isozyme. J Biochem. 2006 Jun;139(6):1053-63
[8] de Oliveira JM, Simões MJ, Mora OA, Simões RS, Oliveira-Filho RM, Oliveira PB, Baracat EC, Soares JM Jr. Effects of hexestrol on mouse ovarian morphology and ovulation. Maturitas. 2008 Jun 20;60(2):153-7
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Hexestrol 实验方案
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1mg
5mg
10mg
1 mM
5 mM
10 mM
3.70mL
0.74mL
0.37mL
18.49mL
3.70mL
1.85mL
36.99mL
7.40mL
3.70mL
Hexestrol 技术信息
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