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Evans Blue

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Chemical Structure| 314-13-6 同义名 : Direct Blue 53;C.I. 23860;T-1824
CAS号 : 314-13-6
货号 : A128230
分子式 : C34H24N6Na4O14S4
纯度 : 85% （Dye content）
分子量 : 960.805
MDL号 : MFCD00004021
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(26.02 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO

H2O: 30 mg/mL(31.22 mM)，配合低频超声助溶
动物实验配方：
生物活性
靶点

  • AMPA receptor
描述 Evans Blue (Direct Blue 53) inhibits L-glutamate uptake through the membrane-bound excitatory amino acid transporter (EAAT) and blocks L-glutamate and kainate receptor-mediated currents. It exhibits strong binding to serum albumin, making it a valuable tracer for high molecular weight proteins. Additionally, Evans Blue is applied in studies assessing blood-brain barrier (BBB) permeability[1].[2].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00613886 Normal Pressure Hydrocephalus Not Applicable Terminated(Funding was withdra... 展开 >>wn by Codman as expected number of patient subjects enrolled did not meet expected numbers.) 收起 << - United States, California ... 展开 >> University of California, Irvine - Medical Center Orange, California, United States, 92868 收起 <<
NCT02496013 Arteriovenous Malformation ... 展开 >> Hemangioma Neoplasms Lymph Nodes Lymphedema 收起 << Phase 1 Recruiting December 2017 China, Beijing ... 展开 >> PET centre Recruiting Beijing, Beijing, China, 100730 Contact: Jingjing Zhang, Dr.    +86 15101033017    zhangjingjingtag@163.com    Principal Investigator: Fang Li, Dr. 收起 <<
NCT01058928 - Unknown October 2010 Korea, Republic of ... 展开 >> Seoul National University Bundang Hospital Gyeonggi-do, Korea, Republic of, 463-707 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.04mL

0.21mL

0.10mL

5.20mL

1.04mL

0.52mL

10.41mL

2.08mL

1.04mL
参考文献

[1]Linpeng Yao, et al. Evans Blue Dye: A Revisit of Its Applications in Biomedicine. Contrast Media Mol Imaging. 2018 Apr 22:2018:7628037.

[2]Anatol Manaenko, et al. Comparison Evans Blue injection routes: Intravenous versus intraperitoneal, for measurement of blood-brain barrier in a mice hemorrhage model. J Neurosci Methods. 2011 Feb 15;195(2):206-10.