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Ginkgolide B

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Chemical Structure| 15291-77-7 同义名 : BN-52021;BN 52051;Bilobalide B
CAS号 : 15291-77-7
货号 : A188960
分子式 : C20H24O10
纯度 : 98%
分子量 : 424.399
MDL号 : MFCD05662347
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(247.41 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • PAFR

    PAFR, IC50:3.6 μM
描述 Ginkgolide B, an important active terpenoid from Ginkgo biloba leaves, is reported to increase cell viability and decrease cell apoptosis. Ginkgolide B exerted anti-inflammatory and chondroprotective effects in LPS(lipopolysaccharide)-induced chondrocytes[3]. Ginkgolide B alleviated the Ox(oxidized)-LDL-induced inflammatory cascades and altered lipid metabolism in HUVECs by suppressing the PCSK-9(proprotein convertase subtilisin/Kexin-9) [4]. Ginkgolide B suppressed platelet and monocyte adhesion under different conditions of laminar shear stress. Moreover, ginkgolide B reduced VCAM-1 (vascular cell adhesion molecule-1), VE-cadherin and Cx43 expression in TNFα-treated HUVECs (human umbilical vein endothelial cells) under laminar shear stress[5]. Oral administration of ginkgolide B (2 mg/kg/day, p.o.) caused a significant increase in cell viability and a highly significant decrease in the numbers of both spontaneously occurring and AAPH-induced apoptoses[6]. In addition, ginkgolide B improves neurological function by promoting the proliferation and differentiation of neural stem cells in rats with cerebral ischemia/reperfusion injury[7].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT03772847 Intravenous Alteplase Thrombol... 展开 >>ysis Neurological Improving 收起 << Phase 4 Recruiting December 1, 2019 China, Zhejiang ... 展开 >> Min Lou Recruiting Hangzhou, Zhejiang, China, 310000 Contact: Zexin Chen    13757118366    HREC2013@126.com 收起 <<
NCT02425436 Intrauterine Growth Restrictio... 展开 >>n (IUGR) 收起 << Phase 2 Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.36mL

0.47mL

0.24mL

11.78mL

2.36mL

1.18mL

23.56mL

4.71mL

2.36mL
参考文献

[1]Jean R. Rapin, et al. In vitro and in vivo effects of an extract of Ginkgo biloba (EGb 761), ginkgolide B, and bilobalide on apoptosis in primary cultures of rat hippocampal neurons. Drug Development Research, 1998, 45 (1):1-43

[2]Lamant V, Mauco G, et al. Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. Biochem Pharmacol. 1987 Sep 1;36(17):2749-52.

[3]Hu H, Li Y, Xin Z, Zhanga X. Ginkgolide B exerts anti-inflammatory and chondroprotective activity in LPS-induced chondrocytes. Adv Clin Exp Med. 2018 Jul;27(7):913-920

[4]Wang G, Liu Z, Li M, Li Y, Alvi SS, Ansari IA, Khan MS. Ginkgolide B Mediated Alleviation of Inflammatory Cascades and Altered Lipid Metabolism in HUVECs via Targeting PCSK-9 Expression and Functionality. Biomed Res Int. 2019 Jun 10;2019:7284767

[5]Zhang M, Sun J, Chen B, Zhao Y, Gong H, You Y, Qi R. Ginkgolide B inhibits platelet and monocyte adhesion in TNFα-treated HUVECs under laminar shear stress. BMC Complement Altern Med. 2018 Jul 20;18(1):220

[6]In vitro and in vivo effects of an extract of Ginkgo biloba (EGb 761), ginkgolide B, and bilobalide on apoptosis in primary cultures of rat hippocampal neurons

[7]Zheng PD, Mungur R, Zhou HJ, Hassan M, Jiang SN, Zheng JS. Ginkgolide B promotes the proliferation and differentiation of neural stem cells following cerebral ischemia/reperfusion injury, both in vivo and in vitro. Neural Regen Res. 2018 Jul;13(7):1204-1211