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/ Estradiol (cypionate)

环戊丙酸雌二醇 /Estradiol (cypionate) {[allProObj[0].p_purity_real_show]}

货号：A394620 同义名： Estradiol 17β-Cyclopentanepropionate;Estradiol Cypionate

Estradiol cypionate is a synthetic ester. Compared to other commonly used estradiol esters, via the intramuscular route, estradiol cypionate is found to have the longest duration of action with a duration of ~11 days,

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There will be a HazMat fee per item when shipping a dangerous goods. The HazMat fee will be charged to your UPS/DHL/FedEx collect account or added to the invoice unless the package is shipped via Ground service. Ship by air in Excepted Quantity (each bottle), which is up to 1g/1mL for class 6.1 packing group I or II, and up to 25g/25ml for all other HazMat items.

Type HazMat fee for 500 gram (Estimated)
Excepted Quantity USD 0.00
Limited Quantity USD 15-60
Inaccessible (Haz class 6.1), Domestic USD 80+
Inaccessible (Haz class 6.1), International USD 150+
Accessible (Haz class 3, 4, 5 or 8), Domestic USD 100+
Accessible (Haz class 3, 4, 5 or 8), International USD 200+
Estradiol (cypionate) 化学结构 CAS号：313-06-4
Estradiol (cypionate) 化学结构
CAS号：313-06-4
Estradiol (cypionate) 3D分子结构
CAS号：313-06-4
Estradiol (cypionate) 化学结构 CAS号：313-06-4
Estradiol (cypionate) 3D分子结构 CAS号：313-06-4
规格 价格 会员价 库存 数量
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Estradiol (cypionate) 纯度/质量文件 产品仅供科研

货号：A394620 标准纯度： {[allProObj[0].p_purity_real_show]}
批次查询： 批次纯度:

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Estradiol (cypionate) 生物活性

描述 Estradiol cypionate (ECP), a long-acting estrogen, has been used therapeutically in early postpartum (PP) dairy cows[3]. Compared with controls and in response to TP (testosterone propionate) or ECP, estrus occurred 8 to 18h earlier and was of greater intensity for ECP cows, respectively[4]. Substituting ECP (Estradiol valerate) for GnRH resulted in more cows in estrus and slightly fewer ovulating[5]. Early postpartum ECP injection increased pregnancy rates, but generally had detrimental effects on milk yields after 30 DIM (d in milk) for ECP-treated cows previously milked 4x daily, unless those cows also were treated with bST (bovine somatotropin)[6]. Use of 1 mg of ECP to induce ovulation as part of a synchrony regimen improved reproduction at first postpartum insemination in dairy cows[7].

Estradiol (cypionate) 临床研究

NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02670785 Vulvovaginal Atrophy ... 展开 >> Menopause Dyspareunia 收起 << Phase 2 Completed - United States, Arizona ... 展开 >> Visions Clinical Research-Tucson Tucson, Arizona, United States, 85712 United States, California Genesis Center for Clinical Research San Diego, California, United States, 92103 United States, Connecticut Coastal Connecticut Research, LLC New London, Connecticut, United States, 06320 United States, Florida Women's Medical Research Group, LLC Clearwater, Florida, United States, 33759 Radiant Research, Inc. Pinellas Park, Florida, United States, 33781 Comprehensive Clinical Trials, LLC West Palm Beach, Florida, United States, 33409 United States, Georgia Fellows Research Alliance, Inc Savannah, Georgia, United States, 31406 United States, Michigan Beyer Research Kalamazoo, Michigan, United States, 49009 United States, Nevada Office of R. Garn Mabey, M.D. Las Vegas, Nevada, United States, 89128 United States, North Carolina Carolina Women's Research and Wellness Center Durham, North Carolina, United States, 27713 Hawthorne Medical Research, Inc. Winston-Salem, North Carolina, United States, 27103 United States, Ohio Rapid Medical Research, Inc. Cleveland, Ohio, United States, 44122 Women's Health Research Columbus, Ohio, United States, 43213 United States, Pennsylvania Clinical Research of Philadelphia, LLC Philadelphia, Pennsylvania, United States, 19114 United States, South Carolina Fellows Research Alliance, Inc Bluffton, South Carolina, United States, 29910 United States, Texas Radiant Research, Inc. Dallas, Texas, United States, 75231 Radiant Research, Inc. San Antonio, Texas, United States, 78229 United States, Virginia Virginia Women's Center Richmond, Virginia, United States, 23233 United States, Washington Seattle Women's Health, Research, Gynecology Seattle, Washington, United States, 98105 North Spokane Women's Clinic Spokane, Washington, United States, 99207 收起 <<
NCT00254189 Ovulation Phase 2 Completed - -
NCT01507454 - Completed - Germany ... 展开 >> Novo Nordisk Investigational Site Mainz, Germany, 55127 收起 <<

Estradiol (cypionate) 参考文献

[1]Overton MW, Sischo WM, et al. Evaluation of effect of estradiol cypionate administered prophylactically to postparturient dairy cows at high risk for metritis. J Am Vet Med Assoc. 2003 Sep 15;223(6):846-51.

[2]Oriowo MA, Landgren BM, et al. A comparison of the pharmacokinetic properties of three estradiol esters. Contraception. 1980 Apr;21(4):415-24.

[3]Haughian JM, Sartori R, Guenther JN, Gümen A, Wiltbank MC. Extending the postpartum anovulatory period in dairy cattle with estradiol cypionate. J Dairy Sci. 2002 Dec;85(12):3238-49

[4]Sauls JA, Voelz BE, Hill SL, Mendonça LGD, Stevenson JS. Increasing estrus expression in the lactating dairy cow. J Dairy Sci. 2017 Jan;100(1):807-820

[5]Stevenson JS, Tiffany SM, Lucy MC. Use of estradiol cypionate as a substitute for GnRH in protocols for synchronizing ovulation in dairy cattle. J Dairy Sci. 2004 Oct;87(10):3298-305

[6]Blevins CA, Shirley JE, Stevenson JS. Milking frequency, estradiol cypionate, and somatotropin influence lactation and reproduction in dairy cows. J Dairy Sci. 2006 Nov;89(11):4176-87

[7]Cerri RL, Santos JE, Juchem SO, Galvão KN, Chebel RC. Timed artificial insemination with estradiol cypionate or insemination at estrus in high-producing dairy cows. J Dairy Sci. 2004 Nov;87(11):3704-15

Estradiol (cypionate) 实验方案

计算器
存储液制备 1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.61mL

2.52mL

1.26mL

25.22mL

5.04mL

2.52mL

Estradiol (cypionate) 技术信息

CAS号313-06-4
分子式C26H36O3
分子量 396.562
别名 Estradiol 17β-Cyclopentanepropionate;Estradiol Cypionate;β-Estradiol 17-cypionate;NSC 3354;Estradiol 17-Cypionate
运输蓝冰
存储条件

液体 -20°C:3-6个月-80°C:12个月

粉末 Sealed in dry,Room Temperature
溶解度

DMSO: 30 mg/mL(75.65 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方

Tags: Estradiol (cypionate) | Estradiol 17β-Cyclopentanepropionate;Estradiol Cypionate;β-Estradiol 17-cypionate;NSC 3354;Estradiol 17-Cypionate | Other Compounds | ERR | AmBeed-信号通路专用抑制剂 | Estradiol (cypionate) 纯度/质量文件 | Estradiol (cypionate) 生物活性 | Estradiol (cypionate) 临床数据 | Estradiol (cypionate) 参考文献 | Estradiol (cypionate) 实验方案 | Estradiol (cypionate) 技术信息

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