货号:A228315 同义名: meso-Hexestrol;Bibenzyl
Hexestrol can bind to ERα and ERβ selectively with EC50 of 0.07 nM and 0.175 nM respectively.
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描述 | Hexestrol is a estrogen receptor (ER) subtype-selective ligands. Hexestrol binds to ER α and ER β with EC50 of 0.07 nm and 0.175 nm, respectively[3]. Hexestrol inhibited akr1b13 activity with IC50 of 3.2 μ M[4]. Hexestrol inhibited the activity of D-galactose dehydrogenase in 1-Dehydrogenase of Streptococcus thermophilus with IC50 of 0.063 mm[5]. Hexestrol inhibited the dehydrogenase activity of akr1c20, and the IC50 of 10 μ m 4-androsten-3 α - o1-17-one was 2.7 μ M[6]. Hexestrol inhibited 17hsd5 with IC50 of 30 μ m and tber1 with IC50 of 0.8 μ M[7]. In mice treated with hexestrol (6 mg/kg) (Group II), ovaries were smaller than those from the controls but highly vascularized; similar results were obtained in GIV. The anabolic agent hexestrol in a high dose may decrease ovulation in mice[8]. |
计算器 | ||||
存储液制备 | 1mg | 5mg | 10mg | |
1 mM 5 mM 10 mM |
3.70mL 0.74mL 0.37mL |
18.49mL 3.70mL 1.85mL |
36.99mL 7.40mL 3.70mL |
CAS号 | 84-16-2 |
分子式 | C18H22O2 |
分子量 | 270.366 |
别名 | meso-Hexestrol;Bibenzyl;Sinestrol;HSDB 2149;Erythrohexestrol;Cycloestrol;NSC 9894;Hexoestrol |
运输 | 蓝冰 |
存储条件 |
粉末 Sealed in dry,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
溶解度 |
DMSO: 105 mg/mL(388.36 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO |
动物实验配方 |
IP 2% DMSO+2% Tween80+40% PEG300+water 6 mg/mL clear PO 0.5% CMC-Na 46 mg/mL suspension |