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首页 / 抑制剂/激动剂 / G蛋白偶联受体/G蛋白 / PAFR / Ginkgolide B

银杏内酯 B /Ginkgolide B {[allProObj[0].p_purity_real_show]}

货号：A188960 同义名： BN-52021;BN 52051

Ginkgolide B, an important active terpenoid from Ginkgo biloba leaves, a PAFR antagonist with IC50 of 3.6 μM, is reported to increase cell viability and decrease cell apoptosis.

Ginkgolide B 化学结构 CAS号：15291-77-7
Ginkgolide B 化学结构
CAS号：15291-77-7
Ginkgolide B 3D分子结构
CAS号：15291-77-7
Ginkgolide B 化学结构 CAS号：15291-77-7
Ginkgolide B 3D分子结构 CAS号：15291-77-7
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Ginkgolide B 纯度/质量文件 产品仅供科研

货号：A188960 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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产品名称 PAFR ↓ 其他靶点 纯度
Ginkgolide B +++

PAFR, IC50: 3.6 μM

 		98%
1. 鼠标悬停在“+”上可以显示相关IC50的具体数值。"+"越多，抑制作用越强。2. "✔"表示该化合物对相应的亚型有抑制作用，但抑制强度暂时没有相关数据。

Ginkgolide B 生物活性

靶点

  • PAFR

    PAFR, IC50:3.6 μM
描述 Ginkgolide B, an important active terpenoid from Ginkgo biloba leaves, is reported to increase cell viability and decrease cell apoptosis. Ginkgolide B exerted anti-inflammatory and chondroprotective effects in LPS(lipopolysaccharide)-induced chondrocytes[3]. Ginkgolide B alleviated the Ox(oxidized)-LDL-induced inflammatory cascades and altered lipid metabolism in HUVECs by suppressing the PCSK-9(proprotein convertase subtilisin/Kexin-9) [4]. Ginkgolide B suppressed platelet and monocyte adhesion under different conditions of laminar shear stress. Moreover, ginkgolide B reduced VCAM-1 (vascular cell adhesion molecule-1), VE-cadherin and Cx43 expression in TNFα-treated HUVECs (human umbilical vein endothelial cells) under laminar shear stress[5]. Oral administration of ginkgolide B (2 mg/kg/day, p.o.) caused a significant increase in cell viability and a highly significant decrease in the numbers of both spontaneously occurring and AAPH-induced apoptoses[6]. In addition, ginkgolide B improves neurological function by promoting the proliferation and differentiation of neural stem cells in rats with cerebral ischemia/reperfusion injury[7].

Ginkgolide B 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03772847 Intravenous Alteplase Thrombol... 展开 >>ysis Neurological Improving 收起 << Phase 4 Recruiting December 1, 2019 China, Zhejiang ... 展开 >> Min Lou Recruiting Hangzhou, Zhejiang, China, 310000 Contact: Zexin Chen    13757118366    HREC2013@126.com 收起 <<
NCT02425436 Intrauterine Growth Restrictio... 展开 >>n (IUGR) 收起 << Phase 2 Completed - -

Ginkgolide B 参考文献

[1]Jean R. Rapin, et al. In vitro and in vivo effects of an extract of Ginkgo biloba (EGb 761), ginkgolide B, and bilobalide on apoptosis in primary cultures of rat hippocampal neurons. Drug Development Research, 1998, 45 (1):1-43

[2]Lamant V, Mauco G, et al. Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. Biochem Pharmacol. 1987 Sep 1;36(17):2749-52.

[3]Hu H, Li Y, Xin Z, Zhanga X. Ginkgolide B exerts anti-inflammatory and chondroprotective activity in LPS-induced chondrocytes. Adv Clin Exp Med. 2018 Jul;27(7):913-920

[4]Wang G, Liu Z, Li M, Li Y, Alvi SS, Ansari IA, Khan MS. Ginkgolide B Mediated Alleviation of Inflammatory Cascades and Altered Lipid Metabolism in HUVECs via Targeting PCSK-9 Expression and Functionality. Biomed Res Int. 2019 Jun 10;2019:7284767

[5]Zhang M, Sun J, Chen B, Zhao Y, Gong H, You Y, Qi R. Ginkgolide B inhibits platelet and monocyte adhesion in TNFα-treated HUVECs under laminar shear stress. BMC Complement Altern Med. 2018 Jul 20;18(1):220

[6]In vitro and in vivo effects of an extract of Ginkgo biloba (EGb 761), ginkgolide B, and bilobalide on apoptosis in primary cultures of rat hippocampal neurons

[7]Zheng PD, Mungur R, Zhou HJ, Hassan M, Jiang SN, Zheng JS. Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury, both in vivo and in vitro. Neural Regen Res. 2018 Jul;13(7):1204-1211

Ginkgolide B 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.78mL

2.36mL

1.18mL

23.56mL

4.71mL

2.36mL

Ginkgolide B 技术信息

CAS号15291-77-7
分子式C20H24O10
分子量 424.399
别名 BN-52021;BN 52051;Bilobalide B
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Store in freezer, under -20°C
溶解度

DMSO: 105 mg/mL(247.41 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Ginkgolide B | BN-52021;BN 52051;Bilobalide B | PAFR | AmBeed-信号通路专用抑制剂 | Ginkgolide B 纯度/质量文件 | Ginkgolide B 亚型比较 | Ginkgolide B 生物活性 | Ginkgolide B 临床数据 | Ginkgolide B 参考文献 | Ginkgolide B 实验方案 | Ginkgolide B 技术信息

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