人参皂苷 F1 /Ginsenoside F1 {[allProObj[0].p_purity_real_show]}
货号：A194392同义名：
20(S)-Ginsenoside F1;GF1
Ginsenoside F1, a metabolite of ginsenoside Rg1 isolated and purified from the roots of Panax ginseng C.A.Mey., is reported to be antiaging and antioxidative, and to have beneficial effects on skin.
Ginsenoside F1, a pharmaceutical component of ginseng, is known to have antiaging, antioxidant, anticancer, and keratinocyte protective effects[3]. Ginsenoside F1 (GF1) has been shown to flaunt anticancer, anti-aging, and antioxidant effects and has demonstrated competitive inhibition of CYP3A4 activity and weaker inhibition of CYP2D6 activity. The cell viabilities are 68% at the highest concentration of ginsenoside F1 (200 μM) in MTT assays[4]. ApoE-/- mice were fed a high fat diet and orally treated with GF1 (50 mg/kg/day) for 8 weeks. The treatment with GF1 induced a remarkable reduction in the atherosclerotic lesion area, LOX-1, TLR4 expression and decreased the MPO distribution. GF1 treatment greatly increased ox-LDL-injured endothelial cell viability, ameliorated LOX-1, TLR4 expression levels and reduced monocytes adhesion. Protein microarray demonstrated that GF1 significantly inhibited G-CSF, ICAM-1, MIP-1δ, IL-1α, IL-15, IL-16 levels[5].
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