产品说明书
GC376 Sodium Salt
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同义名 : | - |
| CAS号 : | 1416992-39-6 | |
| 货号 : | A723661 | |
| 分子式 : | C21H30N3NaO8S | |
| 纯度 : | 98% | |
| 分子量 : | 507.533 | |
| MDL号 : | MFCD31382192 | |
| 存储条件： |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
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| 描述 | The coronavirus 3C-like protease (3CLpro) has a conserved structure and catalytic mechanism and plays a key role during viral polyprotein processing, thus serving as an appealing antiviral drug target. GC376 exerts strong inhibitory effects on the PEDV (porcine epidemic diarrhea virus) 3CLpro with an IC50 of approximately 1.11 μM. The EC50 values of GC376 against CV777 and YN144 (two PEDV strains) were 11.18 and 14.63 μM, respectively implying that GC376 should efficiently inhibit the replication of different PEDV strains. Compared with the non-drug-treated cells, GC376 reduced virus infection at 1.56 μM. It almost completely inhibited virus replication at approximately 6.25 μM, and cell syncytosis disappeared; 12.5 μM GC376 abolished the infection[1]. | ||
| 作用机制 | GC376 inhibits PEDV replication by blocking the catalytic residues and binding pocket of 3CLpro[1]. | ||
| 实验方案 | |||
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| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.97mL 0.39mL 0.20mL |
9.85mL 1.97mL 0.99mL |
19.70mL 3.94mL 1.97mL |
| 参考文献 |
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